Imperial College London

DrMarinaEdelson-Averbukh

Faculty of Natural SciencesDepartment of Physics

Research Fellow in Mass Spectrometry
 
 
 
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Contact

 

m.edelson-averbukh

 
 
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Location

 

209Blackett LaboratorySouth Kensington Campus

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Summary

 

Summary

I am a mass spectrometrist, working on the development of new methods for biomolecular structure determination. I have been leading a collaboration between Physics, Chemistry and Surgery & Cancer at Imperial to develop a new kind of two-dimensional mass spectrometry based on the physical principle of partial covariance mapping. The fragment ion correlations revealed by our two-dimensional partial covariance mass spectrometry (2D-PC-MS) provide highly specific information on the biomolecular building block sequence, much more so than the individual fragment mass-to-charge ratios on which the 1D MS is based. As a result, 2D-PC-MS can solve structural problems inaccessible to the standard 1D technique. 

Here is an example of 2D-PC-MS spectrum of a triply charged peptide ion:

pC-2DMS

See more in our recent paper which received coverage in Physics Today. The 2D-PC-MS technology is subject to two patent applications highlighted by the Enterprise Division of Imperial.

Within the Extreme Light Consortium of the Blackett Laboratory, I work on application of ultrashort laser pulses to biomolecular mass spectrometry, as well as on the development of coherent control schemes for the optimal protein sequence coverage. 

I obtained my PhD in organic mass spectrometry from Technion - Israel Institute of Technology, after which I moved to the German Cancer Research Centre (DKFZ, Heidelberg) as a Minerva (Max Planck Society) postdoctoral fellow. In DKFZ, I developed negative ion mode collision-induced dissociation for protein post-translational modifications, the field I continued to advance as a German Research Foundation Principal Investigator (DFG Eigene Stelle) in the Max Planck Institute of Molecular Cell Biology and Genetics. After filling a number of university teaching lecturer positions in the UK, I was awarded Wellcome Trust Research Fellowship to create the 2D-PC-MS.

Publications

Journals

Driver T, Averbukh V, Frasiński LJ, et al., 2021, Two-dimensional partial covariance mass spectrometry for the top-down analysis of intact proteins., Analytical Chemistry, Vol:93, ISSN:0003-2700, Pages:10779-10788

Driver T, Bachhawat N, Frasinski L, et al., 2021, Chimera spectrum diagnostics for peptides using two-dimensional partial covariance mass spectrometry, Molecules, Vol:26, ISSN:1420-3049

Driver T, Cooper B, Ayers R, et al., 2020, Two-dimensional partial covariance mass spectrometry of large molecules based on fragment correlations, Physical Review X, Vol:10, ISSN:2160-3308, Pages:041004 – 1-041004 – 13

Katsanovskaja K, Driver T, Pipkorn R, et al., 2019, Negative ion mode collision-induced dissociation for analysis of protein arginine methylation, Journal of the American Society for Mass Spectrometry, Vol:30, ISSN:1044-0305, Pages:1229-1241

Tittebrandt S, Edelson-Averbukh M, Spengler B, et al., 2013, ESI Hydrogen/Deuterium Exchange Can Count Chemical Forms of Heteroatom-Bound Hydrogen, Angewandte Chemie-international Edition, Vol:52, ISSN:1433-7851, Pages:8973-8975

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