Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nasser:2017:10.1245/s10434-017-6051-8,
author = {Nasser, S and Kyrgiou, M and Krell, J and Haidopoulos, D and Bristow, R and Fotopoulou, C},
doi = {10.1245/s10434-017-6051-8},
journal = {Annals of Surgical Oncology},
pages = {3700--3705},
title = {A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries},
url = {http://dx.doi.org/10.1245/s10434-017-6051-8},
volume = {24},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The aim of this study was to review the surgical and clinical outcomes of intrathoracic and mediastinal surgical cytoreduction in stage IV epithelial ovarian cancer (EOC). Relevant articles were identified from MEDLINE and EMBASE. Only analyses or reports that described actual intrathoracic cytoreduction via pleurectomy and/or resection of cardiophrenic/mediastinal lymph nodes were included. Imaging articles that merely described thoracic tumor patterns were excluded. A total of nine studies were identified, the oldest originating in 2007. Procedures described were transdiaphragmatic resection of cardiophrenic lymph nodes and pleural disease (n = 5) and video-assisted thoracoscopic and mediastinal tumorectomies including pleurectomy (n = 4). The number of operated patients ranged between 1 and 30 with complete cytoreduction rates ranging between 68 and 100%. No surgical deaths directly related to the thoracic cytoreduction were reported and only one patient (1/30) experienced a postoperative complication in terms of a pneumothorax. None of the studies presented a direct comparison of survival to patients with thoracic disease who did not undergo thoracic cytoreduction, and therefore the survival benefit of thoracic cytoreduction could not be quantified. In conclusion, thoracic cytoreduction in advanced EOC seems feasible and with acceptable morbidity while offering a better understanding of the extent of disease and hence allowing the tailoring of intraabdominal resections. Nevertheless, its direct impact on patients’ survival by a potential overruling of a more adverse tumor biology remains to be established in larger-scale prospective and ideally randomized trials.
AU  - Nasser,S
AU  - Kyrgiou,M
AU  - Krell,J
AU  - Haidopoulos,D
AU  - Bristow,R
AU  - Fotopoulou,C
DO  - 10.1245/s10434-017-6051-8
EP  - 3705
PY  - 2017///
SN  - 1068-9265
SP  - 3700
TI  - A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries
T2  - Annals of Surgical Oncology
UR  - http://dx.doi.org/10.1245/s10434-017-6051-8
VL  - 24
ER  -
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