Dr Marina Kuimova received a M.Sc. in Chemistry from Moscow State University in 2001, and a Ph.D from Nottingham University in 2005. She is currently a Reader (Associate Professor) in the Department of Chemistry.
My research interests include elucidation of biologically relevant processes using different types of fluorescence imaging and time-resolved spectroscopy. The detailed description of my research activities can be found here
The popular article and the video clip where I talk to the media can be found here.
For a bit of fun, read the NatureChem 'The Sceptical Chymist' blog entry here
We are always looking to recruit talented and dedicated scientists. If you are interested in joining the group, please get in touch! It is likely that the funding for one or more PhD projects will be available for the 2018/2019 start date.
Funded positions will be advertised here when available
Welcome to the new people joining the group: Jeff Lam (MSci), Miguel Paez Perez (PhD), Dr Peter Summers, Dr Raju Laishram and Dr Ajesh Thomas!
Marketa is one of the winners of an EPSRC Doctoral Prize Fellowship, which she will start in the group on the 1st October. Congratulations to Marketa!
Our new paper entitled 'Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors' has appeared on the cover of PCCP. Here we explore the effect of temperature on several BODIPY molecular rotors, with somewhat unexpected results!
Our study of the effect of temperature on the functioning of porphyrin dimer-based molecular rotors is published here: 'Tuning the Sensitivity of Fluorescent Porphyrin Dimers to Viscosity and Temperature'. Please check our frontispiece of Chem Eur J.
Congratulations to Aurimas (lead author) on both papers and an excellent support team from the group: Dong, Maryam and Ismael!
Our new paper entitled 'Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors' has appeared in Biomaterials. Here we studied the aggregation of Amyloid Beta and other aggregating proteins using covalently attached molecular rotors.
Congratulations to Marketa!
Our bid for Imperial Excellence Fund for Frontier Research in collaboration with Prof Ramon Vilar and Dr Jean-Baptiste Vannier was successful! Read about 'Searching for DNA quadruplexes' here.
Thanos Athanasiadis has successfully defended his PhD Thesis. Congratulations to Thanos!
Mike Dent has successfully defended his PhD Thesis. Congratulations to Mike!
Aurimas has successfully defended his PhD Thesis. He has also started an EPSRC Doctoral Prize Fellowship in the group on the 1st October. Congratulations to Aurimas!
Marketa Kubankova won the best talk prize in the Imaging, Sensing and Analytical Chemistry Section' of the final year postgraduate symposium at Imperial. Congratulations to Marketa!
Our new paper entitled 'Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging' has appeared in Chemical Science. Here we report imaging of microscopic viscosity in model atmospheric aerosols.
Our new paper entitled 'Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors' has appeared in Chemical Science. Here we report simultaneous imaging of viscosity and temperature using a single fluorophore.
Also please read about a red-emitting BODIPY-based temperature sensor, working via FLIM, here
Our new paper entitled 'Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors' has appeared in PCCP. Check it out for comparison between molecular rotors, FCS and MD simulations to calculate the viscosity of membranes. Congratulations to Mike and Ismael!
Aurimas Vysniauskas won the best talk prize in the 'Physical and Analytical Section' of the final year postgraduate symposium at Imperial. Congratulations to Aurimas!
N. A. Hosny et al Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging, Chem. Sci., 2016, 7, 1357-1367
T.T. Vu et al Tuning BODIPY molecular rotors into the red: sensitivity to viscosity vs temperature, J. Mater. Chem. C, 2016, 4, 2828 - 2833
A. Shivalingam, et al The interactions between a small molecule and G-quadruplexes are visualised by fluorescence lifetime imaging microscopy. Nature Commun., 2015, 6, 8178
A. Vysniauskas et al Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors, Chem Sci., 2015, DOI: 10.1039/C5SC02248G
I. Lopez-Duarte, T. T. Vu, et al A molecular rotor for measuring viscosity in plasma membranes of live cells, Chem. Commun., 2014, DOI: 10.1039/C3CC47530A (Emerging investigators issue)
Neveen A. Hosny et al Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors, PNAS, 2013
M.K. Kuimova Mapping viscosity in cells using molecular rotors, PCCP, 2012, 14, 12671-12686
M. K. Kuimova, S. W. Botchway, A. W. Parker, M. Balaz, H. A. Collins, H. L. Anderson, K. Suhling, P. R. Ogilby, Imaging Intracellular Viscosity of a Single Cell During Photoinduced Cell Death, Nature Chem., 2009, 1, 69
et al., 2016, Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles., Biomaterials, Vol:113, Pages:105-117
et al., 2018, Surface functionalisation with viscosity-sensitive BODIPY molecular rotor, Methods and Applications in Fluorescence, Vol:6, ISSN:2050-6120
et al., 2018, An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles., Acs Nano, Vol:12, Pages:4398-4407
et al., 2017, Live Cell Imaging of Viscosity in 3D Tumour Cell Models., Adv Exp Med Biol, Vol:1035, ISSN:0065-2598, Pages:143-153
et al., 2018, Rotor-Based Organelle Viscosity Imaging, 62nd Annual Meeting of the Biophysical-Society, CELL PRESS, Pages:548A-548A, ISSN:0006-3495