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@article{Brand:2015:humrep/dev054,
author = {Brand, JS and Onland-Moret, NC and Eijkemans, MJC and Tjonneland, A and Roswall, N and Overvad, K and Fagherazzi, G and Clavel-Chapelon, F and Dossus, L and Lukanova, A and Grote, V and Bergmann, MM and Boeing, H and Trichopoulou, A and Tzivoglou, M and Trichopoulos, D and Grioni, S and Mattiello, A and Masala, G and Tumino, R and Vineis, P and Bueno-De-Mesquita, HB and Weiderpass, E and Redondo, ML and Sanchez, MJ and Huerta, Castano JM and Arriola, L and Ardanaz, E and Duell, EJ and Rolandsson, O and Franks, PW and Butt, S and Nilsson, P and Khaw, KT and Wareham, N and Travis, R and Romieu, I and Gunter, MJ and Riboli, E and van, der Schouw YT},
doi = {humrep/dev054},
journal = {Human Reproduction},
pages = {1491--1498},
title = {Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition},
url = {http://dx.doi.org/10.1093/humrep/dev054},
volume = {30},
year = {2015}
}

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TY  - JOUR
AB  - STUDY QUESTION Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes?SUMMARY ANSWER Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause.WHAT IS KNOWN ALREADY Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health.STUDY DESIGN, SIZE, DURATION We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000.PARTICIPANTS/MATERIALS, SETTING, METHODS Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale.MAIN RESULTS AND THE ROLE OF CHANCE Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89–1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10–20 years: HR = 1.43; 95% CI 1.02–2.01, <10 years: HR = 1.59; 95% CI 1.03–2.43) compared with non-diabetic women, whereas women with diabetes at age 50 years and older had a later menopause (HR = 0.81; 95% CI 0.70–0.95). None of the other age groups were associated with ANM.LIMITATIONS, REASONS FOR CAUTION Strengths of the study include the large sample size and the broad set of potential confounders measured. However, results may have been underestimated due to survival bias. We cannot be sure about the sequence of the events in women with a late age at diabetes, as both events then occur in a short pe
AU  - Brand,JS
AU  - Onland-Moret,NC
AU  - Eijkemans,MJC
AU  - Tjonneland,A
AU  - Roswall,N
AU  - Overvad,K
AU  - Fagherazzi,G
AU  - Clavel-Chapelon,F
AU  - Dossus,L
AU  - Lukanova,A
AU  - Grote,V
AU  - Bergmann,MM
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Tzivoglou,M
AU  - Trichopoulos,D
AU  - Grioni,S
AU  - Mattiello,A
AU  - Masala,G
AU  - Tumino,R
AU  - Vineis,P
AU  - Bueno-De-Mesquita,HB
AU  - Weiderpass,E
AU  - Redondo,ML
AU  - Sanchez,MJ
AU  - Huerta,Castano JM
AU  - Arriola,L
AU  - Ardanaz,E
AU  - Duell,EJ
AU  - Rolandsson,O
AU  - Franks,PW
AU  - Butt,S
AU  - Nilsson,P
AU  - Khaw,KT
AU  - Wareham,N
AU  - Travis,R
AU  - Romieu,I
AU  - Gunter,MJ
AU  - Riboli,E
AU  - van,der Schouw YT
DO  - humrep/dev054
EP  - 1498
PY  - 2015///
SN  - 1460-2350
SP  - 1491
TI  - Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition
T2  - Human Reproduction
UR  - http://dx.doi.org/10.1093/humrep/dev054
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358015200024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/42738
VL  - 30
ER  -

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