Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kraja:2011:10.2337/db10-1011,
author = {Kraja, AT and Vaidya, D and Pankow, JS and Goodarzi, MO and Assimes, TL and Kullo, IJ and Sovio, U and Mathias, RA and Sun, YV and Franceschini, N and Absher, D and Li, G and Zhang, Q and Feitosa, MF and Glazer, NL and Haritunians, T and Hartikainen, A-L and Knowles, JW and North, KE and Iribarren, C and Kral, B and Yanek, L and O'Reilly, PF and McCarthy, MI and Jaquish, C and Couper, DJ and Chakravarti, A and Psaty, BM and Becker, LC and Province, MA and Boerwinkle, E and Quertermous, T and Palotie, L and Jarvelin, M-R and Becker, DM and Kardia, SLR and Rotter, JI and Chen, Y-DI and Borecki, IB},
doi = {10.2337/db10-1011},
journal = {Diabetes},
pages = {1329--1339},
title = {A bivariate genome-wide approach to metabolic syndrome STAMPEED consortium},
url = {http://dx.doi.org/10.2337/db10-1011},
volume = {60},
year = {2011}
}
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TY  - JOUR
AB  - OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease. This study tests whether common genetic variants with pleiotropic effects account for some of the correlated architecture among five metabolic phenotypes that define MetS.RESEARCH DESIGN AND METHODS Seven studies of the STAMPEED consortium, comprising 22,161 participants of European ancestry, underwent genome-wide association analyses of metabolic traits using a panel of ∼2.5 million imputed single nucleotide polymorphisms (SNPs). Phenotypes were defined by the National Cholesterol Education Program (NCEP) criteria for MetS in pairwise combinations. Individuals exceeding the NCEP thresholds for both traits of a pair were considered affected.RESULTS Twenty-nine common variants were associated with MetS or a pair of traits. Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were further tested for their association with individual qualitative and quantitative traits. None of the 16 top SNPs (one per gene) associated simultaneously with more than two individual traits. Of them 11 variants showed nominal associations with MetS per se. The effects of 16 top SNPs on the quantitative traits were relatively small, together explaining from ∼9% of the variance in triglycerides, 5.8% of high-density lipoprotein cholesterol, 3.6% of fasting glucose, and 1.4% of systolic blood pressure.CONCLUSIONS Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.
AU  - Kraja,AT
AU  - Vaidya,D
AU  - Pankow,JS
AU  - Goodarzi,MO
AU  - Assimes,TL
AU  - Kullo,IJ
AU  - Sovio,U
AU  - Mathias,RA
AU  - Sun,YV
AU  - Franceschini,N
AU  - Absher,D
AU  - Li,G
AU  - Zhang,Q
AU  - Feitosa,MF
AU  - Glazer,NL
AU  - Haritunians,T
AU  - Hartikainen,A-L
AU  - Knowles,JW
AU  - North,KE
AU  - Iribarren,C
AU  - Kral,B
AU  - Yanek,L
AU  - O'Reilly,PF
AU  - McCarthy,MI
AU  - Jaquish,C
AU  - Couper,DJ
AU  - Chakravarti,A
AU  - Psaty,BM
AU  - Becker,LC
AU  - Province,MA
AU  - Boerwinkle,E
AU  - Quertermous,T
AU  - Palotie,L
AU  - Jarvelin,M-R
AU  - Becker,DM
AU  - Kardia,SLR
AU  - Rotter,JI
AU  - Chen,Y-DI
AU  - Borecki,IB
DO  - 10.2337/db10-1011
EP  - 1339
PY  - 2011///
SN  - 0012-1797
SP  - 1329
TI  - A bivariate genome-wide approach to metabolic syndrome STAMPEED consortium
T2  - Diabetes
UR  - http://dx.doi.org/10.2337/db10-1011
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289496100029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://diabetes.diabetesjournals.org/content/60/4/1329
UR  - http://hdl.handle.net/10044/1/85536
VL  - 60
ER  -
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