Imperial College London
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DrMelpomeniKalofonou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Research Fellow in Cancer Technology
 
 
 
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Contact

 

+44 (0)20 7594 1594m.kalofonou Website CV

 
 
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Location

 

B420C - Centre for Bio-Inspired Technology (CBIT)Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Dimitrakopoulos:2019,
author = {Dimitrakopoulos, FID and Antonacopoulou, A and Kottorou, A and Tzelepi, V and Panagopoulos, M and Kalofonou, M and Dougenis, D and Koutras, A and Makatsoris, T and Kalofonos, H},
pages = {mdz073. 016--mdz073. 016},
publisher = {Oxford University Press},
title = {37P Genetic variation of lymphotoxin beta receptor (LTβR) rs10849448 (A/G) is associated with risk for lung cancer and metastatic spread to adrenals},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - BackgroundDuring the last years there is an expansion of our knowledge in lung cancer immunology. In addition, there is a growing number of studies on the role of lymphotoxin beta receptor (LTβR), a member of the tumor necrosis factor (TNF) family, which plays an important role in lymphoid system formation and homeostasis as well as in immune system regulation mainly through NF-κB signaling. The aim of the current study was to investigate the clinical relevance of LTβR single nucleotide polymorphism (SNP) rs10849448 (A/G) with the susceptibility to NSCLC, the clinicopathological parameters, the relapse and the survival rates of NSCLC patients, as well as with the protein expression of LTβR.MethodsLTβR SNP was genotyped in 268 randomly selected NSCLC patients and 279 age- and gender-matched healthy donors. Immunohistochemical analysis for LTβR was performed on 127 NSCLC tumors. The studied cohort was under observation during a five-year period.ResultsGenotype frequencies of rs10849448 (AA, AG, and GG) varied between healthy controls and patients, but the difference did not reach statistical significance (P = 0.054). AA homozygotes were found to have lower risk for NSCLC compared to G allele carriers in univariate as well as in multivariate analysis (both P = 0.016). Moreover, rs10849448 was associated with development of metastases with A allele carriers developing less often metastatic disease in adrenals (P = 0.013). Interestingly, rs10849448 was related to membranous LTβR protein expression (P = 0.035) in malignant cells, with AA homozygotes being associated with higher protein levels.ConclusionsThe present findings suggest that the investigated SNP rs10849448 may be associated with NSCLC initiation as well as with the development of metastatic disease. More association and functional studies are needed in order to further clarify it’s role in NSCLC.
AU  - Dimitrakopoulos,FID
AU  - Antonacopoulou,A
AU  - Kottorou,A
AU  - Tzelepi,V
AU  - Panagopoulos,M
AU  - Kalofonou,M
AU  - Dougenis,D
AU  - Koutras,A
AU  - Makatsoris,T
AU  - Kalofonos,H
EP  - 016
PB  - Oxford University Press
PY  - 2019///
SP  - 073
TI  - 37P Genetic variation of lymphotoxin beta receptor (LTβR) rs10849448 (A/G) is associated with risk for lung cancer and metastatic spread to adrenals
ER  -
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