Imperial College London
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Professor Marina Kuimova

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

207BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kuimova:2017:10.1039/C7CP03571C,
author = {Kuimova, MK and Vysniauskas and Lopez, Duarte and Duchemin and Vu and Wu and Budynina and Volkova and Peña, Cabrera and Ramírez-Ornelas},
doi = {10.1039/C7CP03571C},
journal = {Physical Chemistry Chemical Physics},
pages = {25252--25259},
title = {Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors},
url = {http://dx.doi.org/10.1039/C7CP03571C},
volume = {19},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microviscosity is a key parameter controlling the rate of diffusion and reactions on the microscale. One of the most convenient tools for measuring microviscosity is by fluorescent viscosity sensors termed ‘molecular rotors’. BODIPY-based molecular rotors in particular proved extremely useful in combination with fluorescence lifetime imaging microscopy, for providing quantitative viscosity maps of living cells as well as measuring dynamic changes in viscosity over time. In this work, we investigate several new BODIPY-based molecular rotors with the aim of improving on the current viscosity sensing capabilities and understanding how the structure of the fluorophore is related to its function. We demonstrate that due to subtle structural changes, BODIPY-based molecular rotors may become sensitive to temperature and polarity of their environment, as well as to viscosity, and provide a photophysical model explaining the nature of this sensitivity. Our data suggests that a thorough understanding of the photophysics of any new molecular rotor, in environments of different viscosity, temperature and polarity, is a must before moving on to applications in viscosity sensing.
AU  - Kuimova,MK
AU  - Vysniauskas
AU  - Lopez,Duarte
AU  - Duchemin
AU  - Vu
AU  - Wu
AU  - Budynina
AU  - Volkova
AU  - Peña,Cabrera
AU  - Ramírez-Ornelas
DO  - 10.1039/C7CP03571C
EP  - 25259
PY  - 2017///
SN  - 1463-9084
SP  - 25252
TI  - Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
T2  - Physical Chemistry Chemical Physics
UR  - http://dx.doi.org/10.1039/C7CP03571C
UR  - http://hdl.handle.net/10044/1/50080
VL  - 19
ER  -
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