Imperial College London
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Professor Mark Gilchrist

Faculty of Medicine, Department of Infectious Disease

Professor of Practice
 
 
 
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Contact

 

m.gilchrist

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rimmer:2023:10.1016/j.ijid.2022.11.020,
author = {Rimmer, S and Barnacle, J and Gibani, M and Wu, M-S and Dissanayake, O and Mehta, R and Herdman, T and Gilchrist, M and Muir, D and Ebrahimsa, U and Mora-Peris, B and Dosekun, O and Garvey, L and Peters, J and Davies, F and Cooke, G and Abbara, A},
doi = {10.1016/j.ijid.2022.11.020},
journal = {International Journal of Infectious Diseases},
pages = {48--53},
title = {The clinical presentation of monkeypox: a retrospective case-control study of patients with possible or probable monkeypox in a West London cohort},
url = {http://dx.doi.org/10.1016/j.ijid.2022.11.020},
volume = {126},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: Since May 2022, cases of human monkeypox virus (hMPXV) with human-to-human cross-transmission have significantly increased in non-endemic countries. Our aim was to characterise diagnostic features of patients with confirmed and possible monkeypox to guide future risk stratification, and to describe a virtual care model.Methods: We performed a retrospective case-control study of 140 patients assessed and screened for suspected monkeypox; on hMPXV PCR testing, 70 were confirmed positive and 70 negative. Data were compared to generate odds ratios of demographic and clinical features.Results: Positive patients were predominantly cis-male (99%) and self-identified as gay, bisexual and other men who have sex with men (GBMSM) (94%). Lymphadenopathy at presentation was associated with a higher likelihood of a positive result (OR 7.69 [95% CI 3.58, 16.51]). Positive patients were more likely to have a rash affecting the genital (OR 5.38 [95% CI 2.57, 11.23]) or buttocks/perianal region (OR 3.79 [1.70, 8.45]) compared with negative controls. 79% of patients engaged with virtual ward follow-up.Conclusions: These data can inform a risk-based approach to management of suspected monkeypox in GBMSM populations. Lymphadenopathy at presentation and the location of the rash were more associated with a positive hMPXV result. Health authorities can consider a virtual ward approach in the hMPXV outbreak.
AU  - Rimmer,S
AU  - Barnacle,J
AU  - Gibani,M
AU  - Wu,M-S
AU  - Dissanayake,O
AU  - Mehta,R
AU  - Herdman,T
AU  - Gilchrist,M
AU  - Muir,D
AU  - Ebrahimsa,U
AU  - Mora-Peris,B
AU  - Dosekun,O
AU  - Garvey,L
AU  - Peters,J
AU  - Davies,F
AU  - Cooke,G
AU  - Abbara,A
DO  - 10.1016/j.ijid.2022.11.020
EP  - 53
PY  - 2023///
SN  - 1201-9712
SP  - 48
TI  - The clinical presentation of monkeypox: a retrospective case-control study of patients with possible or probable monkeypox in a West London cohort
T2  - International Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1016/j.ijid.2022.11.020
UR  - http://hdl.handle.net/10044/1/101822
VL  - 126
ER  -
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