Imperial College London
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Professor Mark Gilchrist

Faculty of Medicine, Department of Infectious Disease

Professor of Practice
 
 
 
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Contact

 

m.gilchrist

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hughes:2020:jacamr/dlaa075,
author = {Hughes, S and Gilchrist, M and Heard, K and Hamilton, R and Sneddon, J},
doi = {jacamr/dlaa075},
journal = {JAC Antimicrob Resist},
title = {Treating infections caused by carbapenemase-producing Enterobacterales (CPE): a pragmatic approach to antimicrobial stewardship on behalf of the UKCPA Pharmacy Infection Network (PIN).},
url = {http://dx.doi.org/10.1093/jacamr/dlaa075},
volume = {2},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The emergence of carbapenemase-producing Enterobacterales (CPE) as a major cause of invasive infection both within the UK and internationally poses a very real concern for all providers of healthcare. The burden of morbidity and mortality associated with CPE infections is well described. The need for early, targeted, effective and safe antimicrobial therapy remains key for the management of these infected patients yet reliable antimicrobial treatment options remain scarce. In the absence of a universal treatment for these CPE invasive infections, individual treatment options tailored to susceptibilities and severity of infection are required. This working group from within the UK Clinical Pharmacy Association (UKCPA) Pharmacy Infection Network has developed evidence-based treatment recommendations to support infection specialists in managing these complex infections. A systematic review of peer-reviewed research was performed and analysed. We report consensus recommendations for the management of CPE-associated infections. The national expert panel makes therapeutic recommendations regarding the pharmacokinetic and pharmacodynamic properties of the drugs and pharmacokinetic targets, dosing, dosage adjustment and monitoring of parameters for novel and established antimicrobial therapies with CPE activity. This manuscript provides the infection specialist with pragmatic and evidence-based options for the management of CPE infections.
AU  - Hughes,S
AU  - Gilchrist,M
AU  - Heard,K
AU  - Hamilton,R
AU  - Sneddon,J
DO  - jacamr/dlaa075
PY  - 2020///
TI  - Treating infections caused by carbapenemase-producing Enterobacterales (CPE): a pragmatic approach to antimicrobial stewardship on behalf of the UKCPA Pharmacy Infection Network (PIN).
T2  - JAC Antimicrob Resist
UR  - http://dx.doi.org/10.1093/jacamr/dlaa075
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34223030
VL  - 2
ER  -
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