Imperial College London
Portrait Picture

Professor Matthew J. Fuchter

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemistry
 
 
 
//

Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
//

Location

 

110DMolecular Sciences Research HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Fuchter:2020:10.1021/acs.jmedchem.0c00629,
author = {Fuchter, MJ},
doi = {10.1021/acs.jmedchem.0c00629},
journal = {Journal of Medicinal Chemistry},
pages = {11436--11447},
title = {On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective.},
url = {http://dx.doi.org/10.1021/acs.jmedchem.0c00629},
volume = {63},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Photopharmacology is a growing area of endeavor that employs photoswitchable ligands to allow for light-dependent pharmacological activity. By coupling light to therapeutic action, improved spatial and temporal selectivity can be achieved and subsequently harnessed for new concepts in therapy. Tremendous progress has already been made, with photopharmacological agents now reported against a wide array of target classes, and light-dependent results demonstrated in a range of live cell and animal models. Several challenges remain however, especially in order for photopharmacology to truly impact the clinical management of disease. This perspective aims to summarize these challenges, particularly with attention to the medicinal chemistry that will be unavoidably required for the further translation of these agents/approaches. By clearly defining challenges for drug hunters, it is hoped that further research into the medicinal chemistry of photopharmacological agents will be stimulated; ultimately enabling full realization of the huge potential for this exciting field.
AU  - Fuchter,MJ
DO  - 10.1021/acs.jmedchem.0c00629
EP  - 11447
PY  - 2020///
SN  - 0022-2623
SP  - 11436
TI  - On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective.
T2  - Journal of Medicinal Chemistry
UR  - http://dx.doi.org/10.1021/acs.jmedchem.0c00629
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32511922
UR  - https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00629
UR  - http://hdl.handle.net/10044/1/79933
VL  - 63
ER  -
Download