Publications
204 results found
Baker EH, Clark N, Brennan AL, et al., 2007, Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 102, Pages: 1969-1975, ISSN: 8750-7587
- Author Web Link
- Cite
- Citations: 133
Brennan AL, Gyi KM, Wood DM, et al., 2007, Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 6, Pages: 101-109, ISSN: 1569-1993
- Author Web Link
- Cite
- Citations: 132
Simmonds NJ, MacNeill S, Cullinan P, et al., 2007, A search for factors associated with longevity in cystic fibrosis: A case control study, PEDIATRIC PULMONOLOGY, Pages: 363-363, ISSN: 8755-6863
Adeboyeku D, Scott S, Hodson ME, 2006, Open follow-up study of tobramycin nebuliser solution and colistin in patients with cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 5, Pages: 261-263, ISSN: 1569-1993
- Author Web Link
- Cite
- Citations: 19
Welch JV, Burgess J, Benlarbi M, et al., 2006, Adult cystic fibrosis lung function, nutrition, and survival at the royal brompton hospital compared with UK and US data, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II122-II122, ISSN: 0040-6376
Kapsioti K, Hodson ME, 2006, Outcome of <i>Burkholderia cepacia</i> complex pulmonary infection in patients with cystic fibrosis 1990-2004, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II34-II34, ISSN: 0040-6376
Gyi KM, Hodson ME, Yacoub MY, 2006, Pregnancy in cystic fibrosis lung transplant recipients: Case series and review, JOURNAL OF CYSTIC FIBROSIS, Vol: 5, Pages: 171-175, ISSN: 1569-1993
- Author Web Link
- Cite
- Citations: 41
Lekkas A, Gyi KM, Hodson ME, 2006, Temocillin in the treatment of <i>Burkholderia cepacia</i> infection in cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 5, Pages: 121-124, ISSN: 1569-1993
- Author Web Link
- Cite
- Citations: 19
Brennan AL, Gy KM, Wood DM, et al., 2006, Relationship between glycosylated haernoglobin and mean plasma glucose concentration in cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 5, Pages: 27-31, ISSN: 1569-1993
- Author Web Link
- Cite
- Citations: 31
Brennan AL, Gyi KM, Clark N, et al., 2005, Detection of increased glucose concentrations in lower airway secretions from people with cystic fibrosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II93-II93, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 3
Beirne PA, Banner NR, Khaghani A, et al., 2005, Lung transplantation for non-cystic fibrosis bronchiectasis: Analysis of a 13-year experience, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 24, Pages: 1530-1535, ISSN: 1053-2498
- Author Web Link
- Cite
- Citations: 22
Gordon SH, Lee MR, Smith CL, et al., 2005, Laboratory simulation of terrestrial meteorite weathering, 68th Annual Meeting of the Meteoritical-Society, Publisher: METEORITICAL SOC, Pages: A58-A58, ISSN: 1086-9379
Gyi KM, Carby MR, Hodson ME, 2005, Clinical and functional status of cystic fibrosis (CF) heart-lung transplant (HLT) recipients surviving more than ten years, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 24, Pages: S158-S158, ISSN: 1053-2498
Thaning K, Roy N, Hall AV, et al., 2005, Isolation of atypical mycobacteria in lung and heart-lung transplant recipients, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 24, Pages: S110-S110, ISSN: 1053-2498
Carby MR, Hodson ME, Banner NR, 2004, Refractory pulmonary aspergillosis treated with caspofungin after heart-lung transplantation., Transpl Int, Vol: 17, Pages: 545-548, ISSN: 0934-0874
Invasive pulmonary aspergillosis (IPA) is a serious complication of lung transplantation. Pre-mortem diagnosis is difficult and is made according to defined criteria. Most patients with a post mortem diagnosis of IPA only reach the possible or probable levels of diagnostic certainty during life. Here, we report a case of probable IPA that was refractory to conventional treatment, including amphotericin, but which responded to therapy with caspofungin. A 23-year-old man underwent heart-lung transplantation for cystic fibrosis. Ten years after transplantation he developed IPA. His condition continued to deteriorate despite treatment with itraconazole, liposomal amphotericin and flucytosine together with treatment of a concomitant infection with Pseudomonas aeruginosa. Following treatment with caspofungin there was progressive and sustained clinical and radiological improvement. No adverse reaction occurred during treatment. Caspofungin should be considered as an alternative treatment for IPA in lung transplant recipients who fail to respond to other therapy.
Kunst H, Thompson D, Hodson M, 2004, Hypertension as a marker for later development of end-stage renal failure after lung and heart-lung transplantation: a cohort study., J Heart Lung Transplant, Vol: 23, Pages: 1182-1188, ISSN: 1053-2498
BACKGROUND: Time to renal failure after transplantation is not well known and the prognosis of lung and heart-lung transplantation with respect to end-stage renal failure and related factors has not been investigated in detail. We determined the predictors of end-stage renal failure after lung or heart-lung transplant using multivariate analysis. METHODS: A cohort study of 115 adult patients transplanted between 1990 and 1995, who survived at least 5 years, was carried out. Characteristics and clinical findings, including blood pressure, creatinine clearance and immunosuppression levels of patients with end-stage renal failure, were compared with those without, initially in a univariate analysis. Then a multivariate logistic regression model was built to examine the association of predictor variables with end-stage renal failure after adjustment for confounding. RESULTS: There were 19 of 115 (16.4%) patients with end-stage renal failure, with an average time of loss of renal function of 7.6 years (95% confidence interval [CI] 6.5 to 8.7) after transplantation. There was no difference in survival between patients with end-stage renal failure and those without. Multivariate analysis showed that development of hypertension post-operatively was the only significant predictor variable (odds ratio 8.16, 95% CI 1.01 to 66.0, p = 0.04). Patients' age at transplantation, gender, underlying medical conditions and other post-transplant features were not associated with end-stage renal failure. CONCLUSIONS: Development of hypertension after lung or heart-lung transplant should be used a marker for later development of end-stage renal failure. Any hypertension should be treated energetically. Acute renal failure immediately post-operatively did not predict end-stage renal failure in this cohort of patients.
Gooding IR, Gyi KM, Hodson ME, et al., 2004, Outcomes inpatients with cystic fibrosis and variceal haemorrhage, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A90-A90, ISSN: 0017-5749
Marchac V, Equi A, Le Bihan-Benjamin C, et al., 2004, Case-control study of <i>Stenotrophomonas maltophilia</i> acquisition in cystic fibrosis patients, EUROPEAN RESPIRATORY JOURNAL, Vol: 23, Pages: 98-102, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 54
Simmonds NJ, 2004, Growing old with cystic fibrosis, Paediatric Pulmonology, North American Cystic Fibrosis Conference
Brennan AL, Geddes DG, Hodson ME, et al., 2003, 24 hour glucose monitoring and nasal glucose measurement in patients with cystic fibrosis, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 19-19, ISSN: 0040-6376
Hodson ME, McKenzie S, Harms HK, et al., 2003, Dornase alfa in the treatment of cystic fibrosis in Europe: A report from the Epidemiologic Registry of Cystic Fibrosis, PEDIATRIC PULMONOLOGY, Vol: 36, Pages: 427-432, ISSN: 8755-6863
- Author Web Link
- Cite
- Citations: 38
Pfeffer PE, Pfeffer JM, Hodson ME, 2003, The psychosocial and psychiatric side of cystic fibrosis in adolescents and adults., J Cyst Fibros, Vol: 2, Pages: 61-68, ISSN: 1569-1993
Increasing numbers of cystic fibrosis (CF) patients are surviving into adulthood. An understanding of the psychiatric and psychosocial aspects of CF in adults and adolescents is therefore more important than ever. There is a large body of evidence indicating that the psychological and psychosocial functioning of people with CF is similar to that of well people, until the disease becomes severe. However, there is also evidence that patients do suffer an increased likelihood of psychiatric problems, such as depression, and of scoring poorly on physical functioning measures of quality of life. Studies have found conflicting evidence as to any association between degree of respiratory impairment and psychological functioning. Coping styles seem to have a large effect upon the quality of life of CF patients. People with cystic fibrosis can have problems with sexuality, platonic relationships and independence. Families of patients also suffer problems, which can affect the patients themselves. Non-compliance is a complicated problem with many patients. New treatments for people with CF are emerging, such as lobe transplants from live donors and gene therapy, with possible new psychosocial problems resulting. Furthermore, older studies are becoming increasingly inapplicable as treatment and prognosis changes. Therefore, more research is needed in this field.
Carpagnano GE, Barnes PJ, Geddes DM, et al., 2003, Increased leukotriene B<sub>4</sub> and interleukin-6 in exhaled breath condensate in cystic fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 167, Pages: 1109-1112, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 107
Cairn J, Yek T, Banner NR, et al., 2003, Time-related changes in pulmonary function after conversion to tacrolimus in bronchiolitis obliterans syndrome, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 22, Pages: 50-57, ISSN: 1053-2498
- Author Web Link
- Cite
- Citations: 45
Elkin SL, Vedi S, Bord S, et al., 2002, Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 166, Pages: 1470-1474, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 76
Hodson ME, Gallagher CG, 2002, New clinical evidence from the European tobramycin trial in cystic fibrosis., J Cyst Fibros, Vol: 1, Pages: 199-202, ISSN: 1569-1993
The major cause of morbidity and mortality in patients with cystic fibrosis (CF) is respiratory disease (Penketh et al., Thorax 1987; 42: 526-532). Recent studies in the USA have shown that intermittent administration of inhaled tobramycin is beneficial to patients with CF who are chronically infected with Pseudomonas aeruginosa (Ramsey et al., N Engl J Med 1999; 340: 23-30; Ramsey et al., Proceedings of the 12th Annual North American Cystic Fibrosis Conference, 1998, Montreal, Canada; Ramsey et al., Abstract from 23rd European Cystic Fibrosis Conference, 1999, the Hague, Netherlands). In Europe, the use of nebulised colistin in patients chronically infected with P. aeruginosa is widespread. A recently published study compared the efficacy and safety of tobramycin nebuliser solution (TNS) and nebulised colistin in CF patients . One hundred and fifteen patients were randomised to receive either TNS or colistin in a multi-centre open-labelled study that assessed change from baseline in FEV(1) and sputum P. aeruginosa density. TNS produced a mean 6.7% improvement in lung function (P=0.006), whilst there was no significant improvement in the colistin-treated patients. The TNS-treated patients had a significantly greater improvement in lung function than those treated with colistin (P=0.008). The safety profile of both treatments was good. We conclude that patients treated with TNS for 1 month experience improved lung function compared with patients treated with colistin.
Hodson ME, Gallagher CG, Govan JRW, 2002, A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 20, Pages: 658-664, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 203
Shidrawi RG, Murugan N, Westaby D, et al., 2002, Emergency colonoscopy for distal intestinal obstruction syndrome in cystic fibrosis patients, GUT, Vol: 51, Pages: 285-286, ISSN: 0017-5749
- Author Web Link
- Cite
- Citations: 20
Hodson ME, Sharma R, Anker SD, 2002, Wasting as predictor of survival in CF - Reply, THORAX, Vol: 57, Pages: 468-468, ISSN: 0040-6376
Kerr JR, Martin H, Chadwick MV, et al., 2002, Evidence against transmission of <i>Pseudomonas aeruginosa</i> by hands and stethoscopes in a cystic fibrosis unit, JOURNAL OF HOSPITAL INFECTION, Vol: 50, Pages: 324-326, ISSN: 0195-6701
- Author Web Link
- Cite
- Citations: 9
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.