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@article{Ugai:2023:10.1007/s00535-023-01955-2,
author = {Ugai, T and Akimoto, N and Haruki, K and Harrison, TA and Cao, Y and Qu, C and Chan, AT and Campbell, PT and Berndt, SI and Buchanan, DD and Cross, AJ and Diergaarde, B and Gallinger, SJ and Gunter, MJ and Harlid, S and Hidaka, A and Hoffmeister, M and Brenner, H and Chang-Claude, J and Hsu, L and Jenkins, MA and Lin, Y and Milne, RL and Moreno, V and Newcomb, PA and Nishihara, R and Obon-Santacana, M and Pai, RK and Sakoda, LC and Schoen, RE and Slattery, ML and Sun, W and Amitay, EL and Alwers, E and Thibodeau, SN and Toland, AE and Van, Guelpen B and Zaidi, SH and Potter, JD and Meyerhardt, JA and Giannakis, M and Song, M and Nowak, JA and Peters, U and Phipps, AI and Ogino, S},
doi = {10.1007/s00535-023-01955-2},
journal = {Journal of Gastroenterology},
pages = {229245--229245},
title = {Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases},
url = {http://dx.doi.org/10.1007/s00535-023-01955-2},
volume = {58},
year = {2023}
}

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TY  - JOUR
AB  - BACKGROUND: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments. We hypothesized that the prognostic association of colon cancer location might differ by tumor molecular characteristics. METHODS: Utilizing a consortium dataset of 13,101 colorectal cancer cases, including 2994 early-onset cases, we conducted survival analyses of detailed tumor location stratified by statuses of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF oncogenic mutation. RESULTS: There was a statistically significant trend for better colon cancer-specific survival in relation to tumor location from the cecum to sigmoid colon (Ptrend = 0.002), excluding the rectum. The prognostic association of colon location differed by MSI status (Pinteraction = 0.001). Non-MSI-high tumors exhibited the cecum-to-sigmoid trend for better colon cancer-specific survival [Ptrend < 0.001; multivariable hazard ratio (HR) for the sigmoid colon (vs. cecum), 0.80; 95% confidence interval (CI) 0.70-0.92], whereas MSI-high tumors demonstrated a suggestive cecum-to-sigmoid trend for worse survival (Ptrend = 0.020; the corresponding HR, 2.13; 95% CI 1.15-3.92). The prognostic association of colon tumor location also differed by CIMP status (Pinteraction = 0.003) but not significantly by age, stage, or other features. Furthermore, MSI-high status was a favorable prognostic indicator in all stages. CONCLUSIONS: Both detailed colonic location and tumor molecular features need to be accounted for colon cancer prognostication to advance precision medicine. Our study indicates the important role of large-scale studies to robustly examine detailed colonic subsites in molecular oncology research.
AU  - Ugai,T
AU  - Akimoto,N
AU  - Haruki,K
AU  - Harrison,TA
AU  - Cao,Y
AU  - Qu,C
AU  - Chan,AT
AU  - Campbell,PT
AU  - Berndt,SI
AU  - Buchanan,DD
AU  - Cross,AJ
AU  - Diergaarde,B
AU  - Gallinger,SJ
AU  - Gunter,MJ
AU  - Harlid,S
AU  - Hidaka,A
AU  - Hoffmeister,M
AU  - Brenner,H
AU  - Chang-Claude,J
AU  - Hsu,L
AU  - Jenkins,MA
AU  - Lin,Y
AU  - Milne,RL
AU  - Moreno,V
AU  - Newcomb,PA
AU  - Nishihara,R
AU  - Obon-Santacana,M
AU  - Pai,RK
AU  - Sakoda,LC
AU  - Schoen,RE
AU  - Slattery,ML
AU  - Sun,W
AU  - Amitay,EL
AU  - Alwers,E
AU  - Thibodeau,SN
AU  - Toland,AE
AU  - Van,Guelpen B
AU  - Zaidi,SH
AU  - Potter,JD
AU  - Meyerhardt,JA
AU  - Giannakis,M
AU  - Song,M
AU  - Nowak,JA
AU  - Peters,U
AU  - Phipps,AI
AU  - Ogino,S
DO  - 10.1007/s00535-023-01955-2
EP  - 229245
PY  - 2023///
SN  - 0944-1174
SP  - 229245
TI  - Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases
T2  - Journal of Gastroenterology
UR  - http://dx.doi.org/10.1007/s00535-023-01955-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36648535
UR  - https://link.springer.com/article/10.1007/s00535-023-01955-2
UR  - http://hdl.handle.net/10044/1/102841
VL  - 58
ER  -

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