Publications

BibTex format

@article{Ndow:2017:10.1371/journal.pone.0179025,
author = {Ndow, G and Gore, ML and Shimakawa, Y and Suso, P and Jatta, A and Tamba, S and Sow, A and Toure-Kane, C and Sadiq, F and Sabally, S and Njie, R and Thursz, MR and Lemoine, M},
doi = {10.1371/journal.pone.0179025},
journal = {PLOS One},
title = {Hepatitis B testing and treatment in HIV patients in The Gambia - compliance with international guidelines and clinical outcomes},
url = {http://dx.doi.org/10.1371/journal.pone.0179025},
volume = {12},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundCompliance with WHO guidelines on HBV screening and treatment in HIV-coinfected patients is often challenging in resource limited countries and has been poorly assessed in sub-Saharan Africa.MethodsBetween 2015 and 2016, we assessed physician’s compliance with WHO guidelines on HIV-HBV coinfection in the largest HIV clinic in The Gambia, and the hepatic outcomes in HIV-HBV coinfected patients as compared to randomly selected HIV-monoinfected controls.Results870 HIV-infected patients regularly seen in this clinic agreed to participate in our study. Only 187 (21.5%, 95% CI 18.8–24.3) had previously been screened for HBsAg, 23 (12.3%, 95% CI 8.0–17.9) were positive of whom none had liver assessment and only 6 (26.1%) had received Tenofovir. Our HBV testing intervention was accepted by all participants and found 94/870 (10.8%, 95% CI 8.8–13.1) positive, 78 of whom underwent full liver assessment along with 40 HBsAg-negative controls. At the time of liver assessment, 61/78 (78.2%) HIV-HBV coinfected patients received ART with 7 (11.5%) on Tenofovir and 54 (88.5%) on Lamivudine alone. HIV-HBV coinfected patients had higher APRI score compared to controls (0.58 vs 0.42, p = 0.002). HBV DNA was detectable in 52/53 (98.1%) coinfected patients with 14/53 (26.4%) having HBV DNA >20,000 IU/L. 10/12 (83.3%) had at least one detectable 3TC-associated HBV resistance, which tended to be associated with increase in liver fibrosis after adjusting for age and sex (p = 0.05).ConclusionsCompliance with HBV testing and treatment guidelines is poor in this Gambian HIV programme putting coinfected patients at risk of liver complications. However, the excellent uptake of HBV screening and linkage to care in our study suggests feasible improvements.
AU  - Ndow,G
AU  - Gore,ML
AU  - Shimakawa,Y
AU  - Suso,P
AU  - Jatta,A
AU  - Tamba,S
AU  - Sow,A
AU  - Toure-Kane,C
AU  - Sadiq,F
AU  - Sabally,S
AU  - Njie,R
AU  - Thursz,MR
AU  - Lemoine,M
DO  - 10.1371/journal.pone.0179025
PY  - 2017///
SN  - 1932-6203
TI  - Hepatitis B testing and treatment in HIV patients in The Gambia - compliance with international guidelines and clinical outcomes
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0179025
UR  - http://hdl.handle.net/10044/1/58167
VL  - 12
ER  -

Download

DrMindyGore

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)