Imperial College London
Portrait Picture

Professor Marc-Emmanuel Dumas

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Systems Medicine
 
 
 
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Contact

 

+44 (0)20 7594 1820m.dumas Website

 
 
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Assistant

 

Mrs Patricia Murphy +44 (0)20 7594 1603

 
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Location

 

E315BBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brial:2020:10.1016/j.celrep.2020.01.066,
author = {Brial, F and Alzaid, F and Sonomura, K and Kamatani, Y and Meneyrol, K and Le, Lay A and Pean, N and Hedjazi, L and Sato, T-A and Venteclef, N and Magnan, C and Lathrop, M and Dumas, M-E and Matsuda, F and Zalloua, P and Gauguier, D},
doi = {10.1016/j.celrep.2020.01.066},
journal = {Cell Reports},
pages = {2306--2320},
title = {The natural metabolite 4-cresol improves glucose homeostasis and enhances beta-cell function},
url = {http://dx.doi.org/10.1016/j.celrep.2020.01.066},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs). Through metabolome profiling, we identify the inverse correlation between serum concentrations of 4-cresol and type 2 diabetes. The chronic administration of non-toxic doses of 4-cresol in complementary preclinical models of CMD reduces adiposity, glucose intolerance, and liver triglycerides, enhances insulin secretion in vivo, stimulates islet density and size, and pancreatic β-cell proliferation, and increases vascularization, suggesting activated islet enlargement. In vivo insulin sensitivity is not affected by 4-cresol. The incubation of mouse isolated islets with 4-cresol results in enhanced insulin secretion, insulin content, and β-cell proliferation of a magnitude similar to that induced by GLP-1. In both CMD models and isolated islets, 4-cresol is associated with the downregulated expression of the kinase DYRK1A, which may mediate its biological effects. Our findings identify 4-cresol as an effective regulator of β-cell function, which opens up perspectives for therapeutic applications in syndromes of insulin deficiency.
AU  - Brial,F
AU  - Alzaid,F
AU  - Sonomura,K
AU  - Kamatani,Y
AU  - Meneyrol,K
AU  - Le,Lay A
AU  - Pean,N
AU  - Hedjazi,L
AU  - Sato,T-A
AU  - Venteclef,N
AU  - Magnan,C
AU  - Lathrop,M
AU  - Dumas,M-E
AU  - Matsuda,F
AU  - Zalloua,P
AU  - Gauguier,D
DO  - 10.1016/j.celrep.2020.01.066
EP  - 2320
PY  - 2020///
SN  - 2211-1247
SP  - 2306
TI  - The natural metabolite 4-cresol improves glucose homeostasis and enhances beta-cell function
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2020.01.066
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000514824500022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2211124720300917?via%3Dihub
UR  - http://hdl.handle.net/10044/1/79053
VL  - 30
ER  -
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