Imperial College London
Portrait Picture

ProfessorMichaelLevin

Faculty of Medicine, Department of Infectious Disease

Chair in Paediatrics & International Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3760m.levin Website

 
 
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Location

 

233Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

378 results found

Pathan N, Sandiford C, Harding SE, Levin Met al., 2002, Characterization of a myocardial depressant factor in meningococcal septicemia, CRITICAL CARE MEDICINE, Vol: 30, Pages: 2191-2198, ISSN: 0090-3493

Journal article

Harrison OB, Robertson BD, Faust SN, Jepson MA, Goldin RD, Levin M, Heyderman RSet al., 2002, Analysis of pathogen-host cell interactions in purpura fulminans:: Expression of capsule, type IV pili, and PorA by <i>Neisseria meningitidis</i> in vivo, INFECTION AND IMMUNITY, Vol: 70, Pages: 5193-5201, ISSN: 0019-9567

Journal article

Wills BA, Oragui EE, Stephens AC, Daramola OA, Dung NM, Loan HT, Chau NV, Chambers M, Stepniewska K, Farrar JJ, Levin Met al., 2002, Coagulation abnormalities in dengue hemorrhagic fever: Serial investigations in 167 Vietnamese children with dengue shock syndrome, CLINICAL INFECTIOUS DISEASES, Vol: 35, Pages: 277-285, ISSN: 1058-4838

Journal article

Jacobs M, Levin M, 2002, An improved endothelial barrier model to investigate dengue haemorrhagic fever, JOURNAL OF VIROLOGICAL METHODS, Vol: 104, Pages: 173-185, ISSN: 0166-0934

Journal article

Brogan PA, Bose A, Burgner D, Shingadia D, Tulloh R, Michie C, Klein N, Booy R, Levin M, Dillon MJet al., 2002, Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 86, Pages: 286-290, ISSN: 0003-9888

Journal article

Faust SN, Heyderman RS, Levin M, 2001, Endothelial protein C activation in meningococcal sepsis. Reply, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 345, Pages: 1777-1777, ISSN: 0028-4793

Journal article

Morley SL, Cole MJ, Ison CA, Camaraza MA, Sotolongo F, Anwar N, Cuevas I, Carbonero M, Campa HC, Sierra G, Levin Met al., 2001, Immunogenicity of a serogroup B meningococcal vaccine against multiple <i>Neisseria meningitidis</i> strains in infants, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 20, Pages: 1054-1061, ISSN: 0891-3668

Journal article

Booy R, Habibi P, Nadel S, de Munter C, Britto J, Morrison A, Levin Met al., 2001, Reduction in case fatality rate from meningococcal disease associated with improved healthcare delivery, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 85, Pages: 386-390, ISSN: 0003-9888

Journal article

Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, Laszik Z, Esmon CT, Heyderman RSet al., 2001, Dysfunction of endothelial protein C activation in severe meningococcal sepsis., NEW ENGLAND JOURNAL OF MEDICINE, Vol: 345, Pages: 408-416, ISSN: 0028-4793

Journal article

Sandell JM, Ramnarayan P, Welch S, Levin M, Britto Jet al., 2001, Meningococcal disease due to strain W135, LANCET, Vol: 358, Pages: 76-76, ISSN: 0140-6736

Journal article

Faust SN, Heyderman RS, Levin M, 2001, Coagulation in severe sepsis: A central role for thrombomodulin and activated protein C, CRITICAL CARE MEDICINE, Vol: 29, Pages: S62-S67, ISSN: 0090-3493

Journal article

Giroir BP, Scannon PJ, Levin M, 2001, Bactericidal/permeability-increasing protein -: Lessons learned from the phase III, randomized, clinical trial of rBPI<sub>21</sub> for adjunctive treatment of children with severe meningococcemia, Margaux Conference on Critical Illness, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S130-S135, ISSN: 0090-3493

Conference paper

Eling M, Stephens AC, Oragui EE, Rivers RPA, Levin Met al., 2001, Tissue factor pathway inhibitor (TFPI) levels in the plasma and urine of children with meningococcal disease, THROMBOSIS AND HAEMOSTASIS, Vol: 85, Pages: 240-244, ISSN: 0340-6245

Journal article

Bolt P, Britto J, Nadel S, Levin Met al., 2001, Meningococcal disease due to W135: fresh public health concerns, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 84, Pages: 90-91, ISSN: 0003-9888

Journal article

Pathan N, Faust SN, Levin M, 2001, Bacterial meningitis and brain abscess, Medicine, Vol: 29, Pages: 49-54, ISSN: 1357-3039

Journal article

Hibberd M, Summerfield JA, Levin M, 2001, Variation in the mannose binding lectin (MBL) gene and susceptibility to sepsis, Sepsis, Pages: 201-207

Journal article

Pollard AJ, Levin M, 2000, Production of low-avidity antibody by infants after infection with serogroup B meningococci, LANCET, Vol: 356, Pages: 2065-2066, ISSN: 0140-6736

Journal article

Levin M, Newport M, 2000, Inherited predisposition to mycobacterial infection: historical considerations, MICROBES AND INFECTION, Vol: 2, Pages: 1549-1552, ISSN: 1286-4579

Journal article

Levin M, Quint PA, Goldstein B, Barton P, Bradley JS, Shemie SD, Yeh T, Kim SS, Cafaro DP, Scannon PJ, Giroir BPet al., 2000, Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group., Lancet, Vol: 356, Pages: 961-967, ISSN: 0140-6736

BACKGROUND: Endotoxin is a primary trigger of the inflammatory processes that lead to shock, multiorgan failure, and purpura fulminans in meningococcal sepsis. Bactericidal/permeability-increasing protein (BPI) is a natural protein, stored within the neutrophil granules, that binds to and neutralises the effects of endotoxin in vitro, in laboratory animals, and in humans. To establish whether a recombinant 21-kDa modified fragment of human BPI (rBPI21), containing the active antimicrobial and endotoxin-neutralising moiety, would decrease death and long-term disability from meningococcal sepsis, we did a randomised, double-blind, placebo-controlled trial of rBPI21 in children with severe meningococcal sepsis. METHODS: We enrolled children (2 weeks to 18 years of age) presenting to 22 centres in the UK and the USA with a clinical picture suggestive of meningococcal sepsis, and with evidence of severe disease. Children were randomly assigned rBPI21 (2 mg/kg over 30 min followed by 2 mg/kg over 24 h) or placebo (0.2 mg/mL human albumin solution) in addition to conventional medical therapy. Primary outcome variables were mortality, amputations, and change in paediatric overall performance category (POPC) from before illness to day 60. Analysis was by intention to treat. FINDINGS: Of 1287 patients screened, 892 were excluded, including 57 patients who died or who met criteria for imminent death before receiving the study drug. 190 patients received rBPI21, and 203 placebo. 34 (8.7%) of 393 patients died during the study: 14 (7.4%) in the rBPI21 group and 20 (9.9%) in the placebo group (odds ratio 1.31 [95% CI 0.62-2.74], p=0.48). Compared with patients randomised to placebo, fewer patients treated with rBPI21 had multiple severe amputations (six of 190 [3.2%] vs 15 of 203 [7.4%], odds ratio 2.47 [0.94-6.51], p=0.067), and more had a functional outcome similar to that before illness (as measured by the POPC scale) at day 60 (136 of 176 [77.3%] vs 126 of 190 [66.3%], p=0.01

Journal article

Levin M, Quint PA, Goldstein B, Barton P, Bradley JS, Shemie SD, Yeh T, Kim SS, Cafaro DP, Scannon PJ, Giroir BPet al., 2000, Recombinant bactericidal/permeability-increasing protein (rBPI<sub>21</sub>) as adjunctive treatment for children with severe meningococcal sepsis:: a randomised trial, LANCET, Vol: 356, Pages: 961-967, ISSN: 0140-6736

Journal article

Pathan N, Nadel S, Levin M, 2000, Pathophysiology and management of meningococcal septicaemia, JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, Vol: 34, Pages: 436-444, ISSN: 0035-8819

Journal article

Kampmann B, Gaora PO, Snewin VA, Gares MP, Young DB, Levin Met al., 2000, Evaluation of human antimycobacterial immunity using recombinant reporter mycobacteria, JOURNAL OF INFECTIOUS DISEASES, Vol: 182, Pages: 895-901, ISSN: 0022-1899

Journal article

Mehta N, Levin M, 2000, Management and prevention of meningococcal disease, HOSPITAL PRACTICE, Vol: 35, Pages: 75-+, ISSN: 8750-2836

Journal article

Thiru Y, Pathan N, Bignall S, Habibi P, Levin Met al., 2000, A myocardial cytotoxic process is involved in the cardiac dysfunction of meningococcal septic shock, CRITICAL CARE MEDICINE, Vol: 28, Pages: 2979-2983, ISSN: 0090-3493

Journal article

Oragui EE, Nadel S, Kyd P, Levin Met al., 2000, Increased excretion of urinary glycosaminoglycans in meningococcal septicemia and their relationship to proteinuria, CRITICAL CARE MEDICINE, Vol: 28, Pages: 3002-3008, ISSN: 0090-3493

Journal article

Faust SN, Heyderman RS, Levin M, 2000, Disseminated intravascular coagulation and purpura fulminans secondary to infection, BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, Vol: 13, Pages: 179-197, ISSN: 1521-6926

Journal article

Davies MS, Nadel S, Habibi P, Levin M, Hunt DMet al., 2000, The orthopaedic management of peripheral ischaemia in meningococcal septicaemia in children, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, Vol: 82B, Pages: 383-386, ISSN: 0301-620X

Journal article

Curtis N, Goodsall A, Levin M, 2000, Evidence that staphylococcal toxic shock syndrome and Kawasaki Disease share a common etiology, PEDIATRIC RESEARCH, Vol: 47, Pages: 562-562, ISSN: 0031-3998

Journal article

Pollard AJ, Levin M, 2000, Vaccines for prevention of meningococcal disease, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 19, Pages: 333-345, ISSN: 0891-3668

Journal article

Rangel L, Garralda ME, Levin M, Roberts Het al., 2000, The course of severe chronic fatigue syndrome in childhood, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 93, Pages: 129-134, ISSN: 0141-0768

Journal article

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