Imperial College London
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ProfessorMichaelLevin

Faculty of Medicine, Department of Infectious Disease

Chair in Paediatrics & International Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3760m.levin Website

 
 
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Location

 

233Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Menikou:2019:10.3389/fimmu.2019.01156,
author = {Menikou, S and Langford, P and Levin, M},
doi = {10.3389/fimmu.2019.01156},
journal = {Frontiers in Immunology},
title = {Kawasaki disease: the role of immune complexes revisited},
url = {http://dx.doi.org/10.3389/fimmu.2019.01156},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Kawasaki disease (KD) is an inflammatory disease in children associated with vasculitis affecting predominantly the coronary arteries and is now the most common cause of acquired heart disease in children in developed countries. The etiology of KD is unknown but epidemiological studies implicate an infectious agent or toxin, which causes disease in genetically predisposed individuals. The presence of immune complexes (ICs) in the serum of children with KD was established in numerous studies during the 1970s and 80s. More recent genetic studies have identified variation in Fcγ receptors and genes controlling immunoglobulin production associated with KD. In this review we link the genetic findings and IC studies and suggest a key role for their interaction in pathophysiology of the disease.
AU  - Menikou,S
AU  - Langford,P
AU  - Levin,M
DO  - 10.3389/fimmu.2019.01156
PY  - 2019///
SN  - 1664-3224
TI  - Kawasaki disease: the role of immune complexes revisited
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2019.01156
UR  - http://hdl.handle.net/10044/1/70480
VL  - 10
ER  -
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