Imperial College London
Portrait Picture

DrMargaritaDominguez-Villar

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 3735m.dominguez-villar Website

 
 
//

Location

 

117Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dominguez-Villar:2019:10.1016/j.jaut.2018.08.002,
author = {Dominguez-Villar, M and Raddassi, K and Danielsen, AC and Guarnaccia, J and Hafler, DA},
doi = {10.1016/j.jaut.2018.08.002},
journal = {Journal of Autoimmunity},
pages = {40--49},
title = {Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo},
url = {http://dx.doi.org/10.1016/j.jaut.2018.08.002},
volume = {96},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fingolimod is an approved therapeutic option for patients with relapsing-remitting multiple sclerosis that primarily functions by sequestering T cells in lymph nodes inhibiting their egress to the central nervous system. However, recent data suggests that Fingolimod may also directly affect the immune cell function. Here we examined the in vivo effects of Fingolimod in modulating the phenotype and function of T cell and Foxp3 regulatory T cell populations in patients with multiple sclerosis under Fingolimod treatment. Besides decreasing the cell numbers in peripheral blood and sera levels of pro-inflammatory cytokines, Fingolimod inhibited the expression of Th1 and Th17 cytokines on CD4+ T cells and increased the expression of exhaustion markers. Furthermore, treatment increased the frequency of regulatory T cells in blood and inhibited the Th1-like phenotype that is characteristic of patients with multiple sclerosis, augmenting the expression of markers associated with increased suppressive function. Overall, our data suggest that Fingolimod performs other important immunomodulatory functions besides altering T cell migratory capacities, with consequences for other autoimmune pathologies characterized by excessive Th1/Th17 responses and Th1-like regulatory T cell effector phenotypes.
AU  - Dominguez-Villar,M
AU  - Raddassi,K
AU  - Danielsen,AC
AU  - Guarnaccia,J
AU  - Hafler,DA
DO  - 10.1016/j.jaut.2018.08.002
EP  - 49
PY  - 2019///
SN  - 0896-8411
SP  - 40
TI  - Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo
T2  - Journal of Autoimmunity
UR  - http://dx.doi.org/10.1016/j.jaut.2018.08.002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30122421
UR  - http://hdl.handle.net/10044/1/64176
VL  - 96
ER  -
Download