Imperial College London

Dr Kuimova

Faculty of Natural SciencesDepartment of Chemistry

Reader in Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

207BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fitzgerald:2016:10.1039/c6cp03674k,
author = {Fitzgerald, C and Hosny, NA and Tong, H and Seville, PC and Gallimore, PJ and Davidson, NM and Athanasiadis, A and Botchway, SW and Ward, AD and Kalberer, M and Kuimova, MK and Pope, FD},
doi = {10.1039/c6cp03674k},
journal = {Physical Chemistry Chemical Physics},
pages = {21710--21719},
title = {Fluorescence lifetime imaging of optically levitated aerosol: a technique to quantitatively map the viscosity of suspended aerosol particles},
url = {http://dx.doi.org/10.1039/c6cp03674k},
volume = {18},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - We describe a technique to measure the viscosity of stably levitated single micron-sized aerosol particles. Particle levitation allows the aerosol phase to be probed in the absence of potentially artefact-causing surfaces. To achieve this feat, we combined two laser based techniques: optical trapping for aerosol particle levitation, using a counter-propagating laser beam configuration, and fluorescent lifetime imaging microscopy (FLIM) of molecular rotors for the measurement of viscosity within the particle. Unlike other techniques used to measure aerosol particle viscosity, this allows for the non-destructive probing of viscosity of aerosol particles without interference from surfaces. The well-described viscosity of sucrose aerosol, under a range of relative humidity conditions, is used to validate the technique. Furthermore we investigate a pharmaceutically-relevant mixture of sodium chloride and salbutamol sulphate under humidities representative of in vivo drug inhalation. Finally, we provide a methodology for incorporating molecular rotors into already levitated particles, thereby making the FLIM/optical trapping technique applicable to real world aerosol systems, such as atmospheric aerosols and those generated by pharmaceutical inhalers.
AU - Fitzgerald,C
AU - Hosny,NA
AU - Tong,H
AU - Seville,PC
AU - Gallimore,PJ
AU - Davidson,NM
AU - Athanasiadis,A
AU - Botchway,SW
AU - Ward,AD
AU - Kalberer,M
AU - Kuimova,MK
AU - Pope,FD
DO - 10.1039/c6cp03674k
EP - 21719
PY - 2016///
SN - 1463-9084
SP - 21710
TI - Fluorescence lifetime imaging of optically levitated aerosol: a technique to quantitatively map the viscosity of suspended aerosol particles
T2 - Physical Chemistry Chemical Physics
UR - http://dx.doi.org/10.1039/c6cp03674k
UR - http://hdl.handle.net/10044/1/38412
VL - 18
ER -