Imperial College London

Professor Mark Layton

Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Practice (Haematology)
 
 
 
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Contact

 

+44 (0)20 3313 2173m.layton

 
 
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Assistant

 

Mrs Lisa Pape +44 (0)20 3313 1320

 
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Location

 

4N3ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

179 results found

Bain BJ, Myburgh J, Hann A, Layton DMet al., 2022, Voxelotor in sickle cell disease, American Journal of Hematology, Vol: 97, Pages: 830-832, ISSN: 0361-8609

Journal article

Collington SJ, Nawaz A, Walder S, Prashar S, Houston S, Cohen C, Layton DMet al., 2022, Retrospective analysis of the burden of vaso-occlusive events experienced by sickle cell disease (SCD) patients in the integrated health and social care system in North West London, Publisher: WILEY, Pages: 130-131, ISSN: 0007-1048

Conference paper

Dexter D, Layton DM, Kiritkumar K, Bain BJet al., 2022, Peripheral blood features of iron overload in post-splenectomy, type I congenital dyserythropoietic anemia, American Journal of Hematology, Vol: 97, Pages: 237-238, ISSN: 0361-8609

Journal article

Stotesbury H, Hales PW, Koelbel M, Hood AM, Kawadler JM, Saunders DE, Sahota S, Rees DC, Wilkey O, Layton M, Pelidis M, Inusa BPD, Howard J, Chakravorty S, Clark CA, Kirkham FJet al., 2022, Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 42, Pages: 1061-1077, ISSN: 0271-678X

Journal article

Hui YMT, Gurung K, Layton DM, Ibidapo M, Grimsley S, Regan Fet al., 2021, Sickle cell disease patients in two London trusts: Genotyping including RH variants, TRANSFUSION MEDICINE, Vol: 32, Pages: 210-220, ISSN: 0958-7578

Journal article

Bianchi P, van Beers EJ, Vives Corrons J-L, Glader B, Glenthoj A, Kanno H, Kuo KHM, Lander C, Layton DM, Pospisilova D, Viprakasit V, Williams J, Yan Y, Mcgee B, Grace RFet al., 2021, BASELINE CHARACTERISTICS BY AGE OF A GLOBAL COHORT OF PATIENTS DIAGNOSED WITH PYRUVATE KINASE DEFICIENCY - A DESCRIPTIVE ANALYSIS FROM THE PEAK REGISTRY, Publisher: FERRATA STORTI FOUNDATION, Pages: 107-108, ISSN: 0390-6078

Conference paper

Al-Samkari H, Grace RF, Glenthoj A, Andres O, Barcellini W, Galacteros F, Kuo KHM, Layton DM, Morado Arias M, Viprakasit V, Dong Y, Tai F, Hawkins P, Gheuens S, Bowden C, Porter J, van Beers EJet al., 2021, EARLY-ONSET OSTEOPENIA AND OSTEOPOROSIS IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY, Publisher: FERRATA STORTI FOUNDATION, Pages: 108-108, ISSN: 0390-6078

Conference paper

Al-Samkari H, Galacteros F, Glenthoj A, Rothman JA, Andres O, Grace RF, Morado Arias M, Layton DM, Onodera K, Verhovsek M, Barcellini W, Judge MP, Beynon V, Xu E, Hawkins P, Zagadailov E, Gheuens S, van Beers EJet al., 2021, ACTIVATE: A PHASE 3, RANDOMIZED, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MITAPIVAT IN ADULTS WITH PYRUVATE KINASE DEFICIENCY WHO ARE NOT REGULARLY TRANSFUSED, Publisher: FERRATA STORTI FOUNDATION, Pages: 106-106, ISSN: 0390-6078

Conference paper

Cappellini M, Kuo KHM, Layton DM, Al-Samkari H, Kattamis A, Sheth S, Taher A, Viprakasit V, Chamberlain C, Czapla L, Gheuens S, Jiang L, Lynch M, Tong B, Uhlig Ket al., 2021, ENERGIZE AND ENERGIZE-T: TWO PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES OF MITAPIVAT IN ADULTS WITH NON-TRANSFUSION-DEPENDENT OR TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA, Publisher: FERRATA STORTI FOUNDATION, Pages: 110-111, ISSN: 0390-6078

Conference paper

Pal S, Myburgh J, Bansil P, Hann A, Robertson L, Gerth-Guyette E, Ambler G, Bizilj G, Kahn M, Zobrist S, Manis MR, Styke NA, Allan V, Ansbro R, Akingbade T, Bryan A, Murphy SC, Kublin JG, Layton M, Domingo GJet al., 2021, Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision, PLOS ONE, Vol: 16, ISSN: 1932-6203

Journal article

Al-Samkari H, Grace RF, Glenthoj A, Andres O, Barcellini W, Galacteros F, Kuo KHM, Layton DM, Arias MM, Viprakasit V, Dong Y, Tai F, Hawkins P, Gheuens S, Bowden C, Porter J, van Beers EJet al., 2021, Early-Onset osteopenia and osteoporosis in patients with pyruvate kinase deficiency, Publisher: KARGER, Pages: 170-170, ISSN: 2296-5270

Conference paper

Al-Samkari H, Galacteros F, Glenthoj A, Rothman JA, Andres O, Grace RF, Arias MM, Layton DM, Onodera K, Verhovsek M, Barcellini W, Judge MP, Beynon V, Xu E, Hawkins P, Zagadailov E, Gheuens S, van Beers EJet al., 2021, ACTIVATE: A phase 3, randomized, multicenter, double-blind, placebo-controlled study of mitapivat in adults with Pyruvate kinase deficiency who are not regularly transfused, Publisher: KARGER, Pages: 40-40, ISSN: 2296-5270

Conference paper

Grace RF, Boscoe A, Bowden C, Glader B, Kanno H, Layton DM, Van Beers E, Corrons J-LV, Yan Y, Bianchi Pet al., 2020, Baseline Characteristics of Patients in Peak: A Global, Longitudinal Registry of Patients with Pyruvate Kinase Deficiency, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Al-Samkari H, Grace RF, Glenthoej A, Andres O, Barcellini W, Galacteros F, Kuo KHM, Layton DM, Morado M, Viprakasit V, Dong Y, Tai F, Hawkins P, Gheuens S, Bowden C, Porter JB, Van Beers Eet al., 2020, Early-Onset Osteopenia and Osteoporosis in Patients with Pyruvate Kinase Deficiency, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Layton D, Piel F, Telfer P, 2020, Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients, Haematologica: the hematology journal, Vol: 105, Pages: 2651-2654, ISSN: 0390-6078

Journal article

Roy NBA, Telfer P, Eleftheriou P, de la Fuente J, Drasar E, Shah F, Roberts D, Atoyebi W, Trompeter S, Layton DM, Lugthart S, Stuart-Smith S, Chakravorty S, Wright J, Porter J, Inusa B, Howard Jet al., 2020, Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic, British Journal of Haematology, Vol: 189, Pages: 635-639, ISSN: 0007-1048

With the developing COVID‐19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. The National Haemoglobinopathy Panel (NHP) has issued guidance on the care of patients with sickle cell disease, thalassaemia, Diamond Blackfan anaemia (DBA), congenital dyserythropoietic anaemia (CDA), sideroblastic anaemia, pyruvate kinase deficiency and other red cell enzyme and membrane disorders. Cascading of accurate information for clinicians and patients is paramount to preventing adverse outcomes, such as patients who are at increased risk of fulminant bacterial infection due to their condition or its treatment erroneously self‐isolating if their fever is mistakenly attributed to a viral cause, delaying potentially life‐saving antibiotic therapy. Outpatient visits should be minimised for most patients, however some, such as first transcranial dopplers for children with sickle cell anaemia should not be delayed as known risk of stroke will outweigh the unknown risk from COVID‐19 infection. Blood transfusion programmes should be continued, but specific changes to usual clinical pathways can be instituted to reduce risk of patient exposure to COVID‐19, as well as contingency planning for possible reductions in blood available for transfusions. Bone marrow transplants for these disorders should be postponed until further notice. With the current lack of evidence on the risk and complications of COVID‐19 infection in these patients, national data collection is ongoing to record outcomes and eventually to identify predictors of disease severity, particularly important if further waves of infection travel through the population.

Journal article

Hui YMT, Gurung K, Mkandawire C, Kiilu P, Lund K, Ibidapo M, Layton DM, Regan Fet al., 2020, Audit of red cell genotyping in sickle cell disease patients in two London trusts, 60th Annual Scientific Meeting of the British-Society-for-Haematology (BSH), Publisher: WILEY, Pages: 175-175, ISSN: 0007-1048

Conference paper

Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N, Wang J, Tummala H, Al Seraihi AFH, Alnajar J, Bewicke-Copley F, Armes H, Barnett M, Bloor A, Bodor C, Bowen D, Fenaux P, Green A, Hallahan A, Hjorth-Hansen H, Hossain U, Killick S, Lawson S, Layton M, Male AM, Marsh J, Mehta P, Mous R, Nomdedeu JF, Owen C, Pavlu J, Payne EM, Protheroe RE, Preudhomme C, Pujol-Moix N, Renneville A, Russell N, Saggar A, Sciuccati G, Taussig D, Toze CL, Uyttebroeck A, Vandenberghe P, Schlegelberger B, Ripperger T, Steinemann D, Wu J, Mason J, Page P, Akiki S, Reay K, Cavenagh JD, Plagnol V, Caceres JF, Fitzgibbon J, Dokal Iet al., 2020, The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants, Nature Communications, Vol: 11, Pages: 1-12, ISSN: 2041-1723

The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we report a cohort of 86 acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) families with 49 harboring germline variants in 16 previously defined loci (57%). Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize 65 new candidate loci, including genes mutated in rare hematological syndromes (ADA, GP6, IL17RA, PRF1 and SEC23B), reported in prior MDS/AML or inherited bone marrow failure series (DNAH9, NAPRT1 and SH2B3) or variants at novel loci (DHX34) that appear specific to inherited forms of myeloid malignancies. Altogether, our series of MDS/AML families offer novel insights into the etiology of myeloid malignancies and provide a framework to prioritize variants for inclusion into routine diagnostics and patient management.

Journal article

Roper D, Layton M, Rees D, Lambert C, Vulliamy T, De la Salle B, D'Souza Cet al., 2020, Laboratory diagnosis of G6PD deficiency. A British Society for Haematology Guideline, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 189, Pages: 24-38, ISSN: 0007-1048

Journal article

Grace RF, Bianchi P, Glader B, Glenthoj A, Jones B, Kanno H, Kuo KHM, Layton DM, van Beers EJ, Corrons J-LV, Xu Tet al., 2019, An Ongoing Global, Longitudinal, Observational Study of Patients with Pyruvate Kinase Deficiency: The PEAK Registry, 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Kuo KHM, Layton DM, Uhlig K, Lynch M, Liu L, Vichinsky EPet al., 2019, Mitapivat (AG-348), an Oral PK-R Activator, in Adults with Non-Transfusion Dependent Thalassemia: A Phase 2, Open-Label, Multicenter Study in Progress, 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Grace RF, Layton DM, Galacteros F, Barcellini W, van Beers EJ, Yaish HM, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Hua L, Hawkins PF, Mix C, Glader Bet al., 2019, Long-Term Safety and Efficacy of Mitapivat (AG-348), a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency: The DRIVE PK Study, 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Grace RF, Rose C, Layton DM, Galacteros F, Barcellini W, Morton DH, van Beers EJ, Yaish H, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Barbier AJ, Bodie S, Silver B, Hua L, Kung C, Hawkins P, Jouvin M-H, Bowden C, Glader Bet al., 2019, Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 381, Pages: 933-944, ISSN: 0028-4793

Journal article

Shabbir S, Al-Abdulla A, Kinderlerer A, Sohal M, Layton M, Hill P, Corbett R, Lightstone L, Cairns T, Mason J, Cooper N, Youngstein Tet al., 2019, OFF-LICENCE USE OF ANAKINRA IN CRITICALLY ILL ADULTS WITH SUSPECTED HAEMOPHAGOCYTOSIS - A SINGLE CENTRE EXPERIENCE, Annual European Congress of Rheumatology (EULAR), Publisher: BMJ PUBLISHING GROUP, Pages: 292-293, ISSN: 0003-4967

Conference paper

Bianchi P, Glader B, Grace R, Kanno H, Layton DM, van Beers E, Corrons J-L, Hua L, Jones Bet al., 2019, PEAK REGISTRY: A GLOBAL LONGITUDINAL OBSERVATIONAL STUDY OF PATIENTS WITH PYRUVATE KINASE DEFICIENCY, Publisher: WILEY, ISSN: 1545-5009

Conference paper

Grace RF, Layton DM, Barcellini W, 2019, How we manage patients with pyruvate kinase deficiency (vol 184, pg 721, 2019), BRITISH JOURNAL OF HAEMATOLOGY, Vol: 185, Pages: 807-807, ISSN: 0007-1048

Journal article

Howard J, Hemmaway CJ, Telfer P, Layton DM, Porter J, Awogbade M, Mant T, Gretler DD, Dufu K, Hutchaleelaha A, Patel M, Siu V, Dixon S, Landsman N, Tonda M, Lehrer-Graiwer Jet al., 2019, A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease, BLOOD, Vol: 133, Pages: 1865-1875, ISSN: 0006-4971

Journal article

Hutchinson M, Sohal M, Layton M, Sriskandan S, Brett S, Hill P, Youngstein TABet al., 2019, STEROID-FREE MANAGEMENT OF LIFE-THREATENING HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN THE CONTEXT OF SUSPECTED LYMPHOPROLIFERATIVE DISEASE AND INFECTION, Annual Conference of the British-Soceity-for-Rheumatology, Publisher: OXFORD UNIV PRESS, ISSN: 1462-0324

Conference paper

Thielemans L, Layton DM, Shovlin CL, 2019, Low serum haptoglobin and blood films suggest intravascular haemolysis contributes to severe anaemia in hereditary haemorrhagic telangiectasia, Haematologica, Vol: 104, Pages: e127-e130, ISSN: 0390-6078

Journal article

Brierley C, Babbs C, McGowan S, Downes D, Sanchis-Juan A, Aydinok Y, Thakur I, Connor P, Tedgard U, Bechensteen AG, Harvet G, de la Fuente J, Mettananda S, Hendricks M, Carey P, Lausen B, Ancliff P, Qureshi A, Louka E, Okoli S, Psaila B, O'Sullivan J, Mead A, Mapeta R, Megy K, Ouwehand W, Turro E, Roberts I, Layton M, Roy Net al., 2019, Whole genome sequencing for the investigation of rare anaemias: Challenges and real-world outcomes, 59th Annual Scientific Meeting of the British-Society-for-Hematology, Publisher: WILEY, Pages: 115-116, ISSN: 0007-1048

Conference paper

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