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@article{Rothwell:2023:10.1186/s12916-023-02739-4,
author = {Rothwell, JA and Beevi, J and Dimou, N and Breeur, M and Murphy, N and Jenab, M and Wedekind, R and Viallon, V and Ferrari, P and Achaintre, D and Gicquiau, A and Rinaldi, S and Scalbert, A and Huybrechts, I and Prehn, C and Adamski, J and Cross, AJ and Keun, H and Chadeau-Hyam, M and Boutron-Ruault, M-C and Overvad, K and Dahm, CC and Nøst, TH and Sandanger, TM and Skeie, G and Zamora-Ros, R and Tsilidis, KK and Eichelmann, F and Schulze, MB and van, Guelpen B and Vidman, L and Sánchez, M-J and Amiano, P and Ardanaz, E and Smith-Byrne, K and Travis, R and Katzke, V and Kaaks, R and Derksen, JWG and Colorado-Yohar, S and Tumino, R and Bueno-de-Mesquita, B and Vineis, P and Palli, D and Pasanisi, F and Eriksen, AK and Tjønneland, A and Severi, G and Gunter, MJ},
doi = {10.1186/s12916-023-02739-4},
journal = {BMC Medicine},
pages = {1--13},
title = {Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts},
url = {http://dx.doi.org/10.1186/s12916-023-02739-4},
volume = {21},
year = {2023}
}

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TY  - JOUR
AB  - BACKGROUND: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. METHODS: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. RESULTS: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. CONCLUSIONS: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
AU  - Rothwell,JA
AU  - Beevi,J
AU  - Dimou,N
AU  - Breeur,M
AU  - Murphy,N
AU  - Jenab,M
AU  - Wedekind,R
AU  - Viallon,V
AU  - Ferrari,P
AU  - Achaintre,D
AU  - Gicquiau,A
AU  - Rinaldi,S
AU  - Scalbert,A
AU  - Huybrechts,I
AU  - Prehn,C
AU  - Adamski,J
AU  - Cross,AJ
AU  - Keun,H
AU  - Chadeau-Hyam,M
AU  - Boutron-Ruault,M-C
AU  - Overvad,K
AU  - Dahm,CC
AU  - Nøst,TH
AU  - Sandanger,TM
AU  - Skeie,G
AU  - Zamora-Ros,R
AU  - Tsilidis,KK
AU  - Eichelmann,F
AU  - Schulze,MB
AU  - van,Guelpen B
AU  - Vidman,L
AU  - Sánchez,M-J
AU  - Amiano,P
AU  - Ardanaz,E
AU  - Smith-Byrne,K
AU  - Travis,R
AU  - Katzke,V
AU  - Kaaks,R
AU  - Derksen,JWG
AU  - Colorado-Yohar,S
AU  - Tumino,R
AU  - Bueno-de-Mesquita,B
AU  - Vineis,P
AU  - Palli,D
AU  - Pasanisi,F
AU  - Eriksen,AK
AU  - Tjønneland,A
AU  - Severi,G
AU  - Gunter,MJ
DO  - 10.1186/s12916-023-02739-4
EP  - 13
PY  - 2023///
SN  - 1741-7015
SP  - 1
TI  - Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-023-02739-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36855092
UR  - https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02739-4
UR  - http://hdl.handle.net/10044/1/102784
VL  - 21
ER  -

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