Imperial College London
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Dr Marika Kaakinen

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 7594 6537m.kaakinen Website

 
 
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Location

 

E301Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Macare:2018:10.1016/j.euroneuro.2018.07.101,
author = {Macare, C and Ducci, F and Zhang, Y and Ruggeri, B and Jia, T and Kaakinen, M and Kalsi, G and Charoen, P and Casoni, F and Peters, J and Bromberg, U and Hil, M and Buxton, J and Blakemore, A and Veijola, J and Buchel, C and Banaschewski, T and Bokde, ALW and Conrod, P and Flor, H and Frouin, V and Gallinat, J and Garavan, H and Gowland, PA and Heinz, A and Itternnann, B and Lathrop, M and Martinot, J-L and Paus, T and Desrivieres, S and Munafo, M and Jarvelin, M-R and Schumanna, G},
doi = {10.1016/j.euroneuro.2018.07.101},
journal = {European Neuropsychopharmacology},
pages = {1103--1114},
title = {A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response},
url = {http://dx.doi.org/10.1016/j.euroneuro.2018.07.101},
volume = {28},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N=14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p=5.0×10−4) and higher plasma cotinine levels (p=7.0×10−5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n=1,263) and with higher DRD2 gene expression in the striatum (p=0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.
AU  - Macare,C
AU  - Ducci,F
AU  - Zhang,Y
AU  - Ruggeri,B
AU  - Jia,T
AU  - Kaakinen,M
AU  - Kalsi,G
AU  - Charoen,P
AU  - Casoni,F
AU  - Peters,J
AU  - Bromberg,U
AU  - Hil,M
AU  - Buxton,J
AU  - Blakemore,A
AU  - Veijola,J
AU  - Buchel,C
AU  - Banaschewski,T
AU  - Bokde,ALW
AU  - Conrod,P
AU  - Flor,H
AU  - Frouin,V
AU  - Gallinat,J
AU  - Garavan,H
AU  - Gowland,PA
AU  - Heinz,A
AU  - Itternnann,B
AU  - Lathrop,M
AU  - Martinot,J-L
AU  - Paus,T
AU  - Desrivieres,S
AU  - Munafo,M
AU  - Jarvelin,M-R
AU  - Schumanna,G
DO  - 10.1016/j.euroneuro.2018.07.101
EP  - 1114
PY  - 2018///
SN  - 0924-977X
SP  - 1103
TI  - A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response
T2  - European Neuropsychopharmacology
UR  - http://dx.doi.org/10.1016/j.euroneuro.2018.07.101
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445764300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0924977X18302840?via%3Dihub
UR  - http://hdl.handle.net/10044/1/85449
VL  - 28
ER  -
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