Publications

BibTex format

@article{Cariolou:2023:10.1002/ijc.34324,
author = {Cariolou, M and Abar, L and Aune, D and Balducci, K and Becerra-Tomas, N and Greenwood, DC and Markozannes, G and Nanu, N and Vieira, R and Giovannucci, EL and Gunter, MJ and Jackson, AA and Kampman, E and Lund, V and Allen, K and Brockton, NT and Croker, H and Katsikioti, D and McGinley-Gieser, D and Mitrou, P and Wiseman, M and Cross, AJ and Riboli, E and Clinton, SK and McTiernan, A and Norat, T and Tsilidis, KK and Chan, DSM},
doi = {10.1002/ijc.34324},
journal = {International Journal of Cancer},
pages = {600--615},
title = {Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis},
url = {http://dx.doi.org/10.1002/ijc.34324},
volume = {152},
year = {2023}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is important to clarify the associations between modifiable lifestyle factors such as physical activity and breast cancer prognosis to enable the development of evidence-based survivorship recommendations. We performed a systematic review and meta-analyses to summarise the evidence on the relationship between postbreast cancer diagnosis physical activity and mortality, recurrence and second primary cancers. We searched PubMed and Embase through 31st October 2021 and included 20 observational studies and three follow-up observational analyses of patients enrolled in clinical trials. In linear dose-response meta-analysis of the observational studies, each 10-unit increase in metabolic equivalent of task (MET)-h/week higher recreational physical activity was associated with 15% and 14% lower risk of all-cause (95% confidence interval [CI]: 8%-22%, studies = 12, deaths = 3670) and breast cancer-specific mortality (95% CI: 4%-23%, studies = 11, deaths = 1632), respectively. Recreational physical activity was not associated with breast cancer recurrence (HR = 0.97, 95% CI: 0.91-1.05, studies = 6, deaths = 1705). Nonlinear dose-response meta-analyses indicated 48% lower all-cause and 38% lower breast cancer-specific mortality with increasing recreational physical activity up to 20 MET-h/week, but little further reduction in risk at higher levels. Predefined subgroup analyses across strata of body mass index, hormone receptors, adjustment for confounders, number of deaths, menopause and physical activity intensities were consistent in direction and magnitude to the main analyses. Considering the methodological limitations of the included studies, the independent Expert Panel concluded ‘limited-suggestive’ likelihood of causality for an association between recreational physical activity and lower risk of all-cause and breast cancer-specific mortality.
AU  - Cariolou,M
AU  - Abar,L
AU  - Aune,D
AU  - Balducci,K
AU  - Becerra-Tomas,N
AU  - Greenwood,DC
AU  - Markozannes,G
AU  - Nanu,N
AU  - Vieira,R
AU  - Giovannucci,EL
AU  - Gunter,MJ
AU  - Jackson,AA
AU  - Kampman,E
AU  - Lund,V
AU  - Allen,K
AU  - Brockton,NT
AU  - Croker,H
AU  - Katsikioti,D
AU  - McGinley-Gieser,D
AU  - Mitrou,P
AU  - Wiseman,M
AU  - Cross,AJ
AU  - Riboli,E
AU  - Clinton,SK
AU  - McTiernan,A
AU  - Norat,T
AU  - Tsilidis,KK
AU  - Chan,DSM
DO  - 10.1002/ijc.34324
EP  - 615
PY  - 2023///
SN  - 0020-7136
SP  - 600
TI  - Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.34324
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000871424100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.34324
UR  - http://hdl.handle.net/10044/1/100492
VL  - 152
ER  -

Download

ProfessorMarcGunter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)