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@article{Aune:2022:jncics/pkac072,
author = {Aune, D and Markozannes, G and Abar, L and Balducci, K and Cariolou, M and Nanu, N and Vieira, R and Anifowoshe, Y and Greenwood, DC and Clinton, S and Giovannucci, EL and Gunter, MJ and Jackson, A and Kampman, E and Lund, V and McTiernan, A and Riboli, E and Allen, K and Brockton, NT and Croker, H and Katsikioti, D and McGinley-Gieser, D and Mitrou, P and Wiseman, M and Velikova, G and Demark-Wahnefried, W and Norat, T and Tsilidis, KK and Chan, DSM},
doi = {jncics/pkac072},
journal = {JNCI Cancer Spectrum},
pages = {1--14},
title = {Physical activity and health-related quality of life in women with breast cancer: a meta-analysis},
url = {http://dx.doi.org/10.1093/jncics/pkac072},
volume = {6},
year = {2022}
}

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TY  - JOUR
AB  - Background: Physical activity (PA) is associated with improved health-related quality-of-life (HRQoL) among women with breast cancer; however, uncertainty remains regarding PA types and dose (frequency, duration, intensity) and various HRQoL measures. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to clarify whether specific types and doses of physical activity was related to global and specific domains of HRQoL, as part of the Global Cancer Update Programme, formerly known as the World Cancer Research Fund/American Institute for Cancer Research Continuous Update Project. Methods: PubMed and CENTRAL databases were searched up to August 31, 2019. Weighted mean differences (WMDs) in HRQoL scores were estimated using random effects models. An independent Expert Panel graded the evidence. Results: Seventy-nine RCTs (14,554 breast cancer patients) were included. PA interventions resulted in higher global HRQoL as measured by the Functional Assessment of Cancer Therapy-Breast, WMDs (95% confidence intervals)=5.94 (2.64-9.24, I2=59%, n=12), Functional Assessment of Cancer Therapy-General, 4.53 (1.94-7.13, I2=72%, n=18), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30, 6.78 (2.61-10.95, I2=76.3%, n=17). The likelihood of causality was considered probable that PA improves HRqoL in breast cancer survivors. Effects were weaker for physical function and mental/emotional health. Evidence regarding dose and type of PA remains insufficient for firm conclusions. Conclusion: PA results in improved global HRQoL in breast cancer survivors with weaker effects observed for physical function and mental/emotional health. Additional research is needed to define the impact of types and doses of activity on various domains of HRQoL.
AU  - Aune,D
AU  - Markozannes,G
AU  - Abar,L
AU  - Balducci,K
AU  - Cariolou,M
AU  - Nanu,N
AU  - Vieira,R
AU  - Anifowoshe,Y
AU  - Greenwood,DC
AU  - Clinton,S
AU  - Giovannucci,EL
AU  - Gunter,MJ
AU  - Jackson,A
AU  - Kampman,E
AU  - Lund,V
AU  - McTiernan,A
AU  - Riboli,E
AU  - Allen,K
AU  - Brockton,NT
AU  - Croker,H
AU  - Katsikioti,D
AU  - McGinley-Gieser,D
AU  - Mitrou,P
AU  - Wiseman,M
AU  - Velikova,G
AU  - Demark-Wahnefried,W
AU  - Norat,T
AU  - Tsilidis,KK
AU  - Chan,DSM
DO  - jncics/pkac072
EP  - 14
PY  - 2022///
SN  - 2515-5091
SP  - 1
TI  - Physical activity and health-related quality of life in women with breast cancer: a meta-analysis
T2  - JNCI Cancer Spectrum
UR  - http://dx.doi.org/10.1093/jncics/pkac072
UR  - https://academic.oup.com/jncics/article/6/6/pkac072/6874466
UR  - http://hdl.handle.net/10044/1/100806
VL  - 6
ER  -

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