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@article{Hodeib:2020:10.1007/s00439-020-02128-4,
author = {Hodeib, S and Herberg, JA and Levin, M and Sancho-Shimizu, V},
doi = {10.1007/s00439-020-02128-4},
journal = {Human Genetics},
pages = {961--980},
title = {Human genetics of meningococcal infections},
url = {http://dx.doi.org/10.1007/s00439-020-02128-4},
volume = {139},
year = {2020}
}

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TY  - JOUR
AB  - Neisseria meningitidis is a leading cause of bacterial septicaemia and meningitis worldwide. Meningococcal disease is rare but can be life threatening with a tendency to affect children. Many studies have investigated the role of human genetics in predisposition to N. meningitidis infection. These have identified both rare single-gene mutations as well as more common polymorphisms associated with meningococcal disease susceptibility and severity. These findings provide clues to the pathogenesis of N. meningitidis, the basis of host susceptibility to infection and to the aetiology of severe disease. From the multiple discoveries of monogenic complement deficiencies to the associations of complement factor H and complement factor H-related three polymorphisms to meningococcal disease, the complement pathway is highlighted as being central to the genetic control of meningococcal disease. This review aims to summarise the current understanding of the host genetic basis of meningococcal disease with respect to the different stages of meningococcal infection.
AU  - Hodeib,S
AU  - Herberg,JA
AU  - Levin,M
AU  - Sancho-Shimizu,V
DO  - 10.1007/s00439-020-02128-4
EP  - 980
PY  - 2020///
SN  - 0340-6717
SP  - 961
TI  - Human genetics of meningococcal infections
T2  - Human Genetics
UR  - http://dx.doi.org/10.1007/s00439-020-02128-4
UR  - https://link.springer.com/article/10.1007%2Fs00439-020-02128-4
UR  - http://hdl.handle.net/10044/1/76890
VL  - 139
ER  -

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