Imperial College London
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ProfessorMichaelJohnson

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology and Genomic Medicine
 
 
 
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Contact

 

m.johnson Website

 
 
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Location

 

E419Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Srivastava:2017:10.1523/ENEURO.0152-17.2017,
author = {Srivastava, PK and Roncon, P and Lukasiuk, K and Gorter, JA and Aronica, E and Pitkänen, A and Petretto, E and Johnson, MR and Simonato, M},
doi = {10.1523/ENEURO.0152-17.2017},
journal = {eNeuro},
title = {Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.},
url = {http://dx.doi.org/10.1523/ENEURO.0152-17.2017},
volume = {4},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data.
AU  - Srivastava,PK
AU  - Roncon,P
AU  - Lukasiuk,K
AU  - Gorter,JA
AU  - Aronica,E
AU  - Pitkänen,A
AU  - Petretto,E
AU  - Johnson,MR
AU  - Simonato,M
DO  - 10.1523/ENEURO.0152-17.2017
PY  - 2017///
SN  - 2373-2822
TI  - Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.
T2  - eNeuro
UR  - http://dx.doi.org/10.1523/ENEURO.0152-17.2017
UR  - http://hdl.handle.net/10044/1/55537
VL  - 4
ER  -
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