Publications
341 results found
Djamgoz MBA, 2020, <i>What Is Life?</i> By Paul Nurse, BIOELECTRICITY, Vol: 2, Pages: 314-315, ISSN: 2576-3105
Djamgoz MBA, Levin M, 2020, Bioelectricity: A Quick Reminder of a Fast-Advancing Discipline!, BIOELECTRICITY, Vol: 2, Pages: 208-209, ISSN: 2576-3105
Schofield Z, Meloni GN, Tran P, et al., 2020, Correction to ‘Bioelectrical understanding and engineering of cell biology’, Journal of the Royal Society Interface, Vol: 17, Pages: 1-1, ISSN: 1742-5662
Schofield Z, Meloni GN, Tran P, et al., 2020, Bioelectrical understanding and engineering of cell biology, Journal of the Royal Society Interface, Vol: 17, Pages: 1-8, ISSN: 1742-5662
The last five decades of molecular and systems biology research have provided unprecedented insights into the molecular and genetic basis of many cellular processes. Despite these insights, however, it is arguable that there is still only limited predictive understanding of cell behaviours. In particular, the basis of heterogeneity in single-cell behaviour and the initiation of many different metabolic, transcriptional or mechanical responses to environmental stimuli remain largely unexplained. To go beyond the status quo, the understanding of cell behaviours emerging from molecular genetics must be complemented with physical and physiological ones, focusing on the intracellular and extracellular conditions within and around cells. Here, we argue that such a combination of genetics, physics and physiology can be grounded on a bioelectrical conceptualization of cells. We motivate the reasoning behind such a proposal and describe examples where a bioelectrical view has been shown to, or can, provide predictive biological understanding. In addition, we discuss how this view opens up novel ways to control cell behaviours by electrical and electrochemical means, setting the stage for the emergence of bioelectrical engineering.
Ribeiro M, Elghajiji A, Fraser SP, et al., 2020, Human breast cancer cells demonstrate electrical excitability, Frontiers in Neuroscience, Vol: 14, Pages: 1-10, ISSN: 1662-453X
Breast cancer is one of the most prevalent types of cancers worldwide and yet, its pathophysiology is poorly understood. Single-cell electrophysiological studies have provided evidence that membrane depolarization is implicated in the proliferation and metastasis of breast cancer. However, metastatic breast cancer cells are highly dynamic microscopic systems with complexities beyond a single-cell level. There is an urgent need for electrophysiological studies and technologies capable of decoding the intercellular signaling pathways and networks that control proliferation and metastasis, particularly at a population level. Hence, we present for the first time non-invasive in vitro electrical recordings of strongly metastatic MDA-MB-231 and weakly/non-metastatic MCF-7 breast cancer cell lines. To accomplish this, we fabricated an ultra-low noise sensor that exploits large-area electrodes, of 2 mm2, which maximizes the double-layer capacitance and concomitant detection sensitivity. We show that the current recorded after adherence of the cells is dominated by the opening of voltage-gated sodium channels (VGSCs), confirmed by application of the highly specific inhibitor, tetrodotoxin (TTX). The electrical activity of MDA-MB-231 cells surpasses that of the MCF-7 cells, suggesting a link between the cells’ bioelectricity and invasiveness. We also recorded an activity pattern with characteristics similar to that of Random Telegraph Signal (RTS) noise. RTS patterns were less frequent than the asynchronous VGSC signals. The RTS noise power spectral density showed a Lorentzian shape, which revealed the presence of a low-frequency signal across MDA-MB-231 cell populations with propagation speeds of the same order as those reported for intercellular Ca2+ waves. Our recording platform paves the way for real-time investigations of the bioelectricity of cancer cells, their ionic/pharmacological properties and relationship to metastatic potential.
Djamgoz MBA, 2020, Hyponatremia and Cancer Progression: Possible Association with Sodium-Transporting Proteins, BIOELECTRICITY, Vol: 2, Pages: 14-20, ISSN: 2576-3105
- Author Web Link
- Cite
- Citations: 3
Djamgoz MBA, Levin M, 2020, Inaugural Issue, BIOELECTRICITY, Vol: 2, Pages: 1-1, ISSN: 2576-3105
Lee A, Fraser SP, Djamgoz MBA, 2019, Propranolol inhibits neonatal Nav1.5 activity and invasiveness of MDA-MB-231 breast cancer cells: Effects of combination with ranolazine, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 234, Pages: 23066-23081, ISSN: 0021-9541
- Author Web Link
- Cite
- Citations: 14
Bugan I, Kucuk S, Karagoz Z, et al., 2019, Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 22, Pages: 569-579, ISSN: 1365-7852
- Author Web Link
- Cite
- Citations: 23
Djamgoz MBA, Fraser SP, Brackenbury WJ, 2019, In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis, CANCERS, Vol: 11
- Author Web Link
- Cite
- Citations: 61
Farooqi AA, de la Roche M, Djamgoz MBA, et al., 2019, Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights, SEMINARS IN CANCER BIOLOGY, Vol: 58, Pages: 65-79, ISSN: 1044-579X
- Author Web Link
- Cite
- Citations: 78
Onkal R, Fraser SP, Djamgoz MBA, 2019, Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-1. Monovalent (H<SUP>+</SUP>) Ions, BIOELECTRICITY, Vol: 1, Pages: 139-147, ISSN: 2576-3105
- Author Web Link
- Cite
- Citations: 6
Djamgoz MBA, Arcangeli A, 2019, Bioelectricity of Cancer, BIOELECTRICITY, Vol: 1, Pages: 113-113, ISSN: 2576-3105
Onkal R, Fraser SP, Djamgoz MBA, 2019, Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-2. Divalent (Cd<SUP>2+</SUP>) and Trivalent (Gd<SUP>3+</SUP>) Ions, BIOELECTRICITY, Vol: 1, Pages: 148-157, ISSN: 2576-3105
- Author Web Link
- Cite
- Citations: 1
Guzel RM, Ogmen K, Ilieva KM, et al., 2019, Colorectal cancer invasiveness in vitro: Predominant contribution of neonatal Nav1.5 under normoxia and hypoxia, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 234, Pages: 6582-6593, ISSN: 0021-9541
- Author Web Link
- Cite
- Citations: 33
Rizaner N, Onkal R, Fraser SP, et al., 2018, Involvement of Intracellular Ca2+Stores in Spontaneous Ca2+Oscillations in a Human Strongly Metastatic Prostate Cancer Cell, Publisher: WILEY, Pages: 52-52, ISSN: 1748-1708
Vysokov NV, Silva J-P, Lelianova VG, et al., 2018, Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones, ELIFE, Vol: 7, ISSN: 2050-084X
- Author Web Link
- Cite
- Citations: 28
Marshall HT, Djamgoz MBA, 2018, Immuno-Oncology: Emerging Targets and Combination Therapies, FRONTIERS IN ONCOLOGY, Vol: 8, ISSN: 2234-943X
- Author Web Link
- Cite
- Citations: 193
Sipahi M, Keles D, Djamgoz MB, et al., 2018, siRNA-directed inhibition of SCN5A increases matrix metalloproteinase-9 expression and activity in MDA-MB-231 metastatic breast cancer cells, Publisher: WILEY, Pages: 334-334, ISSN: 2211-5463
Cort A, Ozben T, Djamgoz MBA, 2018, Oxidative stress and voltage-gated sodium channel activity in human breast cancer cells, Publisher: WILEY, Pages: 359-360, ISSN: 2211-5463
Keles D, Sipahi M, Djamgoz MB, et al., 2018, Tetracaine suppress metastatic cell behaviors through regulating matrix metalloproteinase-2/-9 and TIMP-2 levels in metastatic breast cancer cells, Publisher: WILEY, Pages: 334-334, ISSN: 2211-5463
Pchelintseva E, Djamgoz MBA, 2018, Mesenchymal stem cell differentiation: Control by calcium-activated potassium channels, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 233, Pages: 3755-3768, ISSN: 0021-9541
- Author Web Link
- Cite
- Citations: 38
Lee A, Djamgoz MBA, 2018, Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies, CANCER TREATMENT REVIEWS, Vol: 62, Pages: 110-122, ISSN: 0305-7372
- Author Web Link
- Cite
- Citations: 233
Djamgoz MBA, Akun E, Arslan B, et al., 2017, Cancer in North Cyprus: 1. Current Status, An Overview, CYPRUS JOURNAL OF MEDICAL SCIENCES, Vol: 2, Pages: 9-12, ISSN: 2149-7893
Djamgoz MBA, Akun E, Arslan B, et al., 2017, Cancer in North Cyprus: 2. Biomedical Research Activities, CYPRUS JOURNAL OF MEDICAL SCIENCES, Vol: 2, Pages: 13-18, ISSN: 2149-7893
Yamaci RF, Fraser SP, Battaloglu E, et al., 2017, Neonatal Nav1.5 protein expression in normal adult human tissues and breast cancer, PATHOLOGY RESEARCH AND PRACTICE, Vol: 213, Pages: 900-907, ISSN: 0344-0338
- Author Web Link
- Cite
- Citations: 24
Arslan B, Djamgoz MBA, Akün E, 2016, ARSENIC: A Review on Exposure Pathways, Accumulation, Mobility and Transmission into the Human Food Chain., Rev Environ Contam Toxicol, Vol: 243, Pages: 27-51, ISSN: 0179-5953
This review deals with exposure pathways of arsenic (As), as well as its transfer and uptake processes from its source to the human body. It is proven fact that uptake of inorganic As for a long period can lead to chronic As poisoning and a variety of adverse health effects such as skin, lung and bladder cancer, in addition to cardiovascular diseases, diabetes and gastrointestinal symptoms. As exposure occurs primarily from consumption of potable water containing high amounts of inorganic As and also from consumption of crops cultivated in As contaminated agricultural fields-either naturally or anthropogenically through contaminated air or pesticides-or irrigated with As containing water. In this review, light is shed on the transfer mechanism of As through the food chain and the parameters that enhance mobility of As in the environment. Amounts of As accumulation in plants and the transfer mechanisms are also quite different. These differences in As accumulation, such as in leaves, stems, fruits and roots, are discussed in detail. Moreover, presence of As in some vegetables consumed is given by investigating recent research articles that deal with As concentrations, especially in edible parts. Some comparative data are also presented, concerning the level of concentration of As in rice during washing, cooking and processing stages.
Bonito B, Sauter DRP, Schwab A, et al., 2016, K(Ca)3.1 (IK) modulates pancreatic cancer cell migration, invasion and proliferation: anomalous effects on TRAM-34, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 468, Pages: 1865-1875, ISSN: 0031-6768
Rizaner N, Onkal R, Fraser SP, et al., 2016, Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity., European Biophysics Journal, Vol: 45, Pages: 735-748, ISSN: 0175-7571
The possible association of intracellular Ca(2+) with metastasis in human cancer cells is poorly understood. We have studied Ca(2+) signaling in human prostate and breast cancer cell lines of strongly versus weakly metastatic potential in a comparative approach. Intracellular free Ca(2+) was measured using a membrane-permeant fluorescent Ca(2+)-indicator dye (Fluo-4 AM) and confocal microscopy. Spontaneous Ca(2+) oscillations were observed in a proportion of strongly metastatic human prostate and breast cancer cells (PC-3M and MDA-MB-231, respectively). In contrast, no such oscillations were observed in weakly/non metastatic LNCaP and MCF-7 cells, although a rise in the resting Ca(2+) level could be induced by applying a high-K(+) solution. Various parameters of the oscillations depended on extracellular Ca(2+) and voltage-gated Na(+) channel activity. Treatment with either tetrodotoxin (a general blocker of voltage-gated Na(+) channels) or ranolazine (a blocker of the persistent component of the channel current) suppressed the Ca(2+) oscillations. It is concluded that the functional voltage-gated Na(+) channel expression in strongly metastatic cancer cells makes a significant contribution to generation of oscillatory intracellular Ca(2+) activity. Possible mechanisms and consequences of the Ca(2+) oscillations are discussed.
Batcioglu K, Yildirim B, Satilmis B, et al., 2016, Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model, TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, Vol: 41, Pages: 275-279, ISSN: 0250-4685
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.