Imperial College London

Professor Mark Layton

Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Practice (Haematology)



+44 (0)20 3313 2173m.layton




Mrs Lisa Pape +44 (0)20 3313 1320




4N3ACommonwealth BuildingHammersmith Campus





Professor Layton joined Imperial College in 2000 as Consultant Haematologist and Honorary Reader and is Clinical Lead for Red Cell Haematology at Imperial College Healthcare NHS Trust. He is Clinical Director of the North West London Sickle Cell and Thalassaemia Network and Specialty Lead for the North West London NIHR Clinical Research Network. His clinical and research interests span the treatment and pathophysiology of red cell disorders and reflect a longstanding interest in sickle cell disease, thalassaemia and rare inherited anaemias. He is Chief/Principal investigator on several early and pivotal clinical trials of novel disease modifiers that include a first-in-class allosteric activator of red cell pyruvate kinase. He was project lead for haemolytic anaemia on the NIHR Rare Disease Translational Research Collaboration and as co-chair of the red cell multidisciplinary team (MDT) supports the NIHR BioResource Rare Disease programme. His external activities have included UK NEQAS Special Scientific Advisory Group, Medical Research Council, UK Forum on Haemoglobin Disorders, National Confidential Enquiry into Counselling for Genetic Disorders, Royal College of Obstetricians and Gynaecologists, British Paediatric Survellance Unit and British Society for Haematology steering group or committee membership. He is Medical Advisor to the Sickle Cell Society.



Adissu W, Brito M, Garbin E, et al., 2023, Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis., Plos Negl Trop Dis, Vol:17

Bain BJ, Hann A, Layton DM, 2023, Putting unstable hemoglobins on the map of London, American Journal of Hematology, Vol:98, ISSN:0361-8609, Pages:1488-1489

Hinton R, Haji R, Kaczmarski R, et al., 2023, Hyperhaemolysis caused by anti-HI antibodies in a patient with myelodysplastic syndrome following a first ever red cell transfusion, Transfusion Medicine, Vol:33, ISSN:0958-7578, Pages:349-351

Clayden JD, Stotesbury H, Kawadler JM, et al., 2023, Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia, Blood Advances, Vol:7, ISSN:2473-9529, Pages:2297-2308

Al-Samkari H, Grace RF, Glenthoj A, et al., 2023, Early-onset reduced bone mineral density in patients with pyruvate kinase deficiency, American Journal of Hematology, Vol:98, ISSN:0361-8609, Pages:E57-E60

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