Dr Kinali has collaborated with various specialties clinicians and scientists to address the full scope of problems affecting the muscle, brain, spine and nervous system.
Natural history studies:
She has worked on the characterisation of the natural history of different neuromuscular disorders and their complications. Work from her MD thesis describes in detail some of the commonest complications of DMD such as scoliosis.
The mechanisms of development of cardiomyopathy in patients with muscular dystrophy are complicated and not fully investigated. in Dr Kinali's MD thesis she looked into the myocardial tissue Doppler velocities.
She has also been involved in studying the primary myocardial dysfunction in Autosomal Dominant EDMD by using a Tissue Doppler and Cardiovascular Magnetic Resonance Study. She has also been involved in studying the Vascular Smooth Muscle dysfunction in patients with Limb girdle Muscular Dystrophies due to sarcoglycan deficiencies.
Another area that has received particular attention in her work is a variety of pharmacological interventions that could be offered and supportive measures to individuals with neuromuscular disorders. To this extent she has looked at the effect an intermittent steroid regime in DMD both in the short and long-term; the effect of salbutamol and phenylbutyrate in spinal muscular atrophy; the effect of serial casting of the ankles as an alternative to surgery in DMD.
She is also interested in the optimisation of diagnostic tools for neuromuscular disorders. To this extent she has further optimised an existing short muscle MRI protocol to correlate muscle imaging with muscle histology (on-going work). This work helps to identify the best preserved muscle to be studied by using non-invasive methods for ongoing and future clinical trials.
Due to Dr Kinali's interest in translational research she also helped to set up a Rare Diseases biological samples bank (biobank) for research to facilitate pharmacological, gene and cell therapy trials in neuromuscular disorders (NMD) at the Hammersmith Trust. This Biobank initiative has now been expanded to include several other trusts.
While animal studies have boosted the development of novel therapies in the neuromuscular (NMD) field, a bottleneck is the availability of cell lines from patients to test if these therapeutic strategies might work in the human. The objective of this project was therefore to create an abundance of tissue and cell lines by establishing a biological bank for different NMD to facilitate our current effort in translational research (research from the bench to the bedside) and future clinical trials in NMD. Dr Kinali was the named person for obtaining consent/assent for the Biobank at the Hammersmith Hospital.