Imperial College London
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ProfessorMarcGunter

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 2623m.gunter

 
 
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Location

 

VC2Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Chang:2022:10.1016/S0140-6736(22)02241-3,
author = {Chang, K and Millett, C and Rauber, F and Levy, RB and Huybrechts, I and Kliemann, N and Gunter, MJ and Vamos, EP},
doi = {10.1016/S0140-6736(22)02241-3},
title = {Ultra-processed food consumption, cancer risk, and cancer mortality: a prospective cohort study of the UK Biobank.},
url = {http://dx.doi.org/10.1016/S0140-6736(22)02241-3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - BACKGROUND: Dietary patterns worldwide are increasingly displaced by many cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). Higher UPF consumption has been linked to increased risk for obesity and cardiometabolic diseases, but prospective evidence is limited on cancer outcomes. This study aimed to examine the association between UPF consumption and risk for overall and site-specific cancer incidence and cancer mortality using the UK Biobank cohort. METHODS: 197 426 participants of the UK Biobank from England, Scotland, and Wales with 24-h dietary recall completed between 2009 and 2012 were included. Incident cancer cases were identified through data linkage to national cancer and mortality registries. Food items consumed were categorised according to their degree of food processing using the NOVA classification system. Individual UPF consumption were derived as a percentage of daily food intake. Prospective association was assessed using multivariable Cox proportional hazards models adjusted for baseline sociodemographic and lifestyle characteristics. For female-specific cancers, menopausal status, use of oral contraceptives, hormone replacement therapy, and parity were additionally adjusted. FINDINGS: Mean age was 58·0 years (SD 8·0); 54·6% of participants were women. During a median follow-up time of 9·8 years (IQR 9·4-10·6), 15 921 (8·1%) of 197 426 individuals developed cancer and 4009 (2·0%) cancer deaths were encountered. Consumption of UPFs was associated with a higher incidence of overall cancer (hazard ratio per 10% increment in UPF consumption was 1·02 [95% CI 1·01-1·04]; p=0·005) and ovarian cancer in females (1·19 [1·08-1·30]; p<0·001). Positive associations were identified for mortality of overall, breast, and ovarian cancers. INTERPRETATION: This large UK cohort study presents evidence of positive associations between
AU  - Chang,K
AU  - Millett,C
AU  - Rauber,F
AU  - Levy,RB
AU  - Huybrechts,I
AU  - Kliemann,N
AU  - Gunter,MJ
AU  - Vamos,EP
DO  - 10.1016/S0140-6736(22)02241-3
PY  - 2022///
TI  - Ultra-processed food consumption, cancer risk, and cancer mortality: a prospective cohort study of the UK Biobank.
UR  - http://dx.doi.org/10.1016/S0140-6736(22)02241-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36929975
ER  -
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