Imperial College London
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Professor Maria Kyrgiou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecologic Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kyrgiou:2017:10.1002/14651858.CD012847,
author = {Kyrgiou, M and Athanasiou, A and Kalliala, IEJ and Paraskevaidi, M and Mitra, A and Martin-Hirsch, PP and Arbyn, M and Bennett, P and Paraskevaidis, E},
doi = {10.1002/14651858.CD012847},
journal = {Cochrane Database of Systematic Reviews},
title = {Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease.},
url = {http://dx.doi.org/10.1002/14651858.CD012847},
volume = {11},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The mean age of women undergoing local treatment for pre-invasive cervical disease (cervical intra-epithelial neoplasia; CIN) or early cervical cancer (stage IA1) is around their 30s and similar to the age of women having their first child. Local cervical treatment has been correlated to adverse reproductive morbidity in a subsequent pregnancy, however, published studies and meta-analyses have reached contradictory conclusions. OBJECTIVES: To assess the effect of local cervical treatment for CIN and early cervical cancer on obstetric outcomes (after 24 weeks of gestation) and to correlate these to the cone depth and comparison group used. SEARCH METHODS: We searched the following databases: Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library, 2017, Issue 5), MEDLINE (up to June week 4, 2017) and Embase (up to week 26, 2017). In an attempt to identify articles missed by the search or unpublished data, we contacted experts in the field and we handsearched the references of the retrieved articles and conference proceedings. SELECTION CRITERIA: We included all studies reporting on obstetric outcomes (more than 24 weeks of gestation) in women with or without a previous local cervical treatment for any grade of CIN or early cervical cancer (stage IA1). Treatment included both excisional and ablative methods. We excluded studies that had no untreated reference population, reported outcomes in women who had undergone treatment during pregnancy or had a high-risk treated or comparison group, or both DATA COLLECTION AND ANALYSIS: We classified studies according to the type of treatment and the obstetric endpoint. Studies were classified according to method and obstetric endpoint. Pooled risk ratios (RR) and 95% confidence intervals (CIs) were calculated using a random-effects model and inverse variance. Inter-study heterogeneity was assessed with I2 statistics. We assessed maternal outcomes that included preterm birth (PTB) (spontaneous a
AU  - Kyrgiou,M
AU  - Athanasiou,A
AU  - Kalliala,IEJ
AU  - Paraskevaidi,M
AU  - Mitra,A
AU  - Martin-Hirsch,PP
AU  - Arbyn,M
AU  - Bennett,P
AU  - Paraskevaidis,E
DO  - 10.1002/14651858.CD012847
PY  - 2017///
SN  - 1469-493X
TI  - Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease.
T2  - Cochrane Database of Systematic Reviews
UR  - http://dx.doi.org/10.1002/14651858.CD012847
UR  - http://hdl.handle.net/10044/1/54495
VL  - 11
ER  -
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