Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kechagias:2022:10.1136/bmj-2022-070135,
author = {Kechagias, K and Kalliala, I and Bowden, S and Athanasiou, A and Paraskevaidi, M and Veroniki, A and Kyrgiou, M},
doi = {10.1136/bmj-2022-070135},
journal = {The BMJ},
title = {The role of HPV vaccination on HPV infection and recurrence of HPV-related disease after local surgical treatment: a systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1136/bmj-2022-070135},
volume = {378},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: The efficacy of prophylactic human papillomavirus (HPV) vaccines after surgical treatment for pre-invasive genital disease remains unclear. Our aim was to explore the efficacy of HPV vaccination on HPV infection risk and risk of recurrent HPV-related disease in individuals undergoing local surgical treatment for cervical or other HPV-related disease.Methods: Design: Systematic review and meta-analysisData sources: PubMed/Medline, Scopus, Cochrane, Web of Science and ClinicalTrials.gov were screened from inception until March 2021.Inclusion criteria: Studies reporting on HPV infection risk and recurrence of HPV-related disease after local surgical treatment of pre-invasive genital disease in vaccinated individuals. Outcome measures: Primary: Recurrence risk for cervical intraepithelial neoplasia grade 2 or higher (CIN2+)(follow-up as reported by individual studies); Secondary: risk of HPV infection, other HPV-related lesions.Data extraction and risk of bias assessment: Independent and in duplicate data extraction and quality assessment using ROBINS-I and RoB-2 tools was performed for observational studies and randomised controlled trials (RCTs). Grading of Recommendations Assessment, Development and Evaluation (GRADE) was implemented for the primary outcome.Data synthesis: Observational studies and RCTs were analysed separately from post-hoc analyses of RCTs. Pooled risk ratios (RR) and 95% confidence intervals (95% CI) were calculated using a random-effects (RE) meta-analysis model. The restricted maximum likelihood was used as an estimator for heterogeneity, and the Hartung-Knapp-Sidik-Jonkman method was used to derive confidence intervals.Results: Twenty-two articles met the inclusion criteria of the review; eighteen studies also reported data from a non-vaccinated group and were included in the meta-analyses (12 observational; 2 RCTs and 4 post-hoc analyses of RCTs). The risk of CIN2+ recurrence was reduced in vaccinated when compared to non-vaccinated
AU  - Kechagias,K
AU  - Kalliala,I
AU  - Bowden,S
AU  - Athanasiou,A
AU  - Paraskevaidi,M
AU  - Veroniki,A
AU  - Kyrgiou,M
DO  - 10.1136/bmj-2022-070135
PY  - 2022///
SN  - 0959-8138
TI  - The role of HPV vaccination on HPV infection and recurrence of HPV-related disease after local surgical treatment: a systematic review and meta-analysis.
T2  - The BMJ
UR  - http://dx.doi.org/10.1136/bmj-2022-070135
UR  - https://www.bmj.com/content/378/bmj-2022-070135
UR  - http://hdl.handle.net/10044/1/97647
VL  - 378
ER  -
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