Imperial College London

Dr Kuimova

Faculty of Natural SciencesDepartment of Chemistry

Reader in Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

207BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vysniauskas:2018:2050-6120/aabb2c,
author = {Vysniauskas, A and Lopez, Duarte I and Thompson, AJ and Bull, JA and Kuimova, MK},
doi = {2050-6120/aabb2c},
journal = {Methods and Applications in Fluorescence},
title = {Surface functionalisation with viscosity-sensitive BODIPY molecular rotor},
url = {http://dx.doi.org/10.1088/2050-6120/aabb2c},
volume = {6},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Surface functionalisation with viscosity sensitive dyes termed ‘molecular rotors’ can potentially open up new opportunities in sensing, for example for non-invasive biological viscosity imaging, in studying the effect of shear stress on lipid membranes and in cells, and in imaging contacts between surfaces upon applied pressure. We have functionalised microscope slides with BODIPY-based molecular rotor capable of viscosity sensing via its fluorescence lifetime. We have optimised functionalisation conditions and prepared the slides with the BODIPY rotor attached directly to the surface of glass slides and through polymer linkers of 5 kDa and 40 kDa in mass. The slides were characterised for their sensitivity to viscosity, and used to measure viscosity of supported lipid bilayers during photooxidation, and of giant unilamellar vesicles lying on the surface of the slide. We conclude that our functionalised slides show promise for a variety of viscosity sensing applications.
AU - Vysniauskas,A
AU - Lopez,Duarte I
AU - Thompson,AJ
AU - Bull,JA
AU - Kuimova,MK
DO - 2050-6120/aabb2c
PY - 2018///
SN - 2050-6120
TI - Surface functionalisation with viscosity-sensitive BODIPY molecular rotor
T2 - Methods and Applications in Fluorescence
UR - http://dx.doi.org/10.1088/2050-6120/aabb2c
UR - http://hdl.handle.net/10044/1/57554
VL - 6
ER -