Imperial College London
Portrait Picture

Professor Marc-Emmanuel Dumas

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Systems Medicine
 
 
 
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Contact

 

+44 (0)20 7594 1820m.dumas Website

 
 
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Assistant

 

Mrs Patricia Murphy +44 (0)20 7594 1603

 
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Location

 

E315BBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brial:2018:10.1101/444893,
author = {Brial, F and Alzaid, F and Sonomura, K and Meneyrol, K and Le, Lay A and Péan, N and Neves, A and Chilloux, J and Hedjazi, L and Sato, T-A and Martinez, AR and Venteclef, N and Nicholson, JK and Magnan, C and Lathrop, M and Dumas, M-E and Matsuda, F and Zalloua, P and Gauguier, D},
doi = {10.1101/444893},
title = {The Microbial Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function},
url = {http://dx.doi.org/10.1101/444893},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>SUMMARY</jats:title><jats:p>Gut microbiota changes are associated with increased risk of Type 2 diabetes (T2D) and obesity. Through serum metabolome profiling in patients with cardiometabolic disease (CMD) we identified significant inverse correlation between the microbial metabolite 4-cresol and T2D. Chronic administration of non toxic dose of 4-cresol in two complementary preclinical models of CMD reduced adiposity, glucose intolerance and liver triglycerides, and enhanced insulin secretion <jats:italic>in vivo</jats:italic>, which may be explained by markedly increased pancreas weight, augmented islet density and size, and enhanced vascularisation suggesting activated islet neogenesis. Incubation of isolated islets with 4-cresol enhanced insulin secretion, insulin content and cell proliferation. In both CMD models 4-cresol treatment <jats:italic>in vivo</jats:italic> was associated with altered expression of SIRT1 and the kinase DYRK1A, which may contribute to mediate its biological effects. Our findings identify 4-cresol as an effective regulator of β-cell function and T2D endophenotypes, which opens therapeutic perspectives in syndromes of insulin deficiency.</jats:p>
AU  - Brial,F
AU  - Alzaid,F
AU  - Sonomura,K
AU  - Meneyrol,K
AU  - Le,Lay A
AU  - Péan,N
AU  - Neves,A
AU  - Chilloux,J
AU  - Hedjazi,L
AU  - Sato,T-A
AU  - Martinez,AR
AU  - Venteclef,N
AU  - Nicholson,JK
AU  - Magnan,C
AU  - Lathrop,M
AU  - Dumas,M-E
AU  - Matsuda,F
AU  - Zalloua,P
AU  - Gauguier,D
DO  - 10.1101/444893
PY  - 2018///
TI  - The Microbial Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function
UR  - http://dx.doi.org/10.1101/444893
ER  -
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