Imperial College London
Alternate

ProfessorMikeLaffan

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 2178m.laffan

 
 
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Assistant

 

Mrs Lisa Pape +44 (0)20 3313 1320

 
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Location

 

5S5bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arachchillage:2023:10.1111/bjh.18874,
author = {Arachchillage, DJ and Rajakaruna, I and Odho, Z and Makris, M and Laffan, M and CA-COVID19, Investigators},
doi = {10.1111/bjh.18874},
journal = {British Journal of Haematology},
pages = {485--497},
title = {Impact of thromboprophylaxis on hospital acquired thrombosis following discharge in patients admitted with COVID-19: multicentre observational study in the UK},
url = {http://dx.doi.org/10.1111/bjh.18874},
volume = {202},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Post-discharge thromboprophylaxis in patients admitted with COVID-19 remains controversial. We aimed to determine the impact of thromboprophylaxis on hospital acquired thrombosis (HAT) in patients (≥18 years) discharged following admission for COVID-19 in an observational study across 26 NHS Trusts in the UK (01.04.2020-31.12.2021). Overall, 8895 patients were included to the study: 971 patients were discharged with thromboprophylaxis and propensity score matched (PSM) with a desired ratio of 1:1, from patients discharged without thromboprophylaxis. Patients with heparin induced thrombocytopenia, major bleeding during admission and pregnant women were excluded. As expected from 1:1 PSM, no difference was observed in parameters between the two groups, including duration of hospital stay, except the thromboprophylaxis group had a significantly higher proportion who had received therapeutic dose anticoagulation during admission. There were no differences in the laboratory parameters especially D-dimers between the two groups at admission or discharge. Median duration of thromboprophylaxis following discharge from hospital was 4 weeks (1-8 weeks). No difference was found in HAT in patients discharged with TP versus no TP (1.3% vs. 0.92%, p = 0.52). Increasing age and smoking significantly increased the risk of HAT. Many patients in both cohorts had raised D-dimer at discharge but D-dimer was not associated with increased risk of HAT.
AU  - Arachchillage,DJ
AU  - Rajakaruna,I
AU  - Odho,Z
AU  - Makris,M
AU  - Laffan,M
AU  - CA-COVID19,Investigators
DO  - 10.1111/bjh.18874
EP  - 497
PY  - 2023///
SN  - 0007-1048
SP  - 485
TI  - Impact of thromboprophylaxis on hospital acquired thrombosis following discharge in patients admitted with COVID-19: multicentre observational study in the UK
T2  - British Journal of Haematology
UR  - http://dx.doi.org/10.1111/bjh.18874
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37202865
UR  - https://onlinelibrary.wiley.com/doi/10.1111/bjh.18874
UR  - http://hdl.handle.net/10044/1/104724
VL  - 202
ER  -
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