Imperial College London
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ProfessorMaudLemoine

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor and Honorary Consultant in Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 5212m.lemoine

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Toye:2021:10.3390/microorganisms9030623,
author = {Toye, RM and Cohen, D and Pujol, FH and Sow-Sall, A and Lo, G and Hoshino, K and Mizokami, M and Zoulim, F and Lemoine, M and Toure-Kane, C and Chemin, I},
doi = {10.3390/microorganisms9030623},
journal = {Microorganisms},
title = {Hepatitis B Virus Genotype Study in West Africa Reveals an Expanding Clade of Subgenotype A4},
url = {http://dx.doi.org/10.3390/microorganisms9030623},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hepatitis B virus (HBV) classification comprises up to 10 genotypes with specific geographical distribution worldwide, further subdivided into 40 subgenotypes, which have different impacts on liver disease outcome. Though extensively studied, the classification of subgenotype A sequences remains ambiguous. This study aimed to characterize HBV isolates from West African patients and propose a more advanced classification of subgenotype A. Fourteen HBV full-length genome sequences isolated from patients from The Gambia and Senegal were obtained and phylogenetically analyzed. Phylogenetic analysis of HBV genotype A sequences isolated from Senegalese and Gambian patients exhibited separate clusters from the other known and confirmed subgenotypes A (A1, A2, A6). Most of the sequences (10/14) clustered with an isolate from Cuba, reported as subgenotype A4 (supported by maximal bootstrap value). Four isolates from The Gambia and Senegal clustered separately from all other subgenotypes and samples sequenced in the study. Three of which from The Gambia, designated as an expanding clade of subgenotype A4, exhibited a mean inter-subgenotypic nucleotide divergence over the entire genome sequence higher than 4% in comparison with the other subgenotypes and the other isolates sequenced in the study, except with subgenotype A4 isolates (3.9%), and this was supported by a maximal bootstrap value. The last one from Senegal seemed to be an expanding subgenotype close to the new clade of A4. Amino acid analysis unveiled a novel motif specific to these isolates. This study revealed an expanding evolution of HBV subgenotype A and novel amino acid motifs. It also highlighted the need for a consensus regarding the analysis and classification of HBV sequences
AU  - Toye,RM
AU  - Cohen,D
AU  - Pujol,FH
AU  - Sow-Sall,A
AU  - Lo,G
AU  - Hoshino,K
AU  - Mizokami,M
AU  - Zoulim,F
AU  - Lemoine,M
AU  - Toure-Kane,C
AU  - Chemin,I
DO  - 10.3390/microorganisms9030623
PY  - 2021///
SN  - 2076-2607
TI  - Hepatitis B Virus Genotype Study in West Africa Reveals an Expanding Clade of Subgenotype A4
T2  - Microorganisms
UR  - http://dx.doi.org/10.3390/microorganisms9030623
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000633894500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2076-2607/9/3/623
UR  - http://hdl.handle.net/10044/1/93198
VL  - 9
ER  -
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