Imperial College London

Dr Kuimova

Faculty of Natural SciencesDepartment of Chemistry

Reader in Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

134bChemistrySouth Kensington Campus

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Summary

 

Summary

Dr Marina Kuimova received a M.Sc. in Chemistry from Moscow State University in 2001, and a Ph.D from Nottingham University in 2005.   She is currently a Reader (Associate Professor) in the Department of Chemistry.


RESEARCH


My research interests include elucidation of biologically relevant processes using different types of fluorescence imaging and time-resolved spectroscopy. The detailed description of my research activities can be found here

The popular article and the video clip where I talk to the media can be found here.

For a bit of fun, read the NatureChem 'The Sceptical Chymist' blog entry here

OPPORTUNITIES


 

We are always looking to recruit talented and dedicated scientists. If you are interested in joining the group, please get in touch! It is likely that the funding for one or more PhD projects will be available for the 2019/2020 start date.


Prospective PhD students please take note of

The President's PhD Scholarship Scheme 

Chemistry Doctoral Scholarships scheme.

The China Scholarship Council (CSC) Scheme

The Imperial Marshall Scholarship Scheme

The Schrodinger Scholarship Scheme

Funded positions will be advertised here when available


NEWS


 

*Sep 2018:
Our new review on un-mixing of the temperature-viscosity sensitivity of molecular rotors has been published! A. Vysniauskas and M. K. Kuimova, A twisted tale: measuring viscosity and temperature of microenvironments using molecular rotors, International Reviews Phys Chem, 2018


*April 2018:
Our new paper An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles has appeared in ASC Nano.

Congratulations to the joint first authors Joe and Marketa!

Also read about Surface functionalisation with viscosity-sensitive BODIPY molecular rotor, published in MAF journal

Congratulations to Aurimas and Ismael, with excellent support from Alex!

*October-November 2017: 
Welcome to the new people joining the group: Jeff Lam (MSci), Miguel Paez Perez (PhD), Dr Peter Summers, Dr Raju Laishram and Dr Ajesh Thomas!

*July 2017: 
Marketa is one of the winners of an EPSRC Doctoral Prize Fellowship, which she will start in the group on the 1st October. Congratulations to Marketa!

*July 2017:
Our new paper entitled 'Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors' has appeared on the cover of PCCP. Here we explore the effect of temperature on several BODIPY molecular rotors, with somewhat unexpected results!

Our study of the effect of temperature on the functioning of porphyrin dimer-based molecular rotors is published here: 'Tuning the Sensitivity of Fluorescent Porphyrin Dimers to Viscosity and Temperature'. Please check our frontispiece of Chem Eur J.

Congratulations to Aurimas (lead author) on both papers and an excellent support team from the group: Dong, Maryam and Ismael!

*June 2017:
Our new paper entitled 'Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors' has appeared in Biomaterials. Here we studied the aggregation of Amyloid Beta and other aggregating proteins using covalently attached molecular rotors.

Congratulations to Marketa!

*March 2017: 
Our bid for Imperial Excellence Fund for Frontier Research in collaboration with Prof Ramon Vilar and Dr Jean-Baptiste Vannier was successful! Read about 'Searching for DNA quadruplexes' here.

*February 2017: 
Thanos Athanasiadis has successfully defended his PhD Thesis. Congratulations to Thanos!

*November 2016: 
Mike Dent has successfully defended his PhD Thesis. Congratulations to Mike!

*October 2016: 
Aurimas has successfully defended his PhD Thesis. He has also started an EPSRC Doctoral Prize Fellowship in the group on the 1st October. Congratulations to Aurimas!

*July 2016:
Marketa Kubankova won the best talk prize in the Imaging, Sensing and Analytical Chemistry Section' of the final year postgraduate symposium at Imperial. Congratulations to Marketa!

*March 2016:
Our new paper entitled 'Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging' has appeared in Chemical Science. Here we report imaging of microscopic viscosity in model atmospheric aerosols.

A recent developement on this technioque, enabling optical levitation of aerosol particles under investigation, has been published in PCCP1 and PCCP2. 

*August-July 2015:
Our new paper entitled 'Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors' has appeared in Chemical Science. Here we report simultaneous imaging of viscosity and temperature using a single fluorophore.

Also please read about a red-emitting BODIPY-based temperature sensor, working via FLIM, here

*July 2015:
Our new paper entitled 'Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors' has appeared in PCCP. Check it out for comparison between molecular rotors, FCS and MD simulations to calculate the viscosity of membranes. Congratulations to Mike and Ismael!

*June 2015:
Aurimas Vysniauskas won the best talk prize in the 'Physical and Analytical Section' of the final year postgraduate symposium at Imperial. Congratulations to Aurimas!


SELECTED PUBLICATIONS


A. Vysniauskas and M. K. Kuimova, A twisted tale: measuring viscosity and temperature of microenvironments using molecular rotors, International Reviews Phys Chem, 2018 A REVIEW!

J. E. Chambers, M. Kubankova et al, An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles ASC Nano, 2018, 12 (5), 4398-4407

P. Sherin et al, Visualising the membrane viscosity of porcine eye lens cells using molecular rotors, Chem Sci 2017

M. Kubankova et al, 'Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors', Biomaterials 2017.

L. E. Shimolina et al, Imaging tumor microscopic viscosity in vivo using molecular rotors, Sci Reports 2017

mice

N. A. Hosny et al Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging, Chem. Sci., 2016, 7, 1357-1367

aerosol

A. Shivalingam, et al The interactions between a small molecule and G-quadruplexes are visualised by fluorescence lifetime imaging microscopy. Nature Commun., 2015, 6, 8178

g4
 
 
 

A. Vysniauskas et al Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors, Chem Sci., 2015, DOI: 10.1039/C5SC02248G

pic

I. Lopez-Duarte, T. T. Vu, et al A molecular rotor for measuring viscosity in plasma membranes of live cells, Chem. Commun., 2014, DOI: 10.1039/C3CC47530A (Emerging investigators issue)

fig

 

 

 

 

 

 

Neveen A. Hosny et al Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors, PNAS, 2013

picture

 

M.K. Kuimova Mapping viscosity in cells using molecular rotors, PCCP, 2012, 14, 12671-12686 A REVIEW!

 PCCP

M. K. Kuimova, S. W. Botchway, A. W. Parker, M. Balaz, H. A. Collins, H. L. Anderson, K. Suhling, P. R. Ogilby, Imaging Intracellular Viscosity of a Single Cell During Photoinduced Cell Death, Nature Chem., 2009, 1, 69 

cell death

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Publications

Journals

Vysniauskas A, Kuimova MK, 2018, A twisted tale: measuring viscosity and temperature of microenvironments using molecular rotors, International Reviews in Physical Chemistry, Vol:37, ISSN:0144-235X, Pages:259-285

Vysniauskas A, Lopez-Duarte I, Thompson AJ, et al., 2018, Surface functionalisation with viscosity-sensitive BODIPY molecular rotor, Methods and Applications in Fluorescence, Vol:6, ISSN:2050-6120

Chambers JE, Kubankova M, Huber RG, et al., 2018, An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles, Acs Nano, Vol:12, ISSN:1936-0851, Pages:4398-4407

Conference

Clark R, Edel J, Kirchner B, et al., 2018, Ion diffusion in ionic liquids in electric fields, 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, AMER CHEMICAL SOC, ISSN:0065-7727

Kubankova M, Chambers JE, Marciniak SJ, et al., 2018, Rotor-Based Organelle Viscosity Imaging, 62nd Annual Meeting of the Biophysical-Society, CELL PRESS, Pages:548A-548A, ISSN:0006-3495

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