Research Focus
My current research projects are mainly in the field of gynaecological pathology, with particular interest in borderline ovarian tumours (BOTs). Over the past 5 years I have set up an integrated research plan to study borderline ovarian tumours, an understudied but significant type of ovarian tumours. The plan included, a national survey of the current management of BOTs in the UK, setting up a national multicentre study, and laboratory studies of the molecular pathology of BOTs. This work provides a unique integrated and in depth investigation of BOTs. Results to date are now presented in 4 publications. A paper recently published in the American Journal of Pathology, one of the top journals in the field of Pathology, represents the first report of the presence of molecular subtypes of BOTs identified by gene methylation profiling, a concept further confirmed by genome wide gene expression profiling (manuscript in press in Modern Pathology). These findings have the potential of influencing changes in the current classification of BOTs with implications on diagnosis and treatment protocols.
In addition to original research papers I published several case reports, some of which presented the first report of a new histological variant of a rare tumour (e.g. El-Bahrawy et al Pancreas 2010), a new histological feature (e.g. Bagwan et al Histopathology 2008), new gene mutation in a rare syndrome (e.g. Barker et al Int J Gynecol Pathol. 2010). Some of these reports were the initiators of international collaborations with groups interested in these rare and unusual entities.
I am collaborating with several research teams within Imperial College London and in other national and international institutions.
Collaborators
Professor Glenn McCluggage, Queen’s University of Belfast, Northern Ireland., 2012
Medical Education, Training and Research., Medical Services of the Egyptian Armed Forces
Dr Pradeep Tanwar, University of Newcastle, NSW, Australia
Prof. Ian Tomlinson, University of Oxford
Prof. David Bowtell, Peter MacCallum Cancer Centre
Dr Blaise Clarke, Toronto General Hospital
Prof. Andrew Silver, Queen Mary, University of London
Guest Lectures
The role of genomics in the management of ovarian Cancer, Annual Egyptian Oncology Summit, Luxor, Egypt, 2022
Lower female genital tract cases, The British Association of Gynaecological Pathologists, United Kingdom, 2022
Ovarian sex cord stromal tumours, London Deanery Trainee Teaching day, United Kingdom, 2022
Update on the genomics of uterine tumours, Africa Health ExCon, Cairo, Egypt, 2022
Update on the genomics of ovarian tumours, Africa Health ExCon, Cairo, Egypt, 2022
A United Kingdom Perspective in Medical Education and Training, Faculty of Medicine, Modern Technology and Information University, Cairo, Egypt, 2021
The role of the pathologist in early detection of cancer, Annual Egyptian Oncology Summit, Luxor, Egypt, 2021
The role of NGOs in medical education and training, Annual Egyptian Oncology Summit, Luxor, Egypt, 2021
Recent advances in Diagnostic Pathology; Digital Pathology and Artificial Intelligence, Annual International Egyptian Oncology Summit, Luxor, Egypt, 2019
Update on the molecular pathology of endometrial carcinoma, Annual Conference of the National Cancer Institute, Cairo, Egypt, 2019
Recent advances in Histopathology laboratories, International Egyptian Oncology Summit, Luxor, Egypt, 2018
Molecular pathology of endometrial cancer, The Annual Conference of the Egyptian Society of Pathology, Cairo, Egypt, 2018
Reflections on vulvovaginal lesions, The Annual Conference of the Egyptian Society of Pathology, Cairo, Egypt, 2018
The principles of classification, grading and staging of tumours, The Annual Conference of the National Cancer Institute, Cairo, Egypt, 2018
The role of the Histopathologist in Multidisciplinary cancer patient care, The Annual Conference of the National Cancer Institute, Cairo Egypt, 2018
Molecular advances in Gynaecological Tumours, Association of Clinical Pathologists, London, United Kingdom, 2018
Unusual changes in dermoids., The British Association of Gynaecological Pathologists., United Kingdom, 2018
- Undifferentiated and miscellaneous tumours of the ovary- Minimum datasets for reporting of endometrial carcinoma- Case presentations, Alexandria Faculty of Medicine, Egypt, 2017
The interesting aspects in the histopathological diagnosis of cervical cancer., Masterclass in Gynaecological Oncology, Imperial College London,, 2017
Endometrial stromal tumoursOvarian serous tumoursSlide seminar, Egyptian Society of Pathology / Egyptian Committee for Pathology Training ,, Egypt., 2017
How to make a diagnosis, International Pathology Summer School of The RCPath, United Kingdom, 2017
What is new in gynaecological pathology since May 2017, British Association of Gynaecological Pathologists, United Kingdom, 2017
The Multidisciplinary; The case in management of breast cancer, Alexandria Faculty of Medicine, Egypt, 2017
Molecular Oncology: Towards a strategy of developing optimal service., Immigrant Egyptian Oncology Forum, Egypt, 2018
- The multidisciplinary team- The role of the pathologist in hereditary cancer syndromes, SpecializedUniversal Network of Oncology, Egypt, 2016
- Reflections on mucinous carcinoma: The breast and the large bowel- Challenges from the Appendix, Specialised Universal Network of Oncology, Egypt, 2015
Pathology of borderline ovarian tumours, London Cancer Alliance, United Kingdom, 2015
Implementing a new Egyptian model for training, supervision and assessment., Postgraduate Specialty Training, Assessment and Examinations inPathology & Laboratory Medicine - The Egyptian Committee for Pathology Training / The Royal College of Pathologists, Cairo, Egypt, 2015
Cancer datasets, Histopathology Trainee Development Day of The Egyptian Committee for Pathology Training / The Royal College of Pathologists, Cairo, Egypt, 2015
Tissue Pathways, Histopathology Trainee Development Day - The Egyptian Committee for Pathology Training / The Royal College of Pathologists., Cairo, Egypt, 2015
1- Pathological diagnosis of endometrial Carcinoma2- Recent advances in epithelial ovarian tumours3- Update on borderline ovarian tumours4- Meet the expert - Gynaecologica Pathology slide seminar, 7th International Conference of The Royal Medical Services and 4th ICMM Pan Arab Regional Working Group Congress on Military Medicine, Jordan, 2014
Pathology of renal malignancies, Urological malignancies conference, Alexandria, Egypt, 2013
Pathology of prostate cancer, Urological malignancies conference, Alexandria, Egypt, 2013
Developments in cancer genetics for gynaecologists., The Royal College of Obstetricians and Gynaecologists, London, 2012
Slide seminar on Urologic Pathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt, 2011
Workshop on uterine pathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt, 2010
The pathology and diagnosis of borderline ovarian tumours., University College London, London, 2009
Gynaecological Pathology and Cytology, Alexandria Regional Centre for Women's Health and Development, Alexandria, Egypt, 2008
Recent advances in Diagnostic Pathology; Digital Pathology and Artificial Intelligence, Annual International Egyptian Oncolgoy Summit, Luxor, Egypt
Update on the molecular pathology of endometrial carcinoma, Annual Conference of the National Cancer Institute, Cairo, Egypt
Research Staff
Masood,M
Research Student Supervision
Aboelnasr,L, Identification of prognostic biomarkers and therapeutic targets in ovarian cancer.
Al-Rabeh,R, The impact of the tumour suppressor OPCML on RTK signalling in breast cancer, its likely downregulation of HER2 and EphA2 and consequent therapeutic potential.
Alacoque,B, The role of interleukin-8 and interleukin-8 receptors expression in platinum resistance in ovarian cancer
Ayappi,R, Exploring the role of Interleukin-8 in conferring resistance to Cisplatin in Ovarian Cancer
Balasubramaniam,E, Expression of cytokines and cytokine receptors in fallopian tubes with tubal ectopic gestation
Binkhamis,R, Expression of Claudin 3 in fallopian tubes with ectopic gestation
Chen,K, Characterisation of in vitro models of granulosa cell tumours
Clarke,A, - Expression of P-cadherin and N-cadherin in ovarian sex cord stromal tumours.
Ewington,L, The expression of interleukin 8 receptors in endometrial carcinoma
Goharji,S, Expression of Prolactin and Prolactin receptor in endometrial carcinoma.
Hedley,C, WT-1 in endometrial serous carcinoma
Hollingshed,J, The expression of EGFR, HER-2 and downstream targets in adenomas and carcinomas of familial adenomatous polyposis patients
Jeyapalan,S, The role of IL-8 in platinum resistance in ovarian cancer.
Khoo,I, Assessment of interstitial cells of Cajal in fallopian tubes with ectopic gestation.
Kyriakides,M, Metabonomic Analysis of Ovarian Cyst Fluid
Magdy,N, The role of prolactin receptor in ovarian carcinoma
Mascaro,N, Determining the histogenesis of a newly described tumour entity
Masood,M, Studying the function and regulation of anticancer genes
Mitchell,H, - Modulators of E-cadherin in endometrial carcinogenesis
Mohamed,R, The role of prolactin receptor in ovarian carcinoma
Nirada,O, Optimisation of in vitro growth conditions for low grade ovarian serous carcinoma cells
Olusoji,M, Expression of Mel-cam and HSD3B1 in cervical carcinoma.
Pataia,V, Expression of VEGFF-2 in fallopian tubes with ectopic gestation
Philips,A, - Biochemical characterisation and localisation of the E-cadherin-catenin complex in a panel of colorectal carcinoma cell lines
Qize,D, Identification of anticancer genes
Qureshi,Y, The expression and colocalisation of trefoils and mucins in various pancreatic pathologies
Sadler,Y, - Expression of Interleukin-8 and Il-8 receptors, CXCR-1 and CXCR-2 in colorectal carcinoma
Salam,T, Borderline Ovarian Tumours; A thorough investigation towards developing a strategy for optimal care
Sharif,A, The role of IL-8 and STATs in platinum resistance in ovarian caner
Slesser,A, The expression of WWOX in pancreatic adenocarcinoma
Southern,A, Comparative molecular profiling of primary and metastatic granulosa cell tumours
Stavrinou,S, Differential expression of E-cadherin and catenins in ovarian sex cord stromal tumours
Swinyard,L, Identification of mechanism of action of anticancer genes
Syed,F, - Expression of Interleukin-8 and Il-8 receptors, CXCR-1 and CXCR-2 in pancreatic adenocarcinomas and neuroendocrine tumours
Turner,C, The role of IL8 in platinum resistance in ovarian caner.
Verdi,T, - Identification and characterisation of stem cells of the pancreas
Wang,Z, The expression of Claudins in borderline ovarian tumours
Woolf,D, EGFR mutations in ovarian borderline tumours and low grade carcinoma
Zhang,R, Exploring NTRK gene fusions in gynaecological tumours
Zhou,Y, Exploring the presence of gene fusions in granulosa cell tumours
Zoetelief Tromp,A, The role of prolactin receptor in granulosa cell tumours