Publications
16 results found
Ruth E, Heraghty F, Flynn N, et al., 2023, No evidence of isotretinoin sensitization in peanut-allergic children: a cross-sectional study, BRITISH JOURNAL OF DERMATOLOGY, Vol: 189, Pages: 481-482, ISSN: 0007-0963
Kelleher MM, Trujillo J, Byrne A, et al., 2023, Don't put all your eggs (and milk) in one basket., J Allergy Clin Immunol Pract, Vol: 11, Pages: 1981-1982
Bradshaw LE, Wyatt LA, Brown SJ, et al., 2023, Emollients for prevention of atopic dermatitis: 5-year findings from the BEEP randomized trial, ALLERGY, Vol: 78, Pages: 995-1006, ISSN: 0105-4538
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- Citations: 6
Kelleher MM, Cro S, Phillips R, et al., 2022, Correspondence to " Emollients in infancy to prevent atopic dermatitis: A systematic review and meta-analysis", Allergy, Vol: 77, Pages: 1931-1933, ISSN: 0105-4538
Byrne A, Kelleher MM, Hourihane JO, 2022, BSACI 2021 guideline for the management of egg allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 585-585, ISSN: 0954-7894
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- Citations: 1
Van Vogt E, Cro S, Cornelius VR, et al., 2021, Individual participant data meta-analysis versus aggregate data meta-analysis: a case study in eczema and food allergy prevention., Clinical and Experimental Allergy, Vol: 52, ISSN: 0954-7894
INTRODUCTION: Meta-analysis traditionally uses aggregate data from published reports. Individual Participant Data (IPD) meta-analysis, which obtains and synthesises participant-level data, is potentially more informative, but resource-intensive. The impact on the findings of meta-analyses using IPD in comparison to aggregate data has rarely been formally evaluated. METHODS: We conducted a secondary analysis of a Cochrane systematic review of skin care interventions for preventing eczema and food allergy in infants to identify the impact of the analytical choice on the review's findings. We used aggregate data meta-analysis only and contrasted the results against those of the originally published IPD meta-analysis. All meta-analysis used random effects inverse variance models. Certainty of evidence was evaluated using GRADE. RESULTS: The pooled treatment effects for the Cochrane systematic review's co-primary outcomes of eczema and food allergy were similar in IPD meta-analysis (eczema RR 1.03, 95% CI 0.81, 1.31; I2 41%, 7 studies 3075 participants), and aggregate meta-analysis (eczema RR 1.01 95% CI 0.77, 1.33; I2 53%, 7 studies, 3089 participants). In aggregate meta-analysis the statistical heterogeneity could not be explained but using IPD it was explained by one trial which used a different, bathing intervention. For IPD meta-analysis, risk of bias was assessed as lower and more adverse event data were available compared with aggregate meta-analysis. This resulted in higher certainty of evidence, especially for adverse events. IPD meta-analysis enabled analysis of treatment interactions by age and hereditary eczema risk; and analysis of the effect of treatment adherence using pooled complier-adjusted-causal-effect analysis, none of which was possible in aggregate meta-analysis. CONCLUSIONS: For this systematic review, IPD did not significantly change primary outcome risk ratios compared with aggregate data meta-analysis. However, certainty of evidence, safety out
Kelleher MM, Cro S, Van Vogt E, et al., 2021, Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta-analysis, Clinical and Experimental Allergy, Vol: 51, Pages: 402-418, ISSN: 0954-7894
ObjectiveEczema and food allergy start in infancy and have shared genetic risk factors that affect skin barrier. We aimed to evaluate whether skincare interventions can prevent eczema or food allergy.DesignA prospectively planned individual participant data meta‐analysis was carried out within a Cochrane systematic review to determine whether skincare interventions in term infants prevent eczema or food allergy.Data sourcesCochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and trial registries to July 2020.Eligibility criteria for selected studiesIncluded studies were randomized controlled trials of infants <1 year with healthy skin comparing a skin intervention with a control, for prevention of eczema and food allergy outcomes between 1 and 3 years.ResultsOf the 33 identified trials, 17 trials (5823 participants) had relevant outcome data and 10 (5154 participants) contributed to IPD meta‐analysis. Three of seven trials contributing to primary eczema analysis were at low risk of bias, and the single trial contributing to primary food allergy analysis was at high risk of bias. Interventions were mainly emollients, applied for the first 3–12 months. Skincare interventions probably do not change risk of eczema by age 1–3 years (RR 1.03, 95% CI 0.81, 1.31; I2=41%; moderate certainty; 3075 participants, 7 trials). Sensitivity analysis found heterogeneity was explained by increased eczema in a trial of daily bathing as part of the intervention. It is unclear whether skincare interventions increase risk of food allergy by age 1–3 years (RR 2.53, 95% CI 0.99 to 6.47; very low certainty; 996 participants, 1 trial), but they probably increase risk of local skin infections (RR 1.34, 95% CI 1.02, 1.77; I2=0%; moderate certainty; 2728 participants, 6 trials).ConclusionRegular emollients during infancy probably do not prevent eczema and probably increase local skin infections.
Chalmers JR, Haines RH, Bradshaw LE, et al., 2020, Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial, The Lancet, Vol: 395, Pages: 962-972, ISSN: 0140-6736
BackgroundSkin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children.MethodsWe did a multicentre, pragmatic, parallel-group, randomised controlled trial in 12 hospitals and four primary care sites across the UK. Families were approached via antenatal or postnatal services for recruitment of term infants (at least 37 weeks' gestation) at high risk of developing eczema (ie, at least one first-degree relative with parent-reported eczema, allergic rhinitis, or asthma, diagnosed by a doctor). Term newborns with a family history of atopic disease were randomly assigned (1:1) to application of emollient daily (either Diprobase cream or DoubleBase gel) for the first year plus standard skin-care advice (emollient group) or standard skin-care advice only (control group). The randomisation schedule was created using computer-generated code (stratified by recruiting centre and number of first-degree relatives with atopic disease) and participants were assigned to groups using an internet-based randomisation system. The primary outcome was eczema at age 2 years (defined by UK working party criteria) with analysis as randomised regardless of adherence to allocation for participants with outcome data collected, and adjusting for stratification variables. This trial is registered with ISRCTN, ISRCTN21528841. Data collection for long-term follow-up is ongoing, but the trial is closed to recruitment.Findings1394 newborns were randomly assigned to study groups between Nov 19, 2014, and Nov 18, 2016; 693 were assigned to the emollient group and 701 to the control group. Adherence in the emollient group was 88% (466 of 532) at 3 months, 82% (427 of 519) at 6 months, and 74% (375 of 506) at 12 months in those with complete questionnaire data. At age 2 years, eczema was present in 139 (23%) of 598 infants with outcome data collected in the emollient group and 150 (25%) of 612 infants in the co
Kelleher MM, Jay N, Perkin MR, et al., 2020, An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 50, Pages: 334-342, ISSN: 0954-7894
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- Citations: 15
Kelleher MM, Jay N, Perkin MR, et al., 2019, A novel approach to food allergy diagnosis within a primary prevention trial, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY, Pages: 151-151, ISSN: 0105-4538
O'Connor C, Hourihane J, 2016, Calculating the effect of population-level implementation of the Learning Early About Peanut Allergy (LEAP) protocol to prevent peanut allergy., Journal of Allergy and Clinical Immunology, ISSN: 0091-6749
Kelleher MM, Dunn-Galvin A, Gray C, et al., 2016, Skin barrier impairment at birth predicts food allergy at 2 years of age., Journal of Allergy and Clinical Immunology, ISSN: 0091-6749
Kelleher MM, Dunn-Galvin A, Hourihane J, et al., 2015, Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year., Journal of Allergy and Clinical Immunology, ISSN: 0091-6749
Kelleher MM, DunnGalvin A, Sheikh A, et al., 2013, Twenty four-hour helpline access to expert management advice for food-allergy-triggered anaphylaxis in infants, children and young people: a pragmatic, randomized controlled trial, Allergy, Vol: 68, Pages: 1598-1604, ISSN: 0105-4538
Kelleher MM, O'Carroll M, Gallagher A, et al., 2013, Newborn Transepidermal Water Loss Values: A Reference Dataset, Pediatric Dermatology, Vol: 30, Pages: 712-716, ISSN: 0736-8046
<jats:title>Abstract</jats:title><jats:p>Transepidermal water loss (<jats:styled-content style="fixed-case">TEWL</jats:styled-content>) is a simple noninvasive measurement of inside‐out skin barrier function. The goal of this research was to establish normal values for <jats:styled-content style="fixed-case">TEWL</jats:styled-content> in early life using data gathered from the Cork <jats:styled-content style="fixed-case">BASELINE</jats:styled-content> Birth Cohort Study. <jats:styled-content style="fixed-case">TEWL</jats:styled-content> was recorded in a standardized fashion using a well‐validated open‐chamber system. A mean of three readings was recorded from 1,036 neonates (37–42 weeks gestational age) and 18 late preterm infants (34–37 weeks gestational age) within 96 hours of birth in an environmentally controlled room. Full‐term neonatal <jats:styled-content style="fixed-case">TEWL</jats:styled-content> measurements have a normal distribution (mean 7.06 ± 3.41 g of water/m<jats:sup>2</jats:sup> per hour) and mean preterm neonatal <jats:styled-content style="fixed-case">TEWL</jats:styled-content> measurements were 7.76 ± 2.85 g of water/m<jats:sup>2</jats:sup> per hour. This is the largest evaluation to date of <jats:styled-content style="fixed-case">TEWL</jats:styled-content> in a normal‐term neonatal population. It therefore constitutes a reference dataset for this measurement using an open‐chamber system.</jats:p>
Kelleher MM, Hourihane JO, DunnGalvin A, et al., 2012, A 24-h helpline for access to expert management advice for food allergy-related anaphylaxis in children: protocol for a pragmatic randomised controlled trial, BMJ Open, Vol: 2, Pages: e001282-e001282, ISSN: 2044-6055
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