Imperial College London
Portrait Picture

Professor Marc-Emmanuel Dumas

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Systems Medicine
 
 
 
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Contact

 

+44 (0)20 7594 1820m.dumas Website

 
 
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Assistant

 

Mrs Patricia Murphy +44 (0)20 7594 1603

 
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Location

 

E315BBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nuzzo:2021:10.1038/s41598-021-98012-w,
author = {Nuzzo, A and Guedj, K and Curac, S and Hercend, C and Bendavid, C and Gault, N and Tran-Dinh, A and Ronot, M and Nicoletti, A and Bouhnik, Y and Castier, Y and Corcos, O and Peoc'h, K},
doi = {10.1038/s41598-021-98012-w},
journal = {Scientific Reports},
pages = {1--10},
title = {Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia},
url = {http://dx.doi.org/10.1038/s41598-021-98012-w},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.
AU  - Nuzzo,A
AU  - Guedj,K
AU  - Curac,S
AU  - Hercend,C
AU  - Bendavid,C
AU  - Gault,N
AU  - Tran-Dinh,A
AU  - Ronot,M
AU  - Nicoletti,A
AU  - Bouhnik,Y
AU  - Castier,Y
AU  - Corcos,O
AU  - Peoc'h,K
DO  - 10.1038/s41598-021-98012-w
EP  - 10
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-98012-w
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000698791600100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41598-021-98012-w
UR  - http://hdl.handle.net/10044/1/93262
VL  - 11
ER  -
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