Imperial College London
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ProfessorMartinHeeney

Faculty of Natural Sciences, Department of Chemistry

Professor of Organic Materials
 
 
 
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Contact

 

+44 (0)20 7594 1248m.heeney Website

 
 
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Location

 

401GMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Creamer:2023:10.1002/adma.202300413,
author = {Creamer, A and Lo, Fiego A and Agliano, A and Prados, Martin L and Hogset, H and Najer, A and Richards, D and Wojciechowski, J and Foote, J and Kim, N and Monahan, A and Tang, J and Shamsabadi, A and Rochet, LNC and Thanasi, IA and de, la Ballina LR and Rapley, CL and Turnock, S and Love, EA and Bugeon, L and Dallman, MJ and Heeney, M and Kramer-Marek, G and Chudasama, V and Fenaroli, F and Stevens, M},
doi = {10.1002/adma.202300413},
journal = {Advanced Materials},
pages = {1--14},
title = {Modular synthesis of semiconducting graft co-polymers to achieve ‘clickable’ fluorescent nanoparticles with long circulation and specific cancer targeting},
url = {http://dx.doi.org/10.1002/adma.202300413},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation and protein fouling in physiological conditions, which can be detrimental for in vivo applications. Here, a method for achieving colloidally stable and low-fouling SPNs is described by grafting poly(ethylene glycol) (PEG) onto the backbone of the fluorescent semiconducting polymer, poly(9,9′-dioctylfluorene-5-fluoro-2,1,3-benzothiadiazole), in a simple one-step substitution reaction, postpolymerization. Further, by utilizing azide-functionalized PEG, anti-human epidermal growth factor receptor 2 (HER2) antibodies, antibody fragments, or affibodies are site-specifically “clicked” onto the SPN surface, which allows the functionalized SPNs to specifically target HER2-positive cancer cells. In vivo, the PEGylated SPNs are found to have excellent circulation efficiencies in zebrafish embryos for up to seven days postinjection. SPNs functionalized with affibodies are then shown to be able to target HER2 expressing cancer cells in a zebrafish xenograft model. The covalent PEGylated SPN system described herein shows great potential for cancer theranostics.
AU  - Creamer,A
AU  - Lo,Fiego A
AU  - Agliano,A
AU  - Prados,Martin L
AU  - Hogset,H
AU  - Najer,A
AU  - Richards,D
AU  - Wojciechowski,J
AU  - Foote,J
AU  - Kim,N
AU  - Monahan,A
AU  - Tang,J
AU  - Shamsabadi,A
AU  - Rochet,LNC
AU  - Thanasi,IA
AU  - de,la Ballina LR
AU  - Rapley,CL
AU  - Turnock,S
AU  - Love,EA
AU  - Bugeon,L
AU  - Dallman,MJ
AU  - Heeney,M
AU  - Kramer-Marek,G
AU  - Chudasama,V
AU  - Fenaroli,F
AU  - Stevens,M
DO  - 10.1002/adma.202300413
EP  - 14
PY  - 2023///
SN  - 0935-9648
SP  - 1
TI  - Modular synthesis of semiconducting graft co-polymers to achieve ‘clickable’ fluorescent nanoparticles with long circulation and specific cancer targeting
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202300413
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202300413
UR  - http://hdl.handle.net/10044/1/103364
ER  -
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