Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mitra:2020:10.1038/s41467-020-15856-y,
author = {Mitra, A and MacIntyre, D and Ntritsos, G and Smith, A and Tsilidis, K and Marchesi, J and Bennett, P and moscicki, A-B and Kyrgiou, M},
doi = {10.1038/s41467-020-15856-y},
journal = {Nature Communications},
pages = {1--13},
title = {The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions},
url = {http://dx.doi.org/10.1038/s41467-020-15856-y},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 adolescent and young women aged 16–26 years with histologically confirmed, untreated CIN2 lesions to determine whether VMB composition affects rates of regression over 24 months. We show that women with a Lactobacillus-dominant microbiome at baseline are more likely to have regressive disease at 12 months. Lactobacillus spp. depletion and presence of specific anaerobic taxa including Megasphaera, Prevotella timonensis and Gardnerella vaginalis are associated with CIN2 persistence and slower regression. These findings suggest that VMB composition may be a future useful biomarker in predicting disease outcome and tailoring surveillance, whilst it may offer rational targets for the development of new prevention and treatment strategies.
AU  - Mitra,A
AU  - MacIntyre,D
AU  - Ntritsos,G
AU  - Smith,A
AU  - Tsilidis,K
AU  - Marchesi,J
AU  - Bennett,P
AU  - moscicki,A-B
AU  - Kyrgiou,M
DO  - 10.1038/s41467-020-15856-y
EP  - 13
PY  - 2020///
SN  - 2041-1723
SP  - 1
TI  - The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-020-15856-y
UR  - https://www.nature.com/articles/s41467-020-15856-y
UR  - http://hdl.handle.net/10044/1/78808
VL  - 11
ER  -
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