Imperial College London
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Professor Marina Kuimova

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

207BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paez-Perez:2021:10.1039/d0sc05874b,
author = {Paez-Perez, M and Lopez-Duarte, I and Vysniauskas, A and Brooks, NJ and Kuimova, MK},
doi = {10.1039/d0sc05874b},
journal = {Chemical Science},
pages = {2604--2613},
title = {Imaging non-classical mechanical responses of lipid membranes using molecular rotors},
url = {http://dx.doi.org/10.1039/d0sc05874b},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lipid packing in cellular membranes has a direct effect on membrane tension and microviscosity, and plays a central role in cellular adaptation, homeostasis and disease. According to conventional mechanical descriptions, viscosity and tension are directly interconnected, with increased tension leading to decreased membrane microviscosity. However, the intricate molecular interactions that combine to build the structure and function of a cell membrane suggest a more complex relationship between these parameters. In this work, a viscosity-sensitive fluorophore (‘molecular rotor’) is used to map changes in microviscosity in model membranes under conditions of osmotic stress. Our results suggest that the relationship between membrane tension and microviscosity is strongly influenced by the bilayer's lipid composition. In particular, we show that the effects of increasing tension are minimised for membranes that exhibit liquid disordered (Ld) – liquid ordered (Lo) phase coexistence; while, surprisingly, membranes in pure gel and Lo phases exhibit a negative compressibility behaviour, i.e. they soften upon compression.
AU  - Paez-Perez,M
AU  - Lopez-Duarte,I
AU  - Vysniauskas,A
AU  - Brooks,NJ
AU  - Kuimova,MK
DO  - 10.1039/d0sc05874b
EP  - 2613
PY  - 2021///
SN  - 2041-6520
SP  - 2604
TI  - Imaging non-classical mechanical responses of lipid membranes using molecular rotors
T2  - Chemical Science
UR  - http://dx.doi.org/10.1039/d0sc05874b
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000621586800032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/SC/D0SC05874B#!divAbstract
UR  - http://hdl.handle.net/10044/1/87629
VL  - 12
ER  -
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