Summary
Professor Mara Kyrgiou is a Professor at Imperial College London and a Consultant Surgeon in Gynaecology and Gynaecological Oncology at the West London Gynaecological Cancer Centre, Imperial Healthcare NHS Trust. She is the Head of Section of Gynaecological Oncology at Imperial College London. Her main clinical interest is minimal access and complex gynaecological cancer surgery.
The primary focus of her research is traslational research in gynaecological diseases and cancers, in particular cervical, endometrial and ovarian cancer with an emphasis on prevention, early detection and personalised treatment. She runs an a programme of research investigating genetic, epigenetic, microbiome and host interaction in the aetiology of gynaecological cancers. She has an interest in cervical screening and is the Chief Investigator of the NOVEL trial on the HPV vaccination in women with cervical disease. She runs a research group investigating the impact of obesity and metabolic disorders in the development of gynaecological cancers. Her research also focuses on the role of the genital tract and gut microbiome and host interactions in the development and treatment response of gynaecological cancers.
Selected Publications
Journal Articles
Kyrgiou M, Kalliala I, Markozannes G, et al., 2017, Adiposity and cancer at all anatomic sites: an umbrella review of the literature, British Medical Journal, Vol:356, ISSN:1468-5833, Pages:1-10
Mitra A, MacIntyre D, lee YS, et al., 2015, Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity, Scientific Reports, Vol:5, ISSN:2045-2322
Theophilou G, Paraskevaidi M, Lima KMG, et al., 2015, Extracting biomarkers of commitment to cancer development: potential role of vibrational spectroscopy in systems biology, Expert Review of Molecular Diagnostics, Vol:15, ISSN:1473-7159, Pages:693-713
Papakonstantinou K, Kyrgiou M, Lyons D, et al., 2014, Management of stage Ia1 squamous cervical cancer and the importance of excision margins: a retrospective study of long-term outcome after 25 years of follow-up, American Journal of Obstetrics and Gynecology, Vol:211, ISSN:0002-9378
Kyrgiou M, Mitra A, Arbyn M, et al., 2014, Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis, British Medical Journal, Vol:349, ISSN:1468-5833, Pages:1-17
Gajjar K, Ahmadzai AA, Valasoulis G, et al., 2014, Histology verification demonstrates that biospectroscopy analysis of cervical cytology identifies underlying disease more accurately than conventional screening: Removing the confounder of discordance, PLOS One, Vol:9, ISSN:1932-6203
Woo YL, Kyrgiou M, Bryant A, et al., 2012, Centralisation of services for gynaecological cancer, Cochrane Database of Systematic Reviews, ISSN:1469-493X
Arbyn M, Kyrgiou M, Simoens C, et al., 2008, Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis, British Medical Journal, Vol:337, ISSN:1468-5833
Kyrgiou M, Salanti G, Pavlidis N, et al., 2006, Survival benefits with diverse chemotherapy regimens for ovarian cancer: Meta-analysis of multiple treatments, Journal of the National Cancer Institute, Vol:98, ISSN:0027-8874, Pages:1655-1663
Kyrgiou M, Koliopoulos G, Martin-Hirsch P, et al., 2006, Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis, The Lancet, Vol:367, ISSN:0140-6736, Pages:489-498