Imperial College London

DrMarinaEdelson-Averbukh

Faculty of Natural SciencesDepartment of Physics

Research Fellow in Mass Spectrometry
 
 
 
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Contact

 

m.edelson-averbukh

 
 
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Location

 

209Blackett LaboratorySouth Kensington Campus

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Summary

 

Summary

I am a mass spectrometrist, working on the development of new methods for biomolecular structure determination. I have been leading a collaboration between Physics, Chemistry and Surgery & Cancer at Imperial to develop a new kind of two-dimensional mass spectrometry based on the physical principle of partial covariance mapping. The fragment ion correlations revealed by our partial covariance two-dimensional mass spectrometry (pC-2DMS) provide highly specific information on the biomolecular building block sequence, much more so than the individual fragment mass-to-charge ratios on which the 1D MS is based. As a result, pC-2DMS can solve structural problems inaccessible to the standard 1D technique. 

Here is an example of pC-2DMS spectrum of a triply charged peptide ion:

pC-2DMS

See more in our recent preprint: arXiv:1904.05946. The pC2DMS technology is subject to two patent applications developed in collaboration with Imperial Innovations.  

Within the Laser Consortium of the Blackett Laboratory, I work on application of ultrashort laser pulses to biomolecular mass spectrometry, as well as on the development of  coherent control schemes for the optimal protein sequence coverage. 

I obtained my PhD in organic mass spectrometry from Technion - Israel Institute of Technology, after which I moved to the German Cancer Research Centre (DKFZ, Heidelberg) as a Minerva (Max Planck Society) postdoctoral fellow. In DKFZ, I developed negative ion mode collision-induced dissociation for protein post-translational modifications, the field I continued to advance as a German Research Foundation Principal Investigator (DFG Eigene Stelle) in the Max Planck Institute of Molecular Cell Biology and Genetics. After filling a number of university teaching lecturer positions in the UK, I was awarded Wellcome Trust Research Fellowship to create the pC-2DMS.

Publications

Journals

Katsanovskaja K, Driver T, Pipkorn R, et al., 2019, Negative Ion Mode Collision-Induced Dissociation for Analysis of Protein Arginine Methylation, Journal of the American Society for Mass Spectrometry, Vol:30, ISSN:1044-0305, Pages:1229-1241

Tittebrandt S, Edelson-Averbukh M, Spengler B, et al., 2013, ESI Hydrogen/Deuterium Exchange Can Count Chemical Forms of Heteroatom-Bound Hydrogen, Angewandte Chemie-international Edition, Vol:52, ISSN:1433-7851, Pages:8973-8975

Edelson-Averbukh M, Shevchenko A, Pipkorn R, et al., 2011, Discrimination Between Peptide O-Sulfo- and O-Phosphotyrosine Residues by Negative Ion Mode Electrospray Tandem Mass Spectrometry, Journal of the American Society for Mass Spectrometry, Vol:22, ISSN:1044-0305, Pages:2256-2268

Edelson-Averbukh M, Shevchenko A, Pipkorn R, et al., 2009, Gas-Phase Intramolecular Phosphate Shift in Phosphotyrosine-Containing Peptide Monoanions, Analytical Chemistry, Vol:81, ISSN:0003-2700, Pages:4369-4381

Edelson-Averbukh M, Pipkorn R, Lehmann WD, 2007, Analysis of protein phosphorylation in the regions of consecutive serine/threonine residues by negative ion electrospray collision-induced dissociation. Approach to pinpointing of phosphorylation sites, Analytical Chemistry, Vol:79, ISSN:0003-2700, Pages:3476-3486

More Publications