Imperial College London
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DrMargaritaDominguez-Villar

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3735m.dominguez-villar Website

 
 
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Location

 

117Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gautron:2014:10.1002/eji.201344392,
author = {Gautron, A-S and Dominguez-Villar, M and de, Marcken M and Hafler, DA},
doi = {10.1002/eji.201344392},
journal = {European Journal of Immunology},
pages = {2703--2711},
title = {Enhanced suppressor function of TIM-3(+)FoxP3(+) regulatory T cells},
url = {http://dx.doi.org/10.1002/eji.201344392},
volume = {44},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tcell immunoglobulin and mucin domain 3 (TIM3) is an Igsuperfamily member expressed on IFNγsecreting Th1 and Tc1 cells and was identified as a negative regulator of immune tolerance. TIM3 is expressed by a subset of activated CD4+ T cells, and antiCD3/antiCD28 stimulation increases both the level of expression and the number of TIM3+ T cells. In mice, TIM3 is constitutively expressed on natural regulatory T (Treg) cells and has been identified as a regulatory molecule of alloimmunity through its ability to modulate CD4+ Tcell differentiation. Here, we examined TIM3 expression on human Treg cells to determine its role in Tcell suppression. In contrast to mice, TIM3 is not expressed on Treg cells ex vivo but is upregulated after activation. While TIM3+ Treg cells with increased gene expression of LAG3, CTLA4, and FOXP3 are highly efficient suppressors of effector T (Teff) cells, TIM3− Treg cells poorly suppressed Th17 cells as compared with their suppression of Th1 cells; this decreased suppression ability was associated with decreased STAT3 expression and phosphorylation and reduced gene expression of IL10, EBI3, GZMB, PRF1, IL1Rα, and CCR6. Thus, our results suggest that TIM3 expression on Treg cells identifies a population highly effective in inhibiting pathogenic Th1 and Th17cell responses.
AU  - Gautron,A-S
AU  - Dominguez-Villar,M
AU  - de,Marcken M
AU  - Hafler,DA
DO  - 10.1002/eji.201344392
EP  - 2711
PY  - 2014///
SN  - 0014-2980
SP  - 2703
TI  - Enhanced suppressor function of TIM-3(+)FoxP3(+) regulatory T cells
T2  - European Journal of Immunology
UR  - http://dx.doi.org/10.1002/eji.201344392
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342818900018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201344392
VL  - 44
ER  -
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