Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pearson-Stuttard:2021:10.1158/1055-9965.EPI-20-1245,
author = {Pearson-Stuttard, J and Papadimitriou, N and Markozannes, G and Cividini, S and Kakourou, A and Gill, D and Rizos, EC and Monori, G and Ward, HA and Kyrgiou, M and Gunter, MJ and Tsilidis, KK},
doi = {10.1158/1055-9965.EPI-20-1245},
journal = {Cancer Epidemiology, Biomarkers and Prevention},
pages = {1218--1228},
title = {Type 2 diabetes and cancer: an umbrella review of observational and Mendelian randomisation studies},
url = {http://dx.doi.org/10.1158/1055-9965.EPI-20-1245},
volume = {30},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Type 2 diabetes(T2DM) has been associated with an increased risk of developing several common cancers, but it is unclear whether this association is causal. We aimed to summarise the evidence on T2DM and cancer and evaluate the validity of associations from both observational and Mendelian randomisation(MR) studies. Methods We performed an umbrella review of the evidence across meta-analyses of observational studies that examined associations of T2DM with risk of developing or dying from site-specific cancers, and MR studies that explored the potential causal association of T2DM and associated biomarkers with cancer risk. Results We identified eligible observational meta-analyses that assessed associations between T2DM and cancer incidence for 18 cancer sites, cancer mortality for seven sites, and cancer incidence or mortality for four sites. Positive associations between T2DM and six cancers reached strong or highly suggestive evidence. We found eight MR studies assessing the association of genetically predicted T2DM and seven and eight studies assessing the association of genetically predicted fasting insulin or fasting glucose concentrations, respectively, upon site-specific cancers. Positive associations were found between genetically predicted T2DM and fasting insulin and risk of six cancers. There was no association between genetically predicted fasting plasma glucose and cancer except for squamous cell lung carcinoma. Conclusions We found robust observational evidence for the association between T2DM and colorectal, hepatocellular, gallbladder, breast, endometrial and pancreatic cancer. Impact Potential causal associations were identified for genetically predicted T2DM and fasting insulin concentrations and risk of endometrial, pancreas, kidney, breast, lung and cervical cancer.
AU  - Pearson-Stuttard,J
AU  - Papadimitriou,N
AU  - Markozannes,G
AU  - Cividini,S
AU  - Kakourou,A
AU  - Gill,D
AU  - Rizos,EC
AU  - Monori,G
AU  - Ward,HA
AU  - Kyrgiou,M
AU  - Gunter,MJ
AU  - Tsilidis,KK
DO  - 10.1158/1055-9965.EPI-20-1245
EP  - 1228
PY  - 2021///
SN  - 1055-9965
SP  - 1218
TI  - Type 2 diabetes and cancer: an umbrella review of observational and Mendelian randomisation studies
T2  - Cancer Epidemiology, Biomarkers and Prevention
UR  - http://dx.doi.org/10.1158/1055-9965.EPI-20-1245
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33737302
UR  - https://cebp.aacrjournals.org/content/early/2021/03/18/1055-9965.EPI-20-1245
UR  - http://hdl.handle.net/10044/1/88356
VL  - 30
ER  -
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