Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paraskevaidi:2020:10.1016/j.ebiom.2020.103017,
author = {Paraskevaidi, M and Cameron, SJS and Whelan, E and Bowden, S and Tzafetas, M and Mitra, A and Semertzidou, A and Athanasiou, A and Bennett, P and MacIntyre, D and Takats, Z and Kyrgiou, M},
doi = {10.1016/j.ebiom.2020.103017},
journal = {EBioMedicine},
title = {Laser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening},
url = {http://dx.doi.org/10.1016/j.ebiom.2020.103017},
volume = {60},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but has limitations including moderate diagnostic accuracy, lack of automation, inter-observer variability and the need for clinician-collected sample. Novel, objective and cost-effective approaches are needed.MethodsIn this study, we assessed the potential use of an automated metabolomic robotic platform, employing the principle of laser-assisted Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS) in cervical cancer screening.FindingsIn a population of 130 women, LA-REIMS achieved 94% sensitivity and 83% specificity (AUC: 91.6%) in distinguishing women testing positive (n = 65) or negative (n = 65) for hrHPV. We performed further analysis according to disease severity with LA-REIMS achieving sensitivity and specificity of 91% and 73% respectively (AUC: 86.7%) in discriminating normal from high-grade pre-invasive disease.InterpretationThis automated high-throughput technology holds promise as a low-cost and rapid test for cervical cancer screening and triage. The use of platforms like LA-REIMS has the potential to further improve the accuracy and efficiency of the current national screening programme.
AU  - Paraskevaidi,M
AU  - Cameron,SJS
AU  - Whelan,E
AU  - Bowden,S
AU  - Tzafetas,M
AU  - Mitra,A
AU  - Semertzidou,A
AU  - Athanasiou,A
AU  - Bennett,P
AU  - MacIntyre,D
AU  - Takats,Z
AU  - Kyrgiou,M
DO  - 10.1016/j.ebiom.2020.103017
PY  - 2020///
SN  - 2352-3964
TI  - Laser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2020.103017
UR  - http://hdl.handle.net/10044/1/83188
VL  - 60
ER  -
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