Imperial College London
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ProfessorMarcDionne

Faculty of Natural Sciences, Department of Life Sciences

Professor of Innate Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5776m.dionne Website

 
 
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Location

 

G.23Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pean:2017:10.1038/ncomms14642,
author = {Pean, CB and Schiebler, M and Tan, S and Sharrock, J and Kierdorf, K and Brown, K and Maserumule, M and Menezes, S and Platova, M and Bronda, K and Guermonprez, P and Stramer, BM and Floto, R and Dionne, MS},
doi = {10.1038/ncomms14642},
journal = {Nature Communications},
pages = {1--11},
title = {Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection},
url = {http://dx.doi.org/10.1038/ncomms14642},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mycobacterium tuberculosis remains a global threat to human health yet the molecular mechanisms regulating immunity remain poorly understood. Cytokines can promote or inhibit mycobacterial survivalinside macrophages, andthe underlying mechanisms represent potential targets for host-directed therapies. Here we show that cytokine-STAT signaling promotesmycobacterial survivalwithin macrophages by deregulating lipid droplets via ATG2 repression. In Drosophilainfected withMycobacterium marinum,mycobacterium-induced STAT activitytriggered by unpaired-familycytokinesreduces Atg2 expression, permittingderegulation of lipid droplets. Increased Atg2expression, or reduced macrophage triglyceride biosynthesis,normalizes lipid deposition in infected phagocytes and reduces numbersof viable intracellular mycobacteria. In human macrophages,addition ofIL-6promotes mycobacterial survival and BCG-induced lipid accumulation by a similar, but probably not identical, mechanism. Our results reveal Atg2regulation as amechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to mycobacterial infectionin Drosophila.
AU  - Pean,CB
AU  - Schiebler,M
AU  - Tan,S
AU  - Sharrock,J
AU  - Kierdorf,K
AU  - Brown,K
AU  - Maserumule,M
AU  - Menezes,S
AU  - Platova,M
AU  - Bronda,K
AU  - Guermonprez,P
AU  - Stramer,BM
AU  - Floto,R
AU  - Dionne,MS
DO  - 10.1038/ncomms14642
EP  - 11
PY  - 2017///
SN  - 2041-1723
SP  - 1
TI  - Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms14642
UR  - https://www.nature.com/articles/ncomms14642
UR  - http://hdl.handle.net/10044/1/44135
VL  - 8
ER  -
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