Imperial College London
Alternate

Emeritus ProfessorMustafaDjamgoz

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Cancer Biology
 
 
 
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Contact

 

+44 (0)20 7594 5370m.djamgoz

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

341 results found

Krasowska M, Grzywna ZJ, Mycielska ME, Djamgoz MBAet al., 2009, Fractal analysis and ionic dependence of endocytotic membrane activity of human breast cancer cells, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol: 38, Pages: 1115-1125, ISSN: 0175-7571

Journal article

DOUGLAS RH, WAGNER HJ, ZAUNREITER M, BEHRENS UD, DJAMGOZ MBAet al., 2009, THE EFFECT OF DOPAMINE DEPLETION ON LIGHT-EVOKED AND CIRCADIAN RETINOMOTOR MOVEMENTS IN THE TELEOST RETINA, VISUAL NEUROSCIENCE, Vol: 9, Pages: 335-343, ISSN: 0952-5238

Journal article

Chioni A-M, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MBAet al., 2009, A novel adhesion molecule in human breast cancer cells: Voltage-gated Na<SUP>+</SUP> channel β1 subunit, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Vol: 41, Pages: 1216-1227, ISSN: 1357-2725

Journal article

Djamgoz MBA, 2009, FUNCTIONAL EXPRESSION OF ION CHANNELS IN CANCER: A NEW POSSIBILITY IN CLINICAL MANAGEMENT OF OVARIAN CANCER?, IUBMB LIFE, Vol: 61, Pages: 293-293, ISSN: 1521-6543

Journal article

Djamgoz MBA, 2009, VOLTAGE-GATED SODIUM CHANNEL UPREGULATION AS A NOVEL MARKER OF METASTATIC DISEASE: THE CASE FOR HUMAN BREAST CANCER, IUBMB LIFE, Vol: 61, Pages: 298-298, ISSN: 1521-6543

Journal article

Guzel RM, Djamgoz MBA, 2009, EFFECTS OF INSULIN-LIKE GROWTH FACTOR-1 ON METASTATIC CELL BEHAVIORS OF HUMAN METASTATIC BREAST CANCER CELLS, IUBMB LIFE, Vol: 61, Pages: 371-371, ISSN: 1521-6543

Journal article

Mycielska ME, Patel A, Rizaner N, Mazurek MP, Keun H, Patel A, Ganapathy V, Djamgoz MBAet al., 2009, Citrate transport and metabolism in mammalian cells Prostate epithelial cells and prostate cancer, BIOESSAYS, Vol: 31, Pages: 10-20, ISSN: 0265-9247

Journal article

Shao D, Okuse K, Djamgoz MB, 2009, Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression, Int J Biochem Cell Biol, Vol: 41, Pages: 1471-1481, ISSN: 1878-5875

Voltage-gated sodium channels (VGSCs), classically known to play a central role in excitability and signalling in nerves and muscles, have also been found to be expressed in a range of 'non-excitable' cells, including lymphocytes, fibroblasts and endothelia. VGSC abnormalities are associated with various diseases including epilepsy, long-QT syndrome 3, Brugada syndrome, sudden infant death syndrome and, more recently, various human cancers. Given their pivotal role in a wide range of physiological and pathophysiological processes, regulation of functional VGSC expression has been the subject of intense study. An emerging theme is post-translational regulation and macro-molecular complexing by protein-protein interactions and intracellular trafficking, leading to changes in functional VGSC expression in plasma membrane. This partially involves endoplasmic reticulum associated degradation and ubiquitin-proteasome system. Several proteins have been shown to associate with VGSCs. Here, we review the interactions involving VGSCs and the following proteins: p11, ankyrin, syntrophin, beta-subunit of VGSC, papin, ERM and Nedd4 proteins. Protein kinases A and C, as well as Ca(2+)-calmodulin dependent kinase II that have also been shown to regulate intracellular trafficking of VGSCs by changing the balance of externalization vs. internalization, and an effort is made to separate these effects from the short-term phosphorylation of mature proteins in plasma membrane. Two further modulatory mechanisms are reciprocal interactions with the cytoskeleton and, late-stage, activity-dependent regulation. Thus, the review gives an updated account of the range of post-translational molecular mechanisms regulating functional VGSC expression. However, many details of VGSC subtype-specific regulation and pathophysiological aspects remain unknown and these are highlighted throughout for completeness.

Journal article

Borys P, Krasowska M, Grzywna ZJ, Djamgoz MBA, Mycielska MEet al., 2008, Lacunarity as a novel measure of cancer cells behavior, BIOSYSTEMS, Vol: 94, Pages: 276-281, ISSN: 0303-2647

Journal article

Brackenbury WJ, Djamgoz MBA, Isom LL, 2008, An Emerging Role for Voltage-Gated Na<SUP>+</SUP> Channels in Cellular Migration: Regulation of Central Nervous System Development and Potentiation of Invasive Cancers, NEUROSCIENTIST, Vol: 14, Pages: 571-583, ISSN: 1073-8584

Journal article

Diss JKJ, Fraser SP, Walker MM, Patel A, Latchman DS, Djamgoz MBAet al., 2008, β-Subunits of voltage-gated sodium channels in human prostate cancer: quantitative <i>in vitro</i> and <i>in vivo</i> analyses of mRNA expression, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 11, Pages: 325-333, ISSN: 1365-7852

Journal article

Pan H, Djamgoz MBA, 2008, Biochemical constitution of extracellular medium is critical for control of human breast cancer MDA-MB-231 cell motility, JOURNAL OF MEMBRANE BIOLOGY, Vol: 223, Pages: 27-36, ISSN: 0022-2631

Journal article

Palmer CP, Mycielska ME, Burcu H, Osman K, Collins T, Beckerman R, Perrett R, Johnson H, Aydar E, Djamgoz MBAet al., 2008, Single cell adhesion measuring apparatus (SCAMA):: application to cancer cell lines of different metastatic potential and voltage-gated Na<SUP>+</SUP> channel expression, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol: 37, Pages: 359-368, ISSN: 0175-7571

Journal article

Ding Y, Brackenbury WJ, Onganer PU, Montano X, Porter LM, Bates LF, Djamgoz MBAet al., 2008, Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na<SUP>+</SUP> channel activity, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 215, Pages: 77-81, ISSN: 0021-9541

Journal article

Diss JKJ, Calissano M, Gascoyne D, Djamgoz MBA, Latchman DSet al., 2008, Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (<i>SCN9A</i>), MOLECULAR AND CELLULAR NEUROSCIENCE, Vol: 37, Pages: 537-547, ISSN: 1044-7431

Journal article

Kaya H, Bozkurt SU, Erbarut I, Djamgoz MBAet al., 2008, Apocrine carcinomas of the breast in Turkish women: Hormone receptors, c-erbB-2 and p53 immunoexpression, PATHOLOGY RESEARCH AND PRACTICE, Vol: 204, Pages: 367-371, ISSN: 0344-0338

Journal article

Onkal R, Djamgoz MBA, 2008, Electrophysiological and developmental implications of Na plus channel-splice variants, JOURNAL OF NEUROGENETICS, Vol: 22, Pages: 187-190, ISSN: 0167-7063

Journal article

Onkal R, Mattis JH, Fraser SP, Diss JK, Shao D, Okuse K, Djamgoz MBet al., 2008, Alternative splicing of Nav1.5: an electrophysiological comparison of 'neonatal' and 'adult' isoforms and critical involvement of a lysine residue, J Cell Physiol, Vol: 216, Pages: 716-726, ISSN: 1097-4652

In developmentally regulated D1:S3 splicing of Nav1.5, there are 31 nucleotide differences between the 5'-exon ('neonatal') and the 3'-exon ('adult') forms, resulting in 7 amino acid differences in D1:S3-S3/S4 linker. In particular, splicing replaces a conserved negative aspartate residue in the 'adult' with a positive lysine. Here, 'neonatal' and 'adult' Nav1.5 alpha-subunit splice variants were stably transfected into EBNA-293 cells and their electrophysiological properties investigated by whole-cell patch-clamp recording. Compared with the 'adult' isoform, the 'neonatal' channel exhibited (1) a depolarized threshold of activation and voltage at which the current peaked; (2) much slower kinetics of activation and inactivation; (3) 50% greater transient charge (Na(+)) influx; (4) a stronger voltage dependence of time to peak; and (5) a slower recovery from inactivation. Tetrodotoxin sensitivity and VGSCbeta1-4 mRNA expression levels did not change. The significance of the charge-reversing aspartate to lysine substitution was investigated by mutating the lysine in the 'neonatal' channel back to aspartate. In this 'neonatal K211D' mutant, the electrophysiological parameters studied strongly shifted back towards the 'adult', that is the lysine residue was primarily responsible for the electrophysiological effects of Nav1.5 D1:S3 splicing. Taken together, these data suggest that the charge reversal in 'neonatal' Nav1.5 would (1) modify the channel kinetics and (2) prolong the resultant current, allowing greater intracellular Na(+) influx. Developmental and pathophysiological consequences of such differences are discussed.

Journal article

Hincal E, Taneri B, Taneri U, Djamgoz MBAet al., 2008, Cancer Incidence in North Cyprus (1990-2004) Relative to European Rates, ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol: 9, Pages: 725-732, ISSN: 1513-7368

Journal article

Palmer CP, Mahen R, Schnell E, Djamgoz MBA, Aydar Eet al., 2007, Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines, CANCER RESEARCH, Vol: 67, Pages: 11166-11175, ISSN: 0008-5472

Journal article

Uysal-Onganer P, Djamgoz MB, 2007, Epidermal growth factor potentiates in vitro metastatic behaviour of human prostate cancer PC-3M cells: involvement of voltage-gated sodium channel, MOLECULAR CANCER, Vol: 6

Journal article

Brackenbury WJ, Djamgoz MBA, 2007, Nerve growth factor enhances voltage-gated Na<SUP>+</SUP> channel activity and transwell migration in Mat-LyLu rat prostate cancer cell line, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 210, Pages: 602-608, ISSN: 0021-9541

Journal article

Chong A, Zhang Z, Choi KP, Choudhary V, Djamgoz MBA, Zhang G, Bajic VBet al., 2007, Promoter profiling and coexpression data analysis identifies 24 novel genes that are coregulated with AMPA receptor genes, GRIAs, GENOMICS, Vol: 89, Pages: 378-384, ISSN: 0888-7543

Journal article

Brackenbury WJ, Chioni A-M, Diss JKJ, Djamgoz MBAet al., 2007, The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells, BREAST CANCER RESEARCH AND TREATMENT, Vol: 101, Pages: 149-160, ISSN: 0167-6806

Journal article

Scorey N, Fraser SP, Patel P, Pridgeon C, Dallman MJ, Djamgoz MBAet al., 2006, Notch signalling and voltage-gated Na<SUP>+</SUP> channel activity in human prostate cancer cells:: independent modulation of <i>in vitro</i> motility, PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 9, Pages: 399-406, ISSN: 1365-7852

Journal article

Aydar E, Onganer P, Perrett R, Djamgoz MB, Palmer CPet al., 2006, The expression and functional characterization of sigma (σ) 1 receptors in breast cancer cell lines, CANCER LETTERS, Vol: 242, Pages: 245-257, ISSN: 0304-3835

Journal article

Brackenbury WJ, Djamgoz MBA, 2006, Activity-de pendent regulation of voltage-gated Na<SUP>+</SUP> channel expression in Mat-LyLu rat prostate cancer cell line, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 573, Pages: 343-356, ISSN: 0022-3751

Journal article

Ozerlat I, Djamgoz MBA, 2006, Oestrogen signalling and human breast cancer: potential role of voltage-gated sodium channels, 31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), Publisher: BLACKWELL PUBLISHING, Pages: 106-106, ISSN: 1742-464X

Conference paper

Yamaci RF, Kaya H, Djamgoz MBA, Battaloglu Eet al., 2006, Role of voltage-gated sodium channels in breast cancer metastasis and the effect of oestrogen on VGSC function, 31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), Publisher: WILEY, Pages: 107-107, ISSN: 1742-464X

Conference paper

Isbilen B, Fraser SP, Djamgoz MBA, 2006, Omega-3 fatty acid and breast cancer: possible involvement of voltage-gated sodium channel, 31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), Publisher: BLACKWELL PUBLISHING, Pages: 300-300, ISSN: 1742-464X

Conference paper

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