Imperial College London

Dr Kuimova

Faculty of Natural SciencesDepartment of Chemistry

Reader in Chemical Physics
 
 
 
//

Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
//

Location

 

207BMolecular Sciences Research HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Davidson:2017:10.1016/j.ijpharm.2017.01.051,
author = {Davidson, N and Tong, H-J and Kalberer, M and Seville, PC and Ward, AD and Kuimova, MK and Pope, FD},
doi = {10.1016/j.ijpharm.2017.01.051},
journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
pages = {59--69},
title = {Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung},
url = {http://dx.doi.org/10.1016/j.ijpharm.2017.01.051},
volume = {520},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Particle inhalation is an effective and rapid delivery method for a variety of pharmaceuticals, particularly bronchodilation drugs used for treating asthma and COPD. Conditions of relative humidity and temperature inside the lungs are generally very different from the outside ambient air, with the lung typically being warmer and more humid. Changes in humidity, from inhaler to lung, can cause hygroscopic phase transitions and particle growth. Increasing particle size and mass can negatively affect particle deposition within the lung leading to inefficient treatment, while deliquescence prior to impaction is liable to accelerate drug uptake. To better understand the hygroscopic properties of four pharmaceutical aerosol particles; pharmaceutical particles from four commercially available pressurised metered dose inhalers (pMDIs) were stably captured in an optical trap, and their composition was examined online via Raman spectroscopy. Micron-sized particles of salbutamol sulfate, salmeterol xinafoate, fluticasone propionate and ciclesonide were levitated and examined over a range of relative humidity values inside a chamber designed to mimic conditions within the respiratory tract. The effect of temperature upon hygroscopicity was also investigated for salbutamol sulfate particles. Salbutamol sulfate was found to have significant hygroscopicity, salmeterol xinafoate showed some hygroscopic interactions, whilst fluticasone propionate and ciclesonide revealed no observable hygroscopicity. Thermodynamic and structural modelling is used to explain the observed experimental results.
AU - Davidson,N
AU - Tong,H-J
AU - Kalberer,M
AU - Seville,PC
AU - Ward,AD
AU - Kuimova,MK
AU - Pope,FD
DO - 10.1016/j.ijpharm.2017.01.051
EP - 69
PY - 2017///
SN - 0378-5173
SP - 59
TI - Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung
T2 - INTERNATIONAL JOURNAL OF PHARMACEUTICS
UR - http://dx.doi.org/10.1016/j.ijpharm.2017.01.051
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396948400007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/46127
VL - 520
ER -