Imperial College London
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ProfessorMaudLemoine

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor and Honorary Consultant in Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 5212m.lemoine

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cohen:2020:10.1016/j.jhepr.2020.100144,
author = {Cohen, D and Ghosh, S and Shimakawa, Y and Ramou, N and Garcia, PS and Dubois, A and Guillot, C and Deluce, NK-N and Tilloy, V and Durand, G and Voegele, C and Ndow, G and D'Alessandro, U and Brochier-Armanet, C and Alain, S and Le, Calvez-Kelm F and Hall, J and Zoulim, F and Mendy, M and Thursz, M and Lemoine, M and Chemin, I},
doi = {10.1016/j.jhepr.2020.100144},
journal = {JHEP Reports},
title = {Hepatitis B virus preS2 Delta 38-55 variants: A newly identified risk factor for hepatocellular carcinoma},
url = {http://dx.doi.org/10.1016/j.jhepr.2020.100144},
volume = {2},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & AimsAlthough HBV is a major cause of death in Africa, its genetic variability has been poorly documented. This study aimed to address whether HBV genotype and surface gene variants are associated with HBV-related liver disease in The Gambia.MethodsWe conducted a case-control study nested in the Prevention of Liver Fibrosis and Cancer in Africa programme. Consecutive treatment-naive patients with chronic HBV infection and detectable viral load were recruited: 211 controls with no significant liver disease and 91 cases (56 cirrhosis and 35 HCC cases). HBV genotypes and surface gene variants were determined by Sanger sequencing or next-generation sequencing (NGS) in serum DNA. Aflatoxin B1 (AFB1)-specific codon 249 TP53 mutation was determined by NGS in circulating cell-free plasma DNA.ResultsIn phylogenetic analysis, 85% of individuals carried HBV genotype E, 14% genotype A, and 1% A/E recombinant viruses. Surface gene variants were more frequently observed in cases (43% and 57% in cirrhosis and HCC cases, respectively) than controls (25%; p <0.001), with preS2 deletions between nucleotides 38–55 (preS2Δ38–55) being the main genetic variant detected. In multivariable analysis, HBeAg seropositivity, low HBsAg levels, and HDV seropositivity were significantly associated with cirrhosis and HCC, whilst older age, higher viral load, genotype A, preS2Δ38–55, and AFB1 exposure were only associated with HCC. There was a multiplicative joint effect of preS2Δ38–55 variants with HBeAg seropositivity (odds ratio [OR] 43.1 [10.4–177.7]), high viral load >2,000 IU/ml (OR 22.7 [8.0–64.9]), HBsAg levels <10,000 IU/ml (OR 19.0 [5.5–65.3]), and AFB1 exposure (OR 29.3 [3.7–230.4]) on HCC risk.ConclusionsThis study identified a hotspot for HBV preS2 deletions as a strong independent factor for HCC in The Gambia, with HBV genotypes and AFB1 exposure contributing to the high liver cancer risk.
AU  - Cohen,D
AU  - Ghosh,S
AU  - Shimakawa,Y
AU  - Ramou,N
AU  - Garcia,PS
AU  - Dubois,A
AU  - Guillot,C
AU  - Deluce,NK-N
AU  - Tilloy,V
AU  - Durand,G
AU  - Voegele,C
AU  - Ndow,G
AU  - D'Alessandro,U
AU  - Brochier-Armanet,C
AU  - Alain,S
AU  - Le,Calvez-Kelm F
AU  - Hall,J
AU  - Zoulim,F
AU  - Mendy,M
AU  - Thursz,M
AU  - Lemoine,M
AU  - Chemin,I
DO  - 10.1016/j.jhepr.2020.100144
PY  - 2020///
SN  - 2589-5559
TI  - Hepatitis B virus preS2 Delta 38-55 variants: A newly identified risk factor for hepatocellular carcinoma
T2  - JHEP Reports
UR  - http://dx.doi.org/10.1016/j.jhepr.2020.100144
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000648938200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.jhep-reports.eu/article/S2589-5559(20)30078-1/fulltext
UR  - http://hdl.handle.net/10044/1/92685
VL  - 2
ER  -
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