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@article{Ndow:2022:infdis/jiab327,
author = {Ndow, G and Cessay, A and Cohen, D and Shimakawa, Y and Gore, ML and Tamba, S and Ghosh, S and Sanneh, B and Baldeh, I and Njie, R and D'Alessandro, U and Mendy, M and Thursz, M and Chemin, I and Lemoine, M},
doi = {infdis/jiab327},
journal = {Journal of Infectious Diseases},
pages = {862--870},
title = {Prevalence and clinical significance of occult hepatitis B infection in The Gambia, West Africa.},
url = {http://dx.doi.org/10.1093/infdis/jiab327},
volume = {226},
year = {2022}
}

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TY  - JOUR
AB  - BACKGROUND: Prevalence of occult hepatitis B infection (OBI) and its clinical outcomes have been poorly studied in Africa. METHOD: Using the PROLIFICA cohort, we compared the prevalence of OBI between HBsAg-negative healthy adults screened from the general population (controls) and HBsAg-negative patients with advanced liver disease (cases) and estimated the population attributable fraction for the effect of OBI on advanced liver disease. RESULTS: OBI prevalence was significantly higher among the cases (15/82, 18.3%) than in the control group (31/330, 9.4%, p=0.03). Among participants with OBI, pre-S2 mutations were detected in 5/31 (16.1%) controls and 3/14 (21.4%) cases (p=0.7).After adjusting for age, sex, and anti-HCV serology, OBI was significantly associated with advanced liver disease [OR: 2.8 (95% CI: 1.3-6.0), p=0.006]. In HBsAg-negative people, the proportions of advanced liver disease cases attributable to OBI and HCV were estimated at 12.9% (7.5-18.1%) and 16.9% (15.2-18.6%), respectively. CONCLUSION: OBI is endemic and an independent risk factor of advanced liver disease in The Gambia, West Africa. This implies that HBsAg-negative people with liver disease should be systematically screened for OBI. Moreover, the impact of infant hepatitis B immunization to prevent end-stage liver disease might be higher than previous estimates based solely on HBsAg-positivity.
AU  - Ndow,G
AU  - Cessay,A
AU  - Cohen,D
AU  - Shimakawa,Y
AU  - Gore,ML
AU  - Tamba,S
AU  - Ghosh,S
AU  - Sanneh,B
AU  - Baldeh,I
AU  - Njie,R
AU  - D'Alessandro,U
AU  - Mendy,M
AU  - Thursz,M
AU  - Chemin,I
AU  - Lemoine,M
DO  - infdis/jiab327
EP  - 870
PY  - 2022///
SN  - 0022-1899
SP  - 862
TI  - Prevalence and clinical significance of occult hepatitis B infection in The Gambia, West Africa.
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiab327
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34160616
UR  - https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab327/6308183
UR  - http://hdl.handle.net/10044/1/93186
VL  - 226
ER  -

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