Imperial College London

Professor Mark Layton

Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Practice (Haematology)
 
 
 
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Contact

 

+44 (0)20 3313 2173m.layton

 
 
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Assistant

 

Mrs Lisa Pape +44 (0)20 3313 1320

 
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Location

 

4N3ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

162 results found

Layton D, Piel F, Telfer P, 2020, Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients, Haematologica: the hematology journal, Vol: 105, Pages: 2651-2654, ISSN: 0390-6078

Journal article

Roy NBA, Telfer P, Eleftheriou P, de la Fuente J, Drasar E, Shah F, Roberts D, Atoyebi W, Trompeter S, Layton DM, Lugthart S, Stuart-Smith S, Chakravorty S, Wright J, Porter J, Inusa B, Howard Jet al., 2020, Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic, British Journal of Haematology, Vol: 189, Pages: 635-639, ISSN: 0007-1048

With the developing COVID‐19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. The National Haemoglobinopathy Panel (NHP) has issued guidance on the care of patients with sickle cell disease, thalassaemia, Diamond Blackfan anaemia (DBA), congenital dyserythropoietic anaemia (CDA), sideroblastic anaemia, pyruvate kinase deficiency and other red cell enzyme and membrane disorders. Cascading of accurate information for clinicians and patients is paramount to preventing adverse outcomes, such as patients who are at increased risk of fulminant bacterial infection due to their condition or its treatment erroneously self‐isolating if their fever is mistakenly attributed to a viral cause, delaying potentially life‐saving antibiotic therapy. Outpatient visits should be minimised for most patients, however some, such as first transcranial dopplers for children with sickle cell anaemia should not be delayed as known risk of stroke will outweigh the unknown risk from COVID‐19 infection. Blood transfusion programmes should be continued, but specific changes to usual clinical pathways can be instituted to reduce risk of patient exposure to COVID‐19, as well as contingency planning for possible reductions in blood available for transfusions. Bone marrow transplants for these disorders should be postponed until further notice. With the current lack of evidence on the risk and complications of COVID‐19 infection in these patients, national data collection is ongoing to record outcomes and eventually to identify predictors of disease severity, particularly important if further waves of infection travel through the population.

Journal article

Hui YMT, Gurung K, Mkandawire C, Kiilu P, Lund K, Ibidapo M, Layton DM, Regan Fet al., 2020, Audit of red cell genotyping in sickle cell disease patients in two London trusts, 60th Annual Scientific Meeting of the British-Society-for-Haematology (BSH), Publisher: WILEY, Pages: 175-175, ISSN: 0007-1048

Conference paper

Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N, Wang J, Tummala H, Al Seraihi AFH, Alnajar J, Bewicke-Copley F, Armes H, Barnett M, Bloor A, Bodor C, Bowen D, Fenaux P, Green A, Hallahan A, Hjorth-Hansen H, Hossain U, Killick S, Lawson S, Layton M, Male AM, Marsh J, Mehta P, Mous R, Nomdedeu JF, Owen C, Pavlu J, Payne EM, Protheroe RE, Preudhomme C, Pujol-Moix N, Renneville A, Russell N, Saggar A, Sciuccati G, Taussig D, Toze CL, Uyttebroeck A, Vandenberghe P, Schlegelberger B, Ripperger T, Steinemann D, Wu J, Mason J, Page P, Akiki S, Reay K, Cavenagh JD, Plagnol V, Caceres JF, Fitzgibbon J, Dokal Iet al., 2020, The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants, Nature Communications, Vol: 11, Pages: 1-12, ISSN: 2041-1723

The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we report a cohort of 86 acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) families with 49 harboring germline variants in 16 previously defined loci (57%). Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize 65 new candidate loci, including genes mutated in rare hematological syndromes (ADA, GP6, IL17RA, PRF1 and SEC23B), reported in prior MDS/AML or inherited bone marrow failure series (DNAH9, NAPRT1 and SH2B3) or variants at novel loci (DHX34) that appear specific to inherited forms of myeloid malignancies. Altogether, our series of MDS/AML families offer novel insights into the etiology of myeloid malignancies and provide a framework to prioritize variants for inclusion into routine diagnostics and patient management.

Journal article

Roper D, Layton M, Rees D, Lambert C, Vulliamy T, De la Salle B, D'Souza Cet al., 2020, Laboratory diagnosis of G6PD deficiency. A British Society for Haematology Guideline, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 189, Pages: 24-38, ISSN: 0007-1048

Journal article

Grace RF, Rose C, Layton DM, Galacteros F, Barcellini W, Morton DH, van Beers EJ, Yaish H, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Barbier AJ, Bodie S, Silver B, Hua L, Kung C, Hawkins P, Jouvin M-H, Bowden C, Glader Bet al., 2019, Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 381, Pages: 933-944, ISSN: 0028-4793

Journal article

Bianchi P, Glader B, Grace R, Kanno H, Layton DM, van Beers E, Corrons J-L, Hua L, Jones Bet al., 2019, PEAK REGISTRY: A GLOBAL LONGITUDINAL OBSERVATIONAL STUDY OF PATIENTS WITH PYRUVATE KINASE DEFICIENCY, Publisher: WILEY, ISSN: 1545-5009

Conference paper

Shabbir S, Al-Abdulla A, Kinderlerer A, Sohal M, Layton M, Hill P, Corbett R, Lightstone L, Cairns T, Mason J, Cooper N, Youngstein Tet al., 2019, OFF-LICENCE USE OF ANAKINRA IN CRITICALLY ILL ADULTS WITH SUSPECTED HAEMOPHAGOCYTOSIS - A SINGLE CENTRE EXPERIENCE, Annual European Congress of Rheumatology (EULAR), Publisher: BMJ PUBLISHING GROUP, Pages: 292-293, ISSN: 0003-4967

Conference paper

Grace RF, Layton DM, Barcellini W, 2019, How we manage patients with pyruvate kinase deficiency (vol 184, pg 721, 2019), BRITISH JOURNAL OF HAEMATOLOGY, Vol: 185, Pages: 807-807, ISSN: 0007-1048

Journal article

Howard J, Hemmaway CJ, Telfer P, Layton DM, Porter J, Awogbade M, Mant T, Gretler DD, Dufu K, Hutchaleelaha A, Patel M, Siu V, Dixon S, Landsman N, Tonda M, Lehrer-Graiwer Jet al., 2019, A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease, BLOOD, Vol: 133, Pages: 1865-1875, ISSN: 0006-4971

Journal article

Hutchinson M, Sohal M, Layton M, Sriskandan S, Brett S, Hill P, Youngstein TABet al., 2019, STEROID-FREE MANAGEMENT OF LIFE-THREATENING HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN THE CONTEXT OF SUSPECTED LYMPHOPROLIFERATIVE DISEASE AND INFECTION, Annual Conference of the British-Soceity-for-Rheumatology, Publisher: OXFORD UNIV PRESS, ISSN: 1462-0324

Conference paper

Thielemans L, Layton DM, Shovlin CL, 2019, Low serum haptoglobin and blood films suggest intravascular haemolysis contributes to severe anaemia in hereditary haemorrhagic telangiectasia, Haematologica, Vol: 104, Pages: e127-e130, ISSN: 0390-6078

Journal article

Brierley C, Babbs C, McGowan S, Downes D, Sanchis-Juan A, Aydinok Y, Thakur I, Connor P, Tedgard U, Bechensteen AG, Harvet G, de la Fuente J, Mettananda S, Hendricks M, Carey P, Lausen B, Ancliff P, Qureshi A, Louka E, Okoli S, Psaila B, O'Sullivan J, Mead A, Mapeta R, Megy K, Ouwehand W, Turro E, Roberts I, Layton M, Roy Net al., 2019, Whole genome sequencing for the investigation of rare anaemias: Challenges and real-world outcomes, 59th Annual Scientific Meeting of the British-Society-for-Hematology, Publisher: WILEY, Pages: 115-116, ISSN: 0007-1048

Conference paper

Grace RF, Layton DM, Barcellini W, 2019, How we manage patients with pyruvate kinase deficiency, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 184, Pages: 721-734, ISSN: 0007-1048

Journal article

Vora SM, Proven M, Hipkiss R, Ware P, Howard K, Dreau H, Baird S, Ouwehand W, Megy K, Stirrups K, Lim D, Norton A, Kumar A, Roberts I, Layton M, Roy Net al., 2019, Glucophosphate isomerase deficiency identified by next-generation sequencing, 59th Annual Scientific Meeting of the British-Society-for-Hematology, Publisher: WILEY, Pages: 118-118, ISSN: 0007-1048

Conference paper

Thielemans L, Layton M, Shovlin CL, 2018, EVIDENCE OF HAEMOLYSIS IN PATIENTS WITH PULMONARY AVMS AND HEREDITARY HAEMORRHAGIC TELANGIECTASIA, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A102-A103, ISSN: 0040-6376

Conference paper

Lucchini E, Luqmani A, Atta M, Deplano S, Layton M, Vladescu C, Paul D, Kousios A, Charif R, Cooper Net al., 2018, Autoimmune Cytopenias Following Alemtuzumab-Induced Renal Transplant: Clinical Features and Treatment Outcomes, 60th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Farmery JHR, Smith ML, Lynch AG, Huissoon A, Furnell A, Mead A, Levine AP, Manzur A, Thrasher A, Greenhalgh A, Parker A, Sanchis-Juan A, Richter A, Gardham A, Lawrie A, Sohal A, Creaser-Myers A, Frary A, Greinacher A, Themistocleous A, Peacock AJ, Marshall A, Mumford A, Rice A, Webster A, Brady A, Koziell A, Manson A, Chandra A, Hensiek A, in't Veld AH, Maw A, Kelly AM, Moore A, Noordegraaf AV, Attwood A, Herwadkar A, Ghofrani A, Houweling AC, Girerd B, Furie B, Treacy CM, Millar CM, Sewell C, Roughley C, Titterton C, Williamson C, Hadinnapola C, Deshpande C, Toh C-H, Bacchelli C, Patch C, Van Geet C, Babbs C, Bryson C, Penkett CJ, Rhodes CJ, Watt C, Bethune C, Booth C, Lentaigne C, McJannet C, Church C, French C, Samarghitean C, Halmagyi C, Gale D, Greene D, Hart D, Allsup D, Bennett D, Edgar D, Kiely DG, Gosal D, Perry DJ, Keeling D, Montani D, Shipley D, Whitehorn D, Fletcher D, Krishnakumar D, Grozeva D, Kumararatne D, Thompson D, Josifova D, Maher E, Wong EKS, Murphy E, Dewhurst E, Louka E, Rosser E, Chalmers E, Colby E, Drewe E, McDermott E, Thomas E, Staples E, Clement E, Matthews E, Wakeling E, Oksenhendler E, Turro E, Reid E, Wassmer E, Raymond FL, Hu F, Kennedy F, Soubrier F, Flinter F, Kovacs G, Polwarth G, Ambegaonkar G, Arno G, Hudson G, Woods G, Coghlan G, Hayman G, Arumugakani G, Schotte G, Cook HT, Alachkar H, Allen HL, Lango-Allen H, Stark H, Stauss H, Schulze H, Boggard HJ, Baxendale H, Dolling H, Firth H, Gall H, Watson H, Longhurst H, Markus HS, Watkins H, Simeoni I, Emmerson I, Roberts I, Quinti I, Wanjiku I, Gibbs JSR, Thaventhiran J, Whitworth J, Hurst J, Collins J, Suntharalingam J, Payne J, Thachil J, Martin JM, Martin J, Carmichael J, Maimaris J, Paterson J, Pepke-Zaba J, Heemskerk JWM, Gebhart J, Davis J, Pasi J, Bradley JR, Wharton J, Stephens J, Rankin J, Anderson J, Vogt J, von Ziegenweldt J, Rehnstrom K, Megy K, Talks K, Peerlinck K, Yates K, Freson K, Stirrups K, Gomez K, Smith KGC, Carss K, Rue-Albrecht K, Gilmour K, Masati L, Scelsiet al., 2018, Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data, Scientific Reports, Vol: 8, ISSN: 2045-2322

Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-14403-y, published online 22 January 2018The original version of this Article contained a typographical error in the spelling of the consortium member Patrick Yu-Wai-Man which was incorrectly given as Patrick Yu Wai Man.In addition, a supplementary file containing additional algorithms and analysis was omitted from the original version of this Article.These errors have now been corrected in the HTML and PDF versions of the Article.

Journal article

Griffin M, Neilly I, Nikolousis M, Narayanan S, Lowndes K, Koh M, Ros J, Ingram W, Couzens S, Karim R, Morgan L, McMullin M, Sharma N, Mitchell L, Layton M, Medd P, Chattree S, Hill Aet al., 2018, Lessons learned from a review of paroxysmal nocturnal haemoglobinuria (PNH) requests: a report from the UK PNH Network, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 182, Pages: 930-933, ISSN: 0007-1048

Journal article

Hanina S, Bain BJ, Clark B, Layton DMet al., 2018, Congenital sideroblastic anemia in a female, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 93, Pages: 1181-1182, ISSN: 0361-8609

Journal article

Spencer-Chapman M, Luqmani A, Layton DM, Bain BJet al., 2018, Unusual inclusions in hemoglobin H disease post-splenectomy, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 93, Pages: 963-964, ISSN: 0361-8609

Journal article

Stotesbury H, Kirkham FJ, Kolbel M, Balfour P, Clayden JD, Sahota S, Sakaria S, Saunders DE, Howard J, Kesse-Adu R, Inusa B, Pelidis M, Chakravorty S, Rees DC, Awogbade M, Wilkey O, Layton M, Clark CA, Kawadler JMet al., 2018, White matter integrity and processing speed in sickle cell anemia, NEUROLOGY, Vol: 90, Pages: E2042-E2050, ISSN: 0028-3878

Journal article

Deplano S, Atta M, Luqmani A, Vladescu C, Paul D, Layton M, Cooper Net al., 2018, Immune thrombocytopenia in the elderly: a single centre experience., 58th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY, Pages: 51-51, ISSN: 0007-1048

Conference paper

Grace RF, Layton DM, Galacteros F, Rose C, Barcellini W, Morton DH, Van Beers EJ, Yaish HM, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Silver B, Kung C, Cohen M, Yang H, Kosinski PA, Hua L, Barbier A, Glader Bet al., 2017, Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency, 59th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Shovlin CL, Boother EJ, Fung CH, Bamford KB, Layton DM, Jackson JE, Brownlow Set al., 2017, PULMONARY ARTERIOVENOUS MALFORMATIONS, HEREDITARY HAEMORRHAGIC TELANGIECTASIA AND IRON TREATMENTS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A180-A180, ISSN: 0040-6376

Conference paper

Grace RF, Layton DM, Galacteros F, Rose C, Barcellini W, Morton DH, van Beers E, Yaish H, Ravindranath Y, Kuo K, Sheth S, Kwiatkowski JL, Silver B, Kung C, Cohen M, Yang H, Kosinski PA, Hua L, Barbier A, Glader Bet al., 2017, EFFECTS OF AG-348, A PYRUVATE KINASE ACTIVATOR, IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY: UPDATED RESULTS FROM THE DRIVE PK STUDY, 22nd Congress of the European-Hematology-Association, Publisher: FERRATA STORTI FOUNDATION, Pages: 164-164, ISSN: 0390-6078

Conference paper

Morris A, Bain BJ, Atta M, Layton DMet al., 2017, A puzzling case of methemoglobinemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 92, Pages: 1103-1104, ISSN: 0361-8609

Journal article

Lehrer-Graiwer J, Howard J, Hemmaway CJ, Awogbade M, Telfer P, Layton M, Porter JB, Mant T, Dufu K, Hutchaleelaha A, Oksenberg D, Patel M, Tonda ME, Bridges K, Ramos Eet al., 2016, Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Grace RF, Rose C, Layton DM, Yaish HM, Barcellini W, Galacteros F, Morton DH, Ravindranath Y, Kuo KHM, van Beers EJ, Kwiatkowski JL, Silver BA, Merica E, Kung C, Cohen M, Yang H, Hixon J, Kosinski PA, Silverman L, Dang L, Yuan ZJ, Barbier AJ, Glader Bet al., 2016, Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Shovlin CL, Hughes JMB, Layton M, Boother E, Allison DJ, Jackson JEet al., 2016, LONG TERM OUTCOMES FOR PATIENTS WITH PULMONARY ARTERIOVENOUS MALFORMATIONS CONSIDERED FOR LUNG TRANSPLANTATION, British Thoracic Society Winter Meeting 2016, Publisher: BMJ PUBLISHING GROUP, Pages: A101-A101, ISSN: 0040-6376

Conference paper

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